Effects of oat protein supplementation on skeletal muscle damage, inflammation and performance recovery following downhill running in untrained collegiate men

2018 ◽  
Vol 9 (9) ◽  
pp. 4720-4729 ◽  
Author(s):  
Z. Xia ◽  
J. M. Cholewa ◽  
D. Dardevet ◽  
T. Huang ◽  
Y. Zhao ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Protein Supplementation ◽  
Protective Effects ◽  
Skeletal Muscle Damage ◽  
Downhill Running ◽  
Performance Recovery ◽  
And Performance

Oat protein supplementation exhibits protective effects on muscles during eccentric exercise, but more research is needed to clarify the mechanism.

Polymethoxyflavones in orange peel extract prevent skeletal muscle damage induced by eccentric exercise in rats

2020 ◽  
Vol 85 (2) ◽  
pp. 440-446
Author(s):  
Toshihide Suzuki ◽  
Makoto Shimizu ◽  
Yoshio Yamauchi ◽  
Ryuichiro Sato
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Vastus Lateralis ◽  
Orange Peel ◽  
Skeletal Muscle Damage ◽  
Downhill Running ◽  
Exercise Induced ◽  
Orange Peel Extract ◽  
Peel Extract

ABSTRACT Polymethoxyflavones (PMFs) contained in the peel of citrus fruits have anti-inflammatory, anticancer, and antidepressant effects. However, their effects on skeletal muscle are unknown. We investigated whether PMFs could prevent skeletal muscle damage induced by eccentric exercise in rats. Downhill running for 90 min increased the levels of the inflammatory cytokines, monocyte chemotactic protein-1 (MCP-1), and interleukin-1β (IL-1β) in skeletal muscles, especially in vastus lateralis, and the plasma creatine kinase levels. These increases were attenuated by a single oral administration of orange peel extract (OPE) 30 min before downhill running. A mixture of nobiletin, sinensetin, 3,5,6,7,8,3′,4′-heptamethoxyflavone, and tangeretin, which are the major PMFs of OPE, also showed similar effects on muscle damage. These results suggest that OPE has a protective effect against eccentric exercise-induced skeletal muscle damage, and that the effects may be attributed to the 4 major PMFs.

scholarly journals PO-214 DDAH1 knockout has a protective effect on muscle damage caused by downhill running

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Hui Song ◽  
Xin Xu
Keyword(s):  
Skeletal Muscle ◽  
Grip Strength ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Time Of Day ◽  
Control Group ◽  
Dimethylarginine Dimethylaminohydrolase ◽  
Warm Up ◽  
Downhill Running ◽  
Access To Water

Objective Purpose：Downhill running can causes muscle damage, called delayed muscle damage and induced oxidative stress and inflammatory reaction, causing abnormity of skeletal muscle morphology, changing in blood biochemical indexes, and decreasing in function of skeletal muscle systolic. Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase (NOS) inhibitor, is degraded by dimethylarginine dimethylaminohydrolase 1 (DDAH1). There were new evidences demonstrated that DDAH1 is an important regulator of cell redox state and apoptosis. In summary, the study shown that DDAH1 is an important regulator of cell redox state and apoptosis. Emerging evidences suggests that DDAH1 controls cellular oxidative stress and apoptosis via a miR-21-dependent pathway. However, the effect and mechanism of DDAH1 on damage of skeletal muscle caused by downhill running is not clear enough. Thus，the purpose of this experiment was to determine the effect and mechanism of DDAH1 in downhill running. Keys: downhill running; delayed onset muscle soreness(DOMS); eccentric exercise; skeletal muscle. Methods Method: The experimental mice were 24 female C57 mice of 10 weeks old and 24 female DDAH1 hybrid knockout mice of 10 weeks old. DDAH1 KO mice used for this study was knockout of dimethylarginine dimethylaminohydrolase 1 compared with WT mice. Animals were fed standard laboratory chow and had access to water ad libitum. C57 mice were divided into 3 groups: C57 control, C57 48H, C57 120H; DDAH1 KO mice were divided into 3 groups: DDAH1 control, DDAH1 48H, DDAH1 120H. C57 and DDAH1 KO mice used for this study completed a single bout of downhill running exercise (20°, 17 m/min, 60 min), and gastrocnemius muscle, soleus muscle and quadriceps femoris muscle were collected 48 and 120 hours (H) postexercise (PE). C57control group and DDAH1 KO control group dose not exercise. Speed on the treadmill was gradually increased from 10 to 17m/min during a 7-min warm-up period (increased of 1m/min every minute). All experiments were conducted at approximately the same time of day. Maximal grip strength was measured ifor each groups. Grip strength testing was completed to detect post-eccentric exercise injury in C57 and DDAH1 KO mice. All results were analyzed by means of methods of histological and molecular biological. Results Method: The experimental mice were 24 female C57 mice of 10 weeks old and 24 female DDAH1 hybrid knockout mice of 10 weeks old. DDAH1 KO mice used for this study was knockout of dimethylarginine dimethylaminohydrolase 1 compared with WT mice. Animals were fed standard laboratory chow and had access to water ad libitum. C57 mice were divided into 3 groups: C57 control, C57 48H, C57 120H; DDAH1 KO mice were divided into 3 groups: DDAH1 control, DDAH1 48H, DDAH1 120H. C57 and DDAH1 KO mice used for this study completed a single bout of downhill running exercise (20°, 17 m/min, 60 min), and gastrocnemius muscle, soleus muscle and quadriceps femoris muscle were collected 48 and 120 hours (H) postexercise (PE). C57control group and DDAH1 KO control group dose not exercise. Speed on the treadmill was gradually increased from 10 to 17m/min during a 7-min warm-up period (increased of 1m/min every minute). All experiments were conducted at approximately the same time of day. Maximal grip strength was measured ifor each groups. Grip strength testing was completed to detect post-eccentric exercise injury in C57 and DDAH1 KO mice. All results were analyzed by means of methods of histological and molecular biological. Conclusions Conclusion: The DDAH1 knockout has a protective effect on delayed onset muscle soreness(DOMS) caused by downhill running, and accelerate the injury recovery.     

Honokiol protects rats against eccentric exercise-induced skeletal muscle damage by inhibiting NF-κB induced oxidative stress and inflammation

2009 ◽  
Vol 610 (1-3) ◽  
pp. 119-127 ◽  
Author(s):  
Jasson Chiang ◽  
Yuh-Chiang Shen ◽  
Yea-Hwey Wang ◽  
Yu-Chang Hou ◽  
Chien-Chih Chen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Skeletal Muscle Damage ◽  
Exercise Induced

scholarly journals Accelerated Recovery OF Skeletal Muscle Damage After Eccentric Exercise By BCAA Supplementation

2021 ◽  
Vol 53 (8S) ◽  
pp. 300-300
Author(s):  
Yunfeng Dong ◽  
Junqiang Qiu ◽  
Hao Wei ◽  
Rui Miao ◽  
Yan Cheng ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Skeletal Muscle Damage

scholarly journals Does hyperthermia increase skeletal muscle damage from eccentric exercise?

2015 ◽  
Vol 4 (S1) ◽  
Author(s):  
John W Castellani ◽  
Edward J Zambraski ◽  
Michael N Sawka ◽  
Maria L Urso
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Eccentric Exercise ◽  
Skeletal Muscle Damage

Cardiorespiratory and skeletal muscle damage due to COVID-19: making the urgent case for rehabilitation

2021 ◽  
pp. 1-14
Author(s):  
Rebeca Nunes Silva ◽  
Cássia Da Luz Goulart ◽  
Murilo Rezende Oliveira ◽  
Guilherme Yassuyuki Tacao ◽  
Guilherme Dionir Back ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Skeletal Muscle Damage ◽  
Urgent Case

Modifications in the Concentrations of Circulating Myoglobin after Treatment with Low Doses of Adriamycin

1985 ◽  
Vol 71 (5) ◽  
pp. 463-468 ◽  
Author(s):  
Giovanni Carulli ◽  
Aldo Clerico ◽  
Alessandra Marini ◽  
Maria Grazia Del Chicca ◽  
Renato Vanacore ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Cancer Patients ◽  
Muscle Damage ◽  
Low Doses ◽  
Skeletal Muscle Damage ◽  
Creatine Kinase Mb

The modifications in the concentration of circulating myoglobin have been studied by means of a radioimmunoassay in 15 cancer patients undergoing polychemotherapy including adriamycin. In 8 patients significant increases in myoglobin levels were found after injection of low doses of the drug (25-50 mg/m2). Moreover, a disturbance of the normal biorhythm of the protein was evident in 12 patients. Creatine kinase-MB was evaluated by means of a radioimmunoassay, but there was no relation between an increase in the isoenzyme and an increase in myoglobin. No ECG modifications were detected. These data indicate that the measurement of myoglobin may offer an indication of myocardial or skeletal muscle damage caused by adriamycin.

Isoform specific ALT measurement during liver and skeletal muscle damage

2012 ◽  
Vol 211 ◽  
pp. S48
Author(s):  
Björn Glinghammar ◽  
Ingalill Rafter ◽  
Ina Schuppe-Koistinen ◽  
Ian Cotgreave
Keyword(s):  
Skeletal Muscle ◽  
Muscle Damage ◽  
Skeletal Muscle Damage
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