Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation

2019 ◽  
Vol 10 (5) ◽  
pp. 2970-2985 ◽  
Author(s):  
Chenxu Ge ◽  
Minxuan Xu ◽  
Yuting Qin ◽  
Tingting Gu ◽  
Deshuai Lou ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Diabetic Nephropathy ◽  
Renal Disease ◽  
High Fat Diet ◽  
Cellular Responses ◽  
High Fat ◽  
Caloric Excess

Obesity-related renal disease is related to caloric excess promoting deleterious cellular responses.

Altered bone metabolism after high fat diet and exercise: role of Wnt signaling and insulin resistance

2016 ◽  
Author(s):  
Ann-Kristin Picke ◽  
Lykke Sylow ◽  
Lisbeth L V Moller ◽  
Rasmus Kjobsted ◽  
Erik Richter ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Wnt Signaling ◽  
Bone Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Diet And Exercise

Odontella aurita-enriched high-fat diet prevents high-fat diet induced insulin resistance

2015 ◽  
Author(s):  
Hamza Amine ◽  
Yacir Benomar ◽  
Nadia Meskini ◽  
Mohammed Taouis
Keyword(s):  
Insulin Resistance ◽  
High Fat Diet ◽  
High Fat ◽  
Odontella Aurita

165-OR: The Mechanisms by Which Adiponectin Reverses Insulin Resistance in High-Fat Diet Fed Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 165-OR
Author(s):  
XIRUO LI ◽  
DONGYAN ZHANG ◽  
RACHEL J. PERRY ◽  
DANIEL F. VATNER ◽  
LEIGH GOEDEKE ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Fat Diet ◽  
High Fat

Insulin resistance of muscle glucose transport in rats fed a high-fat diet: a reevaluation

Diabetes ◽  
1997 ◽  
Vol 46 (11) ◽  
pp. 1761-1767 ◽  
Author(s):  
D. H. Han ◽  
P. A. Hansen ◽  
H. H. Host ◽  
J. O. Holloszy
Keyword(s):  
Insulin Resistance ◽  
Glucose Transport ◽  
High Fat Diet ◽  
High Fat ◽  
Muscle Glucose Transport

Anti-obesity effects of Grifola frondosa through the modulation of lipid metabolism via ceramide in mice fed a high-fat diet

2021 ◽  
Author(s):  
Xue Jiang ◽  
Jie Hao ◽  
Zijian Liu ◽  
Xueting Ma ◽  
Yuxin Feng ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Fat Deposition ◽  
Grifola Frondosa ◽  
High Fat ◽  
Metabolic Complications ◽  
Basidiomycete Fungus

Obesity is characterized by massive fat deposition and is related to a series of metabolic complications, such as insulin resistance (IR) and steatohepatitis. Grifola frondosa (GF) is a basidiomycete fungus...

scholarly journals Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus

2021 ◽  
Author(s):  
Longmin Chen ◽  
Jing Zhang ◽  
Yuan Zou ◽  
Faxi Wang ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
High Fat Diet ◽  
Macrophage Polarization ◽  
Fatty Acid Uptake ◽  
Chromatin Accessibility ◽  
Acid Uptake ◽  
High Fat ◽  
M2 Polarization ◽  
Adipose Tissue Macrophages ◽  
Cold Challenge

AbstractKdm2a catalyzes H3K36me2 demethylation to play an intriguing epigenetic regulatory role in cell proliferation, differentiation, and apoptosis. Herein we found that myeloid-specific knockout of Kdm2a (LysM-Cre-Kdm2af/f, Kdm2a−/−) promoted macrophage M2 program by reprograming metabolic homeostasis through enhancing fatty acid uptake and lipolysis. Kdm2a−/− increased H3K36me2 levels at the Pparg locus along with augmented chromatin accessibility and Stat6 recruitment, which rendered macrophages with preferential M2 polarization. Therefore, the Kdm2a−/− mice were highly protected from high-fat diet (HFD)-induced obesity, insulin resistance, and hepatic steatosis, and featured by the reduced accumulation of adipose tissue macrophages and repressed chronic inflammation following HFD challenge. Particularly, Kdm2a−/− macrophages provided a microenvironment in favor of thermogenesis. Upon HFD or cold challenge, the Kdm2a−/− mice manifested higher capacity for inducing adipose browning and beiging to promote energy expenditure. Collectively, our findings demonstrate the importance of Kdm2a-mediated H3K36 demethylation in orchestrating macrophage polarization, providing novel insight that targeting Kdm2a in macrophages could be a viable therapeutic approach against obesity and insulin resistance.

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