The ameliorative effect of a Lactobacillus strain with good adhesion ability against dextran sulfate sodium-induced murine colitis

2019 ◽  
Vol 10 (1) ◽  
pp. 397-409 ◽  
Author(s):  
Guangqiang Wang ◽  
Yingnan Liu ◽  
Zhi Lu ◽  
Yiting Yang ◽  
Yongjun Xia ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Good Adhesion ◽  
Disease Symptoms ◽  
Murine Colitis ◽  
Adhesion Ability ◽  
Ameliorative Effect ◽  
Excellent Adhesion ◽  
Colitis Model

The objective of this study was to effectively screen out a Lactobacillus strain with excellent adhesion ability and ameliorative effect on the disease symptoms of a murine ulcerative colitis model.

Effects of Lactobacillus gasseri SBT2055 on Dextran Sulfate Sodium-Induced Ulcerative Colitis Model in Rats

2002 ◽  
Vol 21 (3) ◽  
pp. 179-183 ◽  
Author(s):  
Eiichi IMAI ◽  
Kenji FUKUI ◽  
Noriyasu OHTA ◽  
Toshie TOMITSUKA ◽  
Yasuyuki SETO ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Lactobacillus Gasseri ◽  
Colitis Model

scholarly journals Molecular and Microbial Signatures Predictive of Prebiotic Action of Neoagarotetraose in a Dextran Sulfate Sodium-Induced Murine Colitis Model

2020 ◽  
Vol 8 (7) ◽  
pp. 995
Author(s):  
Fang Liu ◽  
Jianan Liu ◽  
Thomas T.Y. Wang ◽  
Zhen Liu ◽  
Changhu Xue ◽  
...  
Keyword(s):  
Gut Microbiome ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Intestinal Inflammation ◽  
16S Rrna Gene Sequencing ◽  
Rrna Gene ◽  
Murine Colitis ◽  
Bioactive Properties ◽  
Rrna Gene Sequencing ◽  
Colitis Model

Neoagarotetraose (NT), a hydrolytic product of agar by β-agarase, is known to possess bioactive properties. However, the mechanisms via which NT alleviates intestinal inflammation remain unknown. In this study, a dextran sulfate sodium (DSS)-induced murine model was developed to evaluate the effect of NT on gut microbiome and microbial metabolism using 16S rRNA gene sequencing and untargeted metabolomics. Our data demonstrate that NT ingestion improved gut integrity and inflammation scores. NT reversed the abundance of Proteobacteria from an elevated level induced by DSS and significantly increased the abundance of Verrucomicrobia. Further, NT significantly increased the abundance of Akkermansia and Lactobacillus and concomitantly decreased that of Sutterella, which were among the important features identified by random forests analysis contributing to classification accuracy for NT supplementation. A microbial signature consisting of Adlercreutzia (denominator) and Turicibacter (numerator) predicted the NT supplementation status. Moreover, NT significantly modulated multiple gut metabolites, particularly those related to histidine, polyamine and tocopherol metabolism. Together, our findings provided novel insights into the mechanisms by which NT modulated the gut microbiome and metabolome and should facilitate the development of NT as a potent prebiotic for colitis management.

Oral administration of Lentinus edodes β-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARγ pathways

2016 ◽  
Vol 7 (11) ◽  
pp. 4614-4627 ◽  
Author(s):  
Limin Shi ◽  
Qinlu Lin ◽  
Tao Yang ◽  
Ying Nie ◽  
Xinhua Li ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Oral Administration ◽  
Molecular Mechanism ◽  
Sodium Salt ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Lentinus Edodes ◽  
Raw264.7 Cell ◽  
Colitis Model ◽  
Inflammatory Effect

To evaluate the anti-inflammatory effect of β-glucans fromLentinus edodes, and its molecular mechanism, the dextran sulfate sodium salt (DSS) induced colitis model of mice and the LPS-stimulated RAW264.7 cell inflammation model were used in this study.

Beneficial and preventive effect of chitin nanofibrils in a dextran sulfate sodium-induced acute ulcerative colitis model

2012 ◽  
Vol 87 (2) ◽  
pp. 1399-1403 ◽  
Author(s):  
Kazuo Azuma ◽  
Tomohiro Osaki ◽  
Takashi Wakuda ◽  
Shinsuke Ifuku ◽  
Hiroyuki Saimoto ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Preventive Effect ◽  
Colitis Model

scholarly journals A murine colitis model developed using a combination of dextran sulfate sodium and Citrobacter rodentium

2018 ◽  
Vol 56 (4) ◽  
pp. 272-279
Author(s):  
Jin-Il Park ◽  
Sun-Min Seo ◽  
Jong-Hyung Park ◽  
Hee-Yeon Jeon ◽  
Jun-Young Kim ◽  
...  
Keyword(s):  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Citrobacter Rodentium ◽  
Murine Colitis ◽  
Colitis Model

Substance P failed to reverse dextran sulfate sodium-induced murine colitis mediated by mitochondrial dysfunction: implications in ulcerative colitis

3 Biotech ◽  
2021 ◽  
Vol 11 (4) ◽  
Author(s):  
Spoorthi B. Chandraiah ◽  
Shashwati Ghosh ◽  
Ishita Saha ◽  
Sunil S. More ◽  
Gautham S. Annappa ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Substance P ◽  
Mitochondrial Dysfunction ◽  
Dextran Sulfate ◽  
Dextran Sulfate Sodium ◽  
Murine Colitis
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