Alleviation of paraquat-induced oxidative lung injury by betaineviaregulation of sulfur-containing amino acid metabolism despite the lack of betaine-homocysteine methyltransferase (BHMT) in the lung

2019 ◽  
Vol 10 (2) ◽  
pp. 1225-1234
Author(s):  
Jong Deok Na ◽  
Yeo Jin Choi ◽  
Doo Sung Jun ◽  
Young Chul Kim
Keyword(s):  
Amino Acid ◽  
Lung Injury ◽  
Antioxidant Capacity ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Betaine Homocysteine Methyltransferase ◽  
Sulfur Containing ◽  
Homocysteine Methyltransferase

Betaine regulates sulfur-containing amino acid metabolism in the lung despite the lack of BHMT and increases pulmonary antioxidant capacity.

scholarly journals Current Therapeutics, Their Problems, and Sulfur-Containing-Amino-Acid Metabolism as a Novel Target against Infections by “Amitochondriate” Protozoan Parasites

2007 ◽  
Vol 20 (1) ◽  
pp. 164-187 ◽  
Author(s):  
Vahab Ali ◽  
Tomoyoshi Nozaki
Keyword(s):  
Drug Resistance ◽  
Amino Acid ◽  
Trichomonas Vaginalis ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Protozoan Parasites ◽  
Novel Target ◽  
Sulfur Containing

SUMMARY The “amitochondriate” protozoan parasites of humans Entamoeba histolytica, Giardia intestinalis, and Trichomonas vaginalis share many biochemical features, e.g., energy and amino acid metabolism, a spectrum of drugs for their treatment, and the occurrence of drug resistance. These parasites possess metabolic pathways that are divergent from those of their mammalian hosts and are often considered to be good targets for drug development. Sulfur-containing-amino-acid metabolism represents one such divergent metabolic pathway, namely, the cysteine biosynthetic pathway and methionine γ-lyase-mediated catabolism of sulfur-containing amino acids, which are present in T. vaginalis and E. histolytica but absent in G. intestinalis. These pathways are potentially exploitable for development of drugs against amoebiasis and trichomoniasis. For instance, l-trifluoromethionine, which is catalyzed by methionine γ-lyase and produces a toxic product, is effective against T. vaginalis and E. histolytica parasites in vitro and in vivo and may represent a good lead compound. In this review, we summarize the biology of these microaerophilic parasites, their clinical manifestation and epidemiology of disease, chemotherapeutics, the modes of action of representative drugs, and problems related to these drugs, including drug resistance. We further discuss our approach to exploit unique sulfur-containing-amino-acid metabolism, focusing on development of drugs against E. histolytica.

Early galactooligosaccharide intervention alters the metabolic profile, improves the antioxidant capacity of mitochondria and activates the AMPK/Nrf2 signaling pathway in suckling piglet liver

2020 ◽  
Vol 11 (8) ◽  
pp. 7280-7292
Author(s):  
Jue Wang ◽  
Shiyi Tian ◽  
Jing Wang ◽  
Weiyun Zhu
Keyword(s):  
Amino Acid ◽  
Antioxidant Capacity ◽  
Signaling Pathway ◽  
Metabolic Profile ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Lipid Catabolism ◽  
Nrf2 Signaling Pathway ◽  
Suckling Piglets ◽  
Suckling Piglet

The early GOS intervention altered the composition of the hepatic metabolic profile by promoting lipid catabolism and regulating amino acid metabolism in the suckling piglets.

Amino Acid Metabolism

1979 ◽  
Vol 7 (1) ◽  
pp. 261-262
Author(s):  
E. V. ROWSELL
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Effect of intravenous bicarbonate administration on postoperative amino acid metabolism

1985 ◽  
Vol 4 ◽  
pp. 141-146 ◽  
Author(s):  
K VESTERBERG ◽  
J BERGSTROM ◽  
P FURST ◽  
U LEANDER ◽  
E VINNARS
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism
Sign in / Sign up

Export Citation Format

Share Document