Mushroom small RNAs as potential anticancer agents: a closer look at Cantharellus cibarius proapoptotic and antiproliferative effects in colon cancer cells

2019 ◽  
Vol 10 (5) ◽  
pp. 2739-2751 ◽  
Author(s):  
Marta K. Lemieszek ◽  
Patrícia S. Marques ◽  
Miguel Ribeiro ◽  
Daniela Ferreira ◽  
Guilhermina Marques ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Small Rnas ◽  
Colon Cancer Cells ◽  
Antiproliferative Effects ◽  
Anticancer Properties

Screening aimed at the evaluation of the presence of small RNAs with anticancer properties in Boletus spretus, B. pinophilus and Cantharellus cibarius, was conducted.

scholarly journals Autumn Royal and Ribier Grape Juice Extracts Reduced Viability and Metastatic Potential of Colon Cancer Cells

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Manuel Valenzuela ◽  
Lorena Bastias ◽  
Iván Montenegro ◽  
Enrique Werner ◽  
Alejandro Madrid ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Grape Juice ◽  
Metastatic Potential ◽  
Migration And Invasion ◽  
Dependent Manner ◽  
Colon Cancer Cells ◽  
Gene Expressions ◽  
Anticancer Properties

Antioxidants are known to be beneficial to health. This paper evaluates the potential chemopreventive and anticancer properties of phenolic compounds present in grape juice extracts (GJE) from Autumn Royal and Ribier varieties. The effects of these GJE on viability (SRB day assay) and metastatic potential (migration and invasion parameters) of colon cancer cell lines HT-29 and SW-480 were evaluated. The effects of GJE on two matrix metalloproteinase gene expressions (MMP2 and MMP9) were also evaluated via qRT-PCR. In the former, GJE reduced cell viability in both cell lines in a dose-dependent manner. GJE treatment also reduced cell migration and invasion. Moreover, MMP-2 and MMP-9 gene expression diminished depending on extract and on cell type.Conclusions. These results provide novel information concerning anticancer properties of selected GJE by revealing selective cytotoxicity and the ability to reduce invasiveness of colon cancer cells.

Antiproliferative effects of selenium compounds in colon cancer cells: Comparison of different cytotoxicity assays

2009 ◽  
Vol 23 (7) ◽  
pp. 1406-1411 ◽  
Author(s):  
Ladislava Schröterová ◽  
Věra Králová ◽  
Adéla Voráčová ◽  
Pavlína Hašková ◽  
Emil Rudolf ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Selenium Compounds ◽  
Antiproliferative Effects ◽  
Cytotoxicity Assays

scholarly journals Albumin Nano-Encapsulation of Piceatannol Enhances Its Anticancer Potential in Colon Cancer Via Downregulation of Nuclear p65 and HIF-1α

Cancers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 113 ◽  
Author(s):  
Alaa A. A. Aljabali ◽  
Hamid A. Bakshi ◽  
Faruck L. Hakkim ◽  
Yusuf A. Haggag ◽  
Khalid M. Al-Batanyeh ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Anticancer Agents ◽  
Therapeutic Potential ◽  
Hypoxia Inducible Factor ◽  
In Vitro Cytotoxicity ◽  
Colon Cancer Cells ◽  
Chemical Colitis ◽  
Clinical Trails

Piceatannol (PIC) is known to have anticancer activity, which has been attributed to its ability to block the proliferation of cancer cells via suppression of the NF-kB signaling pathway. However, its effect on hypoxia-inducible factor (HIF) is not well known in cancer. In this study, PIC was loaded into bovine serum albumin (BSA) by desolvation method as PIC–BSA nanoparticles (NPs). These PIC–BSA nanoparticles were assessed for in vitro cytotoxicity, migration, invasion, and colony formation studies and levels of p65 and HIF-1α. Our results indicate that PIC–BSA NPs were more effective in downregulating the expression of nuclear p65 and HIF-1α in colon cancer cells as compared to free PIC. We also observed a significant reduction in inflammation induced by chemical colitis in mice by PIC–BSA NPs. Furthermore, a significant reduction in tumor size and number of colon tumors was also observed in the murine model of colitis-associated colorectal cancer, when treated with PIC–BSA NPs as compared to free PIC. The overall results indicate that PIC, when formulated as PIC–BSA NPs, enhances its therapeutic potential. Our work could prompt further research in using natural anticancer agents as nanoparticels with possible human clinical trails. This could lead to the development of a new line of safe and effective therapeutics for cancer patients.

Berry Extracts Exert Different Antiproliferative Effects against Cervical and Colon Cancer Cells Grown in Vitro

2008 ◽  
Vol 56 (9) ◽  
pp. 3016-3023 ◽  
Author(s):  
Gordon J. McDougall ◽  
Heather A. Ross ◽  
Magnus Ikeji ◽  
Derek Stewart
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Antiproliferative Effects ◽  
Berry Extracts

scholarly journals Antiproliferative Effects of Fluoxetine on Colon Cancer Cells and in a Colonic Carcinogen Mouse Model

PLoS ONE ◽  
2012 ◽  
Vol 7 (11) ◽  
pp. e50043 ◽  
Author(s):  
Vinicius Kannen ◽  
Henning Hintzsche ◽  
Dalila L. Zanette ◽  
Wilson A. Silva ◽  
Sérgio B. Garcia ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Mouse Model ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Antiproliferative Effects

Terpene Conjugates of Diaminedichloridoplatinum(II) Complexes: Antiproliferative Effects in HL-60 Leukemia, 518A2 Melanoma, and HT-29 Colon Cancer Cells

2008 ◽  
Vol 5 (8) ◽  
pp. 1645-1659 ◽  
Author(s):  
Günther Bernhardt ◽  
Bernhard Biersack ◽  
Susanne Bollwein ◽  
Rainer Schobert ◽  
Miroslava Zoldakova
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Colon Cancer Cells ◽  
Antiproliferative Effects ◽  
Ht 29
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