Uncovering the anti-proliferation mechanism and bioactive compounds in red kidney bean coat against B16-F10 melanoma cells by metabolomics and network pharmacology analysis

2019 ◽  
Vol 10 (2) ◽  
pp. 912-924 ◽  
Author(s):  
Jia-Hui Nie ◽  
Jian-Xiang Huang ◽  
Qing-Rong Wu ◽  
Xue-Mei Qin ◽  
Zhen-Yu Li
Keyword(s):  
Bioactive Compounds ◽  
Melanoma Cells ◽  
Kidney Bean ◽  
Network Pharmacology ◽  
Chemical Compositions ◽  
Anti Cancer ◽  
Red Kidney Bean ◽  
Cancer Activity

In this study, coat (RKBC) and kernel (RKBK) extracts of red kidney bean were prepared, and their chemical compositions and potential anti-cancer activity against B16-F10 cells were evaluated.

ANTICANCER EFFECT OF UVARIA GENUS

2014 ◽  
pp. 98-101
Author(s):  
Thi Bich Hien Le ◽  
Viet Duc Ho ◽  
Thi Hoai Nguyen
Keyword(s):  
Biological Activities ◽  
Current Trend ◽  
Healthcare Systems ◽  
Chemical Compositions ◽  
Cancer Therapies ◽  
Pharmacological Effects ◽  
Anticancer Effect ◽  
Anti Cancer ◽  
Tropical Areas ◽  
Cancer Activity

Nowadays, cancer treatment has been a big challenge to healthcare systems. Most of clinical anti-cancer therapies are toxic and cause adverse effects to human body. Therefore, current trend in science is seeking and screening of natural compounds which possess antineoplastic activities to utilize in treatment. Uvaria L. - Annonaceae includes approximately 175 species spreading over tropical areas of Asia, Australia, Africa and America. Studies on chemical compositions and pharmacological effects of Uvaria showed that several compound classes in this genus such as alkaloid, flavonoid, cyclohexen derivaties, acetogenin, steroid, terpenoid, etc. indicate considerable biological activities, for example anti-tumor, anti-cancer, antibacterial, antifungal, antioxidant, etc. Specifically, anti-cancer activity of fractions of extract and pure isolated compounds stands out for cytotoxicity against many cancer cell lines. This study provides an overview of anti-cancer activity of Uvaria and suggests a potential for further studies on seeking and developing novel anti-cancer compounds. Key words: Anti-cancer, Uvaria.

scholarly journals Novel carriers ensuring enhanced anti-cancer activity of Cornus mas (cornelian cherry) bioactive compounds

2020 ◽  
Vol 125 ◽  
pp. 109906 ◽  
Author(s):  
Zarrin Radbeh ◽  
Narmela Asefi ◽  
Hamed Hamishehkar ◽  
Leila Roufegarinejad ◽  
Akram Pezeshki
Keyword(s):  
Bioactive Compounds ◽  
Cornelian Cherry ◽  
Cornus Mas ◽  
Anti Cancer ◽  
Cancer Activity

scholarly journals Anti-Cancer Activity of Porphyran and Carrageenan from Red Seaweeds

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4286 ◽  
Author(s):  
Zhiwei Liu ◽  
Tianheng Gao ◽  
Ying Yang ◽  
Fanxin Meng ◽  
Fengping Zhan ◽  
...  
Keyword(s):  
Bioactive Compounds ◽  
Marine Environment ◽  
Animal Health ◽  
Natural Compounds ◽  
Chemotherapeutic Agents ◽  
Chemopreventive Agents ◽  
Red Seaweeds ◽  
Anti Cancer ◽  
Cancer Activity

Seaweeds are some of the largest producers of biomass in the marine environment and are rich in bioactive compounds that are often used for human and animal health. Porphyran and carrageenan are natural compounds derived from red seaweeds. The former is a characteristic polysaccharide of Porphyra, while the latter is well known from Chondrus, Gigartina, and various Eucheuma species, all in Rhodophyceae. The two polysaccharides have been found to have anti-cancer activity by improving immunity and targeting key apoptotic molecules and therefore deemed as potential chemotherapeutic or chemopreventive agents. This review attempts to review the current study of anti-cancer activity and the possible mechanisms of porphyran and carrageenan derived from red seaweeds to various cancers, and their cooperative actions with other anti-cancer chemotherapeutic agents is also discussed.

scholarly journals Evaluating the Anti-cancer Efficacy of a Synthetic Curcumin Analog on Human Melanoma Cells and Its Interaction with Standard Chemotherapeutics

Molecules ◽  
2019 ◽  
Vol 24 (13) ◽  
pp. 2483 ◽  
Author(s):  
Krishan Parashar ◽  
Siddhartha Sood ◽  
Ali Mehaidli ◽  
Colin Curran ◽  
Caleb Vegh ◽  
...  
Keyword(s):  
Curcuma Longa ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Curcumin Analog ◽  
Compound A ◽  
Human Melanoma Cells ◽  
Significant Toxicity ◽  
Anti Cancer ◽  
Induced Apoptosis ◽  
Cancer Activity

Melanoma is the leading cause of skin-cancer related deaths in North America. Metastatic melanoma is difficult to treat and chemotherapies have limited success. Furthermore, chemotherapies lead to toxic side effects due to nonselective targeting of normal cells. Curcumin is a natural product of Curcuma longa (turmeric) and has been shown to possess anti-cancer activity. However, due to its poor bioavailability and stability, natural curcumin is not an effective cancer treatment. We tested synthetic analogs of curcumin that are more stable. One of these derivatives, Compound A, has shown significant anti-cancer efficacy in colon, leukemia, and triple-negative inflammatory breast cancer cells. However, the effects of Compound A against melanoma cells have not been studied before. In this study, for the first time, we demonstrated the efficacy of Compound A for the selective induction of apoptosis in melanoma cells and its interaction with tamoxifen, taxol, and cisplatin. We found that Compound A induced apoptosis selectively in human melanoma cells by increasing oxidative stress. The anti-cancer activity of Compound A was enhanced when combined with tamoxifen and the combination treatment did not result in significant toxicity to noncancerous cells. Additionally, Compound A did not interact negatively with the anti-cancer activity of taxol and cisplatin. These results indicate that Compound A could be developed as a selective and effective melanoma treatment either alone or in combination with other non-toxic agents like tamoxifen.

Network pharmacology uncovers anti-cancer activity of vibsane-type diterpenes from Viburnum odoratissimum

2019 ◽  
pp. 1-4 ◽  
Author(s):  
Ying-Ying Zhang ◽  
Jing-Jie Chen ◽  
Dan-Qi Li ◽  
Yan- Zhang ◽  
Xiao-Bo Wang ◽  
...  
Keyword(s):  
Network Pharmacology ◽  
Anti Cancer ◽  
Viburnum Odoratissimum ◽  
Cancer Activity

scholarly journals Research on the mechanisms of taraxerol for the treatment of gastric cancer effect based on network pharmacology

2022 ◽  
Vol 36 ◽  
pp. 205873842110639
Author(s):  
Bingjie Huo ◽  
Yanru Song ◽  
Bibo Tan ◽  
Jianbo Li ◽  
Jie Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Molecular Mechanism ◽  
Migration And Invasion ◽  
Network Pharmacology ◽  
Pentacyclic Triterpene ◽  
Pharmacological Analysis ◽  
Anti Cancer ◽  
Cancer Activity

Background: Modern pharmacological studies have shown that traditional Chinese medicine (TCM) Taraxacum mongolicum possesses anti-cancer activity. Taraxerol (TRX) is a pentacyclic triterpene isolated from T. mongolicum, which is widely used in clinical treatment, and its anti-cancer effects have been extensively studied. However, the effects and molecular mechanism of TRX in gastric cancer (GC) have not been fully explicated. Methods: We used public databases to derive information on potential targets of TRX and proteins related to GC. Also, STRING and R3.6.2 software were used to analyze the protein–protein interaction (PPI). The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were done to explain the potential mechanism underlying the regulatory role of TRX in GC. The role of TRX in GC was verified by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide (MTT) assay, apoptosis analysis, Transwell assay, and wound healing assay, and the key signaling pathways were verified. Results: We identified 135 potential targets for the treatment of GC via network pharmacological analysis. GO and KEGG enrichment analysis showed that steroid hormone receptor activity and the PI3K/AKT signaling pathway were the biological processes and pathways with the highest degree of enrichment. Additionally, cellular experiments revealed that TRX inhibited the proliferation, migration, and invasion of GC cells as well as induced G1 phase arrest and apoptosis in GC cells. Conclusion: Here, we used multi-target and multi-pathway network pharmacological analysis to verify the anti-cancer activity of TRX in GC. Also, in vitro experimental data were used to derive the potential molecular mechanism.

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