Resveratrol improves intestinal barrier function, alleviates mitochondrial dysfunction and induces mitophagy in diquat challenged piglets1

2019 ◽  
Vol 10 (1) ◽  
pp. 344-354 ◽  
Author(s):  
Shuting Cao ◽  
Zhuojun Shen ◽  
Chunchun Wang ◽  
Qianhui Zhang ◽  
Qihua Hong ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Mitochondrial Function ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Injury ◽  
Intestinal Barrier Function

This study evaluated whether resveratrol can alleviate intestinal injury and enhance the mitochondrial function and the mitophagy level in diquat induced oxidative stress of piglets.

scholarly journals L-Tryptophan Enhances Intestinal Integrity in Diquat-Challenged Piglets Associated with Improvement of Redox Status and Mitochondrial Function

Animals ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. 266 ◽  
Author(s):  
Jingbo Liu ◽  
Yong Zhang ◽  
Yan Li ◽  
Honglin Yan ◽  
Hongfu Zhang
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Dysfunction ◽  
Growth Performance ◽  
Mitochondrial Function ◽  
Intestinal Barrier ◽  
Dietary Supplementation ◽  
Fluorescein Isothiocyanate ◽  
Redox Status ◽  
Intestinal Barrier Function ◽  
Intestinal Integrity

Tryptophan (Trp) supplementation has been shown to improve growth performance and enhance intestinal integrity in piglets. However, the effects of dietary Trp supplementation on the intestinal barrier function in piglets exposed to oxidative stress remain unknown. This study was conducted to evaluate whether dietary Trp supplementation can attenuate intestinal injury, oxidative stress, and mitochondrial dysfunction of piglets caused by diquat injection. Thirty-two piglets at 25 days of age were randomly allocated to four groups: (1) the non-challenged control; (2) diquat-challenged control; (3) 0.15% Trp-supplemented diet + diquat; (4) 0.30% Trp supplemented diet + diquat. On day seven, the piglets were injected intraperitoneally with sterilized saline or diquat (10 mg/kg body weight). The experiment lasted 21 days. Dietary supplementation with 0.15% Trp improved growth performance of diquat-challenged piglets from day 7 to 21. Diquat induced an increased intestinal permeability, impaired antioxidant capacity, and mitochondrial dysfunction. Although dietary supplementation with 0.15% Trp ameliorated these negative effects induced by diquat challenge that showed decreasing permeability of 4 kDa fluorescein isothiocyanate dextran, increasing antioxidant indexes, and enhancing mitochondrial biogenesis. Results indicated that dietary supplementation with 0.15% Trp enhanced intestinal integrity, restored the redox status, and improved the mitochondrial function of piglets challenged with diquat.

Heat-killed body of lactobacillus brevis SBC8803 ameliorates intestinal injury in a murine model of colitis by enhancing the intestinal barrier function

2011 ◽  
Vol 17 (11) ◽  
pp. 2235-2250 ◽  
Author(s):  
Nobuhiro Ueno ◽  
Mikihiro Fujiya ◽  
Shuichi Segawa ◽  
Toshie Nata ◽  
Kentaro Moriichi ◽  
...  
Keyword(s):  
Murine Model ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Lactobacillus Brevis ◽  
Intestinal Injury ◽  
Intestinal Barrier Function

Exposure to oxidized soybean oil induces mammary mitochondrial injury in lactating rats and alters the intestinal barrier function of progeny

2021 ◽  
Vol 12 (8) ◽  
pp. 3705-3719
Author(s):  
Chuanqi Wang ◽  
Feng Gao ◽  
Xin Guan ◽  
Xinxin Yao ◽  
Baoming Shi ◽  
...  
Keyword(s):  
Soybean Oil ◽  
Mitochondrial Function ◽  
Barrier Function ◽  
Intestinal Barrier ◽  
Intestinal Barrier Function ◽  
Mitochondrial Injury

The ingestion of OSO promoted the expression of mitochondrial function-related genes, such as Sirt3 and PRDX3, and these genes contributed to the elimination of oxidative production in mitochondria.

scholarly journals Preventive Effects of Bacillus licheniformis on Heat Stroke in Rats by Sustaining Intestinal Barrier Function and Modulating Gut Microbiota

2021 ◽  
Vol 12 ◽  
Author(s):  
Lei Li ◽  
Man Wang ◽  
Jikuai Chen ◽  
Zhuoran Xu ◽  
Shaokang Wang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Inflammatory Cytokines ◽  
Bacillus Licheniformis ◽  
Barrier Function ◽  
Heat Stroke ◽  
Intestinal Barrier ◽  
Intestinal Injury ◽  
Organ Injury ◽  
Intestinal Barrier Function ◽  
Preventive Effects

Heat stroke (HS) models in rats are associated with severe intestinal injury, which is often considered as the key event at the onset of HS. Probiotics can regulate the gut microbiota by inhibiting the colonization of harmful bacteria and promoting the proliferation of beneficial bacteria. Here, we investigated the preventive effects of a probiotic Bacillus licheniformis strain (BL, CMCC 63516) on HS rats as well as its effects on intestinal barrier function and gut microbiota. All rats were randomly divided into four groups: control (Con) + PBS (pre-administration with 1 ml PBS twice a day for 7 days, without HS induction), Con + BL group (pre-administration with 1 ml 1 × 108 CFU/ml BL twice a day for 7 days, without HS induction), HS + PBS (PBS, with HS induction), and HS + BL (BL, with HS induction). Before the study, the BL strain was identified by genomic DNA analysis. Experimental HS was induced by placing rats in a hot and humid chamber for 60 min until meeting the diagnostic criterion of HS onset. Body weight, core body temperature, survival rate, biochemical markers, inflammatory cytokines, and histopathology were investigated to evaluate the preventive effects of BL on HS. D-Lactate, I-FABP, endotoxin, and tight-junction proteins were investigated, and the fluorescein isothiocyanate-dextran (FD-4) test administered, to assess the degree of intestinal injury and integrity. Gut microbiota of rats in each group were analyzed by 16S rRNA sequencing. The results showed that pre-administration with BL significantly attenuated hyperthermia, reduced HS-induced death, alleviated multiple-organ injury, and decreased the levels of serum inflammatory cytokines. Furthermore, BL sustained the intestinal barrier integrity of HS rats by alleviating intestinal injury and improving tight junctions. We also found that BL significantly increased the ratios of two probiotic bacteria, Lactobacillus and Lactococcus. In addition, Romboutsia, a candidate biomarker for HS diagnosis, was unexpectedly detected. In summary, BL pre-administration for 7 days has preventative effects on HS that may be mediated by sustaining intestinal barrier function and modulating gut microbiota.

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