Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis through inhibition of the myocardial NF-κB/TGF-β1/Smad signaling pathway

2019 ◽  
Vol 10 (2) ◽  
pp. 1179-1190 ◽  
Author(s):  
Jia Wang ◽  
Wei Shen ◽  
Jun-Yan Zhang ◽  
Chang-Hao Jia ◽  
Mei-Lin Xie
Keyword(s):  
Signaling Pathway ◽  
Myocardial Fibrosis ◽  
Antioxidant Ability ◽  
Smad Signaling ◽  
Synergistic Inhibition ◽  
Smad Signaling Pathway ◽  
Smad7 Expression ◽  
Tgf Β1

Stevioside attenuates isoproterenol-induced mouse myocardial fibrosis, and its mechanisms are associated with the increments of antioxidant ability, PPARγ activation, and Smad7 expression, which cause a synergistic inhibition of the NF-κB/TGF-β1/Smad signaling pathway.

Forsythiaside B inhibits myocardial fibrosis via down regulating TGF-β1/Smad signaling pathway

2021 ◽  
pp. 174354
Author(s):  
Jing Sun ◽  
Jiaxin Zhu ◽  
Lei Chen ◽  
Bingjing Duan ◽  
Ruyi Wang ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Myocardial Fibrosis ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1

scholarly journals Salvanic acid B inhibits myocardial fibrosis through regulating TGF-β1/Smad signaling pathway

2019 ◽  
Vol 110 ◽  
pp. 685-691 ◽  
Author(s):  
Hongyan Gao ◽  
Zhe Bo ◽  
Qin Wang ◽  
Ling Luo ◽  
Haiyi Zhu ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Myocardial Fibrosis ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1

scholarly journals KGF-1 accelerates wound contraction through the TGF-β1/Smad signaling pathway in a double-paracrine manner

2019 ◽  
Vol 294 (21) ◽  
pp. 8361-8370 ◽  
Author(s):  
Yi Peng ◽  
Song Wu ◽  
Qiyu Tang ◽  
Shuaihua Li ◽  
Cheng Peng
Keyword(s):  
Signaling Pathway ◽  
Wound Contraction ◽  
Smad Signaling ◽  
Smad Signaling Pathway ◽  
Tgf Β1

scholarly journals Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κB-TGF-β1/Smad Signaling Pathway

2020 ◽  
Vol 21 (2) ◽  
pp. 402 ◽  
Author(s):  
Yi Quan ◽  
Woong Park ◽  
Jixiu Jin ◽  
Won Kim ◽  
Sung Kwang Park ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Ureteral Obstruction ◽  
Renal Fibrosis ◽  
Mitochondrial Dynamics ◽  
Unilateral Ureteral Obstruction ◽  
Sirtuin 3 ◽  
Smad Signaling ◽  
Renal Tubulointerstitial Fibrosis ◽  
Smad Signaling Pathway ◽  
Tgf Β1

Renal fibrosis is a common feature of all progressive chronic kidney diseases. Sirtuin 3 (SIRT3) is one of the mitochondrial sirtuins, and plays a role in the regulation of mitochondrial biogenesis, oxidative stress, fatty acid metabolism, and aging. Recently, honokiol (HKL), as a pharmaceutical SIRT3 activator, has been observed to have a protective effect against pressure overload-induced cardiac hypertrophy by increasing SIRT3 activity. In this study, we investigated whether HKL, as a SIRT3 activator, also has protective effects against unilateral ureteral obstruction (UUO)-induced renal tubulointerstitial fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the nuclear factor-κB (NF-κB)/transforming growth factor-β1 (TGF-β1)/Smad signaling pathway. We found that HKL decreased the UUO-induced increase in tubular injury and extracellular matrix (ECM) deposition in mice. HKL also decreased myofibroblast activation and proliferation in UUO kidneys and NRK-49F cells. Finally, we showed that HKL treatment decreased UUO-induced mitochondrial fission and promoted mitochondrial fusion through SIRT3-dependent effects. In conclusion, activation of SIRT3 via HKL treatment might have beneficial effects on UUO-induced renal fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the NF-κB/TGF-β1/Smad signaling pathway.

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