A high linoleic acid diet exacerbates metabolic responses and gut microbiota dysbiosis in obese rats with diabetes mellitus

2019 ◽  
Vol 10 (2) ◽  
pp. 786-798 ◽  
Author(s):  
Hsiu-Chuan Lee ◽  
Shao-Chuan Yu ◽  
Yun-Chun Lo ◽  
I-Hsuan Lin ◽  
Te-Hsuan Tung ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Linoleic Acid ◽  
Inflammatory Responses ◽  
Metabolic Responses ◽  
High Linoleic Acid ◽  
Dietary Polyunsaturated Fatty Acid ◽  
Acid Diet ◽  
Obese Rats ◽  
Linoleic Acid Diet ◽  
Gut Microbiota Dysbiosis

Dietary polyunsaturated fatty acid (PUFA) levels may affect inflammatory responses and lipid metabolism.

Effect of a High Linoleic Acid Diet and Thiazide on Sodium Chloride-Induced Hypertension in Rats

1982 ◽  
Vol 63 (s8) ◽  
pp. 239s-241s ◽  
Author(s):  
Louis Tobian ◽  
Mary Ann Johnson ◽  
Mukul Ganguli ◽  
Judith Lange ◽  
Karen Kartheiser ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Linoleic Acid ◽  
Reduce Blood Pressure ◽  
Water Excretion ◽  
High Linoleic Acid ◽  
Acid Diet ◽  
Pge2 Concentration ◽  
Induced Hypertension ◽  
Arterial Inflow ◽  
Linoleic Acid Diet

1. Hypertension-prone Dahl S rats on either low or high NaCl diets have less than half the concentration of prostaglandin E2 (PGE2) in quick-frozen renal papillae compared with that of hypertension-resistant Dahl R rats. 2. A 4% high NaCl diet doubles the concentration of PGE2 in the renal papillae compared with the effect of a moderately low (0.3%) NaCl diet. 3. A diet with 16% linoleic acid triples the PGE2 concentration in S papillae and increases it 2.5 times in R papillae, compared with a diet with 1.5% linoleic acid. 4. The 16% linoleic acid diet also delays the onset of NaCl-induced hypertension and prevents about half of the ultimate rise in blood pressure. 5. The low PGE2 concentration in the renal papillae of S rats could contribute to a tendency toward sodium retention and thereby encourage NaCl-induced hypertension. 6. Thiazides greatly increase sodium and water excretion in isolated kidneys from pre-hypertensive S rats perfused with blood at a normotensive arterial inflow pressure. This effect would allow brisk natriuresis without the need for hypertensive arterial pressures and could thereby reduce blood pressure in NaCl-related hypertension.

A high linoleic acid diet diminishes enhanced intestinal uptake of sugars in diabetic rats

1987 ◽  
Vol 252 (2) ◽  
pp. G262-G271 ◽  
Author(s):  
A. B. Thomson ◽  
M. Keelan ◽  
M. T. Clandinin ◽  
K. Walker
Keyword(s):  
Fatty Acids ◽  
Linoleic Acid ◽  
Surface Area ◽  
Diabetic Rats ◽  
Intestinal Uptake ◽  
High Linoleic Acid ◽  
Acid Diet ◽  
Villous Surface ◽  
Linoleic Acid Diet ◽  
Mucosal Surface Area

Intestinal absorption is altered in rats by diabetes and by dietary manipulation. For 5 wk rats were fed chow (C) or semisynthetic diets containing isocaloric amounts of a high content of either polyunsaturated (P) or saturated (S) fatty acids; then half were rendered hyperglycemic with streptozotocin while the remaining half served as nondiabetic controls. Studies were performed after a total of 8 wk on C, P, or S. Jejunal villous surface area was greater in diabetic rats than in control rats fed C or S, whereas the jejunal mucosal surface area was significantly greater in diabetic animals than in control animals only when they were fed S. Ileal mucosal surface area was similar in diabetic and in control rats fed C, S, or P; although ileal villous surface area was greater in diabetic than in control rats only when they were fed C. The jejunal and ileal uptake of varying concentrations of glucose and galactose was higher in diabetic rats than controls fed C or S. In contrast, the enhanced uptake of these sugars was reduced or normalized in diabetic rats fed P. The jejunal brush-border membrane (BBM) content of phospholipids was higher in diabetic than in control rats fed chow, but there was no difference in diabetic vs. control animals fed P or S in BBM total free fatty acids, phospholipids, or cholesterol. Thus feeding a high linoleic acid diet diminishes the enhanced intestinal uptake of glucose and galactose in diabetic rats.(ABSTRACT TRUNCATED AT 250 WORDS)

A High Linoleic Acid Diet does not Induce Inflammation in Mouse Liver or Adipose Tissue

Lipids ◽  
2015 ◽  
Vol 50 (11) ◽  
pp. 1115-1122 ◽  
Author(s):  
Roger A. Vaughan ◽  
Richard L. Garrison ◽  
Alexis D. Stamatikos ◽  
Minsung Kang ◽  
Jamie A. Cooper ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Linoleic Acid ◽  
Mouse Liver ◽  
High Linoleic Acid ◽  
Acid Diet ◽  
Linoleic Acid Diet

scholarly journals Effect of High Linoleic Acid Diet on Carbohydrate‐stimulated Expression of Lipogenic Genes

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
Kathleen Axen ◽  
Marianna Harper ◽  
Tushara Edupghanti ◽  
JoAnn Brown ◽  
Kadeem Thomas ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
High Linoleic Acid ◽  
Lipogenic Genes ◽  
Acid Diet ◽  
Linoleic Acid Diet
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