Licochalcone A inhibits the invasive potential of human glioma cells by targeting the MEK/ERK and ADAM9 signaling pathways

2018 ◽  
Vol 9 (12) ◽  
pp. 6196-6204 ◽  
Author(s):  
Chien-Feng Huang ◽  
Shun-Fa Yang ◽  
Hui-Ling Chiou ◽  
Wen-Hung Hsu ◽  
Jen-Chieh Hsu ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Invasive Potential ◽  
Licochalcone A ◽  
Antitumor Properties

Licochalcone A (LicA) has been reported to possess antitumor properties.

PAX3 Promotes Proliferation of Human Glioma Cells by WNT/β-Catenin Signaling Pathways

2019 ◽  
Vol 68 (1) ◽  
pp. 66-77 ◽  
Author(s):  
Xia Liang ◽  
Zhao Dong ◽  
Wu Bin ◽  
Nie Dekang ◽  
Zhu Xuhang ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells

scholarly journals Mig-2 attenuates cisplatin-induced apoptosis of human glioma cells in vitro through AKT/JNK and AKT/p38 signaling pathways

2014 ◽  
Vol 35 (9) ◽  
pp. 1199-1206 ◽  
Author(s):  
Yun-wei Ou ◽  
Zi-tong Zhao ◽  
Chuan-yue Wu ◽  
Bai-nan Xu ◽  
Yong-mei Song ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Induced Apoptosis

Mutant IκBα Suppresses Hypoxia-Induced VEGF Expression Through Downregulation of HIF-1α and COX-2 in Human Glioma Cells

2005 ◽  
Vol 15 (3) ◽  
pp. 139-149 ◽  
Author(s):  
Yoshihira Kimba ◽  
Tatsuya Abe ◽  
Jian Liang Wu ◽  
Ryo Inoue ◽  
Minoru Fukiki ◽  
...  
Keyword(s):  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Vegf Expression ◽  
Cox 2

scholarly journals Differential expression and role of p21cip/waf1 and p27kip1 in TNF-α-induced inhibition of proliferation in human glioma cells

2007 ◽  
Vol 6 (1) ◽  
pp. 42 ◽  
Author(s):  
Pabbisetty Kumar ◽  
Anjali Shiras ◽  
Gowry Das ◽  
Jayashree C Jagtap ◽  
Vandna Prasad ◽  
...  
Keyword(s):  
Differential Expression ◽  
Glioma Cells ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Inhibition Of Proliferation ◽  
Tnf Α

scholarly journals Indirubin exerts anticancer effects on human glioma cells by inducing apoptosis and autophagy

AMB Express ◽  
2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Zhaohui Li ◽  
Han Wang ◽  
Jun Wei ◽  
Liang Han ◽  
Zhigang Guo
Keyword(s):  
Apoptotic Cell ◽  
Treatment Strategies ◽  
Glioma Cells ◽  
Annexin V ◽  
Metastatic Potential ◽  
Human Glioma ◽  
Human Glioma Cells ◽  
Efficient Treatment ◽  
Cell Percentage ◽  
Anticancer Effects

Abstract Glioma causes significant mortality across the world and the most aggressive type of brain cancer. The incidence of glioma is believed to increase in the next few decades and hence more efficient treatment strategies need to be developed for management of glioma. Herein, we examined the anticancer effects of Indirubin against a panel of human glioma cells and attempted to explore the underlying mechanisms. The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay showed that Indirubin could inhibit the growth of all the glioma cells but the lowest IC50 of 12.5 µM was observed against the U87 and U118 glioma cells. Additionally, the cytotoxic effects of Indirubin were comparatively negligible against the normal astrocytes with an IC50 of > 100 µM. Investigation of mechanism of action, revealed that Indirubin exerts growth inhibitory effects on the U87 and U118 glioma cells by autophagic and apoptotic cell death. Annexin V/PI staining assay showed that apoptotic cell percentage increased dose dependently. Apoptosis was associated with increase in Bax decrease in Bcl-2 expressions. Additionally, the expression of autophagic proteins such as LC3II, ATG12, ATG15 and Beclin 1 was also increased. Wound heal assay showed that Indirubin caused remarkable decrease in the migration of the U87 and U118 cells indicative of anti-metastatic potential of Indirubin. Taken together, these results suggest that Indirubin exerts potent anticancer effects on glioma cells and may prove essential in the management of glioma.

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