The protective role of phloretin against dextran sulfate sodium-induced ulcerative colitis in mice

2019 ◽  
Vol 10 (1) ◽  
pp. 422-431 ◽  
Author(s):  
Zecai Zhang ◽  
Shan Li ◽  
Hongyang Cao ◽  
Peng Shen ◽  
Jiuxi Liu ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Oral Administration ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Protective Role

Oral administration of phloretin, mainly found in apples and strawberries, ameliorates ulcerative colitis in mice.

Oat β-glucan ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice

2015 ◽  
Vol 6 (11) ◽  
pp. 3454-3463 ◽  
Author(s):  
Bo Liu ◽  
Qinlu Lin ◽  
Tao Yang ◽  
Linna Zeng ◽  
Limin Shi ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Oral Administration ◽  
Inflammatory Cytokines ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Tnf Α

Oral administration of oat β-glucan ameliorates DSS induced colitis in mice by decreasing the expression of inflammatory cytokines TNF-α, IL-1β, IL-6 and iNOS.

Circular RNA HECTD1 Mitigates Ulcerative Colitis by Promoting Enterocyte Autophagy Via miR-182-5p/HuR Axis

2021 ◽  
Author(s):  
Yan Xu ◽  
Yuxi Tian ◽  
Fujun Li ◽  
Ying Wang ◽  
Junwen Yang ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Regulatory Mechanism ◽  
Therapeutic Potential ◽  
Circular Rna ◽  
Unknown Etiology ◽  
Mucosal Tissues ◽  
Related Proteins

Abstract Objective Ulcerative colitis (UC) is a chronic colitis with unknown etiology. Circular RNA (circRNA) has shown regulatory effect in many diseases, but the role of circRNA in UC is barely known. This study uncovers the function and regulatory mechanism of circRNA HECTD1 (circHECTD1) in UC. Methods Colonic mucosal tissues of 60 patients with active UC and 30 healthy controls were collected for H&E staining. Lipopolysaccharide (LPS) and dextran sulfate sodium (DSS) were used to induce inflammation and UC in Caco-2 cells and C57BL/6 mice where modification of circHECTD1, miR-182–5p and/or human antigen R (HuR) took place. The Caco-2 cells and the colon tissues of DSS-treated mice were collected for analysis of the expression levels of inflammatory cytokines, NLRP3 inflammasome, and autophagy-related proteins. The interactions among circHECTD1, miR-182–5p, and HuR were verified. Results The colonic mucosal tissues of UC patients showed impaired autophagy and decreased expressions of circHECTD1 and HuR. Overexpression of circHECTD1 or HuR or inhibition of miR-182–5p suppressed inflammation and promoted autophagy of LPS-induced Caco-2 cells. The expression of HuR was promoted by circHECTD1 via miR-182–5p in Caco-2 cells. Overexpression of circHECTD1 reduced colonic injuries and inflammation by promoting autophagy in DSS-treated mice. Conclusion Overexpression of circHECTD1 alleviates UC by promoting HuR-dependent autophagy via miR-182–5p. This study highlights the therapeutic potential of circHECTD1 for UC and adds to the knowledge of circRNA in the pathogenesis of UC.

Oral administration of Lentinus edodes β-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARγ pathways

2016 ◽  
Vol 7 (11) ◽  
pp. 4614-4627 ◽  
Author(s):  
Limin Shi ◽  
Qinlu Lin ◽  
Tao Yang ◽  
Ying Nie ◽  
Xinhua Li ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Oral Administration ◽  
Molecular Mechanism ◽  
Sodium Salt ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Lentinus Edodes ◽  
Raw264.7 Cell ◽  
Colitis Model ◽  
Inflammatory Effect

To evaluate the anti-inflammatory effect of β-glucans fromLentinus edodes, and its molecular mechanism, the dextran sulfate sodium salt (DSS) induced colitis model of mice and the LPS-stimulated RAW264.7 cell inflammation model were used in this study.

Prophylactic role of curcumin in dextran sulfate sodium (DSS)-induced ulcerative colitis murine model

2009 ◽  
Vol 47 (6) ◽  
pp. 1311-1317 ◽  
Author(s):  
Hossam M.M. Arafa ◽  
Ramadan A. Hemeida ◽  
Ali I.M. El-Bahrawy ◽  
Farid M.A. Hamada
Keyword(s):  
Ulcerative Colitis ◽  
Murine Model ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium

Protective role of G-CSF in dextran sulfate sodium-induced acute colitis through generating gut-homing macrophages

Cytokine ◽  
2016 ◽  
Vol 78 ◽  
pp. 69-78 ◽  
Author(s):  
Shahab Meshkibaf ◽  
Andrew J. Martins ◽  
Garth T. Henry ◽  
Sung Ouk Kim
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Protective Role ◽  
Acute Colitis

Tu1281 - The Protective Role of Nadph Oxidase 4 in Dextran Sulfate Sodium-Induced Colitis Mouse Model

2018 ◽  
Vol 154 (6) ◽  
pp. S-923
Author(s):  
Yura Lee ◽  
Sungsook Yu ◽  
Kwang Hui Kim ◽  
Yejin Cho ◽  
Haeng Dueng Jeong ◽  
...  
Keyword(s):  
Mouse Model ◽  
Nadph Oxidase ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Protective Role ◽  
Nadph Oxidase 4
Sign in / Sign up

Export Citation Format

Share Document