scholarly journals A high-fat high-sugar diet in adolescent rats impairs social memory and alters chemical markers characteristic of atypical neuroplasticity and parvalbumin interneuron depletion in the medial prefrontal cortex

2019 ◽  
Vol 10 (4) ◽  
pp. 1985-1998 ◽  
Author(s):  
Amy C. Reichelt ◽  
Gabrielle D. Gibson ◽  
Kirsten N. Abbott ◽  
Dominic J. Hare
Keyword(s):  
Prefrontal Cortex ◽  
Social Development ◽  
Medial Prefrontal Cortex ◽  
Social Memory ◽  
Memory Deficits ◽  
Chemical Markers ◽  
High Fat ◽  
Parvalbumin Interneuron ◽  
Adolescent Rats ◽  
Hypercaloric Diet

A hypercaloric diet given to adolescent rats induces social memory deficits and reduced neurochemical markers of normal social development.

scholarly journals Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

2018 ◽  
Author(s):  
Mary L. Phillips ◽  
Holly A. Robinson ◽  
Lucas Pozzo-Miller
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Social Memory ◽  
Memory Deficits ◽  
Autism Spectrum ◽  
Innervation Pattern ◽  
Wild Type ◽  
Contributing Factors ◽  
Social Memories

SUMMARYInputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) have been implicated in several neuropsychiatric disorders. Here, we show that the long-range vHIP-mPFC projection is hyperactive in the Mecp2 knockout (KO) mouse model of the autism spectrum disorder Rett syndrome, which has deficits in social memory. Chronically mimicking vHIP-mPFC hyperexcitability in wild-type mice impaired social memory, whereas chronic inhibition of mPFC-projecting vHIP neurons in Mecp2 KO mice rescued social memory deficits; the extent of memory rescue was negatively correlated with the strength of vHIP input to the mPFC. Acute manipulations of the vHIP-mPFC projection also affected social memory in a specific and selective manner, suggesting that proper vHIP-mPFC signaling is necessary to recall social memories. In addition, we identified an altered vHIP-mPFC innervation pattern and increased synaptic strength onto layer 5 pyramidal neurons as contributing factors in aberrant vHIP-mPFC signaling in Mecp2 KO mice.

Decreased synaptic plasticity in the medial prefrontal cortex underlies short-term memory deficits in 6-OHDA-lesioned rats

2016 ◽  
Vol 301 ◽  
pp. 43-54 ◽  
Author(s):  
Filipe C. Matheus ◽  
Daniel Rial ◽  
Joana I. Real ◽  
Cristina Lemos ◽  
Juliana Ben ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Plasticity ◽  
Medial Prefrontal Cortex ◽  
Short Term Memory ◽  
Memory Deficits ◽  
Short Term ◽  
Term Memory

scholarly journals Ventral hippocampal projections to the medial prefrontal cortex regulate social memory

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Mary L Phillips ◽  
Holly Anne Robinson ◽  
Lucas Pozzo-Miller
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Pyramidal Neurons ◽  
Social Memory ◽  
Autism Spectrum ◽  
Contributing Factors ◽  
Knockout Mouse Model ◽  
And Behavior ◽  
Social Memories

Inputs from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC) are implicated in several neuropsychiatric disorders. Here, we show that the vHIP-mPFC projection is hyperactive in the Mecp2 knockout mouse model of the autism spectrum disorder Rett syndrome, which has deficits in social memory. Long-term excitation of mPFC-projecting vHIP neurons in wild-type mice impaired social memory, whereas their long-term inhibition in Rett mice rescued social memory deficits. The extent of social memory improvement was negatively correlated with vHIP-evoked responses in mPFC slices, on a mouse-per-mouse basis. Acute manipulations of the vHIP-mPFC projection affected social memory in a region and behavior selective manner, suggesting that proper vHIP-mPFC signaling is necessary to recall social memories. In addition, we identified an altered pattern of vHIP innervation of mPFC neurons, and increased synaptic strength of vHIP inputs onto layer five pyramidal neurons as contributing factors of aberrant vHIP-mPFC signaling in Rett mice.

scholarly journals Parvalbumin interneuron in the ventral hippocampus functions as a discriminator in social memory

2019 ◽  
Vol 116 (33) ◽  
pp. 16583-16592 ◽  
Author(s):  
Xiaofei Deng ◽  
Lijia Gu ◽  
Nan Sui ◽  
Jianyou Guo ◽  
Jing Liang
Keyword(s):  
Social Memory ◽  
Imaging Technique ◽  
Memory Deficits ◽  
Social Recognition ◽  
Optogenetic Stimulation ◽  
Mental Diseases ◽  
Parvalbumin Interneurons ◽  
Parvalbumin Interneuron

The ability to identify strange conspecifics in societies is supported by social memory, which is vital for gregarious animals and humans. The function of hippocampal principal neurons in social memory has been extensively investigated; however, the nonprincipal neuronal mechanism underlying social memory remains unclear. Here, we first observed parallel changes in the ability for social recognition and the number of parvalbumin interneurons (PVIs) in the ventral CA1 (vCA1) after social isolation. Then, using tetanus toxin-mediated neuronal lesion and optogenetic stimulation approaches, we revealed that vCA1-PVIs specifically engaged in the retrieval stage of social memory. Finally, through the in vivo Ca2+ imaging technique, we demonstrated that vCA1-PVIs exhibited higher activities when subjected mice approached a novel mouse than to a familiar one. These results highlight the crucial role of vCA1-PVIs for distinguishing novel conspecifics from other individuals and contribute to our understanding of the neuropathology of mental diseases with social memory deficits.

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