The protective role ofOcimum basilicumL. (Basil) against aspirin-induced gastric ulcer in mice: Impact on oxidative stress, inflammation, motor deficits and anxiety-like behavior

2018 ◽  
Vol 9 (8) ◽  
pp. 4457-4468 ◽  
Author(s):  
Eman Ali Abd El-Ghffar ◽  
Eman Al-Sayed ◽  
Safia Mohamed Shehata ◽  
Omayma A. Eldahshan ◽  
Thomas Efferth
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
Protective Role ◽  
Ocimum Basilicum ◽  
Hexane Extract ◽  
Gastric Ulcers ◽  
Motor Deficits ◽  
Behavioral Alterations ◽  
Gastroprotective Effect ◽  
Ameliorative Effect

The gastroprotective effect ofOcimum basilicumL. (Basil) hexane extract (OBHE) in aspirin-induced gastric ulcers in mice and its ameliorative effect on behavioral alterations were determined.

scholarly journals Ameliorative effect of Albizzia procera leaves extract against experimentally induced gastric ulcer models in Wistar albino rats

2021 ◽  
Vol 13 (1) ◽  
pp. 308-315
Author(s):  
Vivek Srivastava ◽  
Santosh Kumar Verma ◽  
Neha Mathur ◽  
Kapil Kumar Goel
Keyword(s):  
Gastric Ulcer ◽  
Ethanolic Extract ◽  
Gastric Fluid ◽  
Gastric Ulcers ◽  
Albino Rats ◽  
Traditional Medicines ◽  
Pylorus Ligation ◽  
Ameliorative Effect ◽  
Wistar Albino Rats ◽  
Experimentally Induced

Albizzia procera belongs to family Fabaceae and has several phytoconstituents like flavonoids, terpenes, alkaloids, saponins etc. The plant is commonly used in traditional medicines. The objective of the present study was to assess the ameliorative effect of A. procera leaves extract against an experimentally induced gastric ulcer in albino rats. The antiulcer, antisecretory and cytoprotective properties of an ethanolic extract prepared from the leaves was evaluated. When given in a 200 mg/kg oral (per. os) dose, the extract produced 74% and 85% protection index in ethanol-induced ulcer model and pylorus ligation model, respectively.  Additionally, the extract also prohibited the formation of haemorrhage and edema, significantly lessened catalase activity (p<0.0001) and the lipid peroxidation level (p<0.0001) in the glandular tissue of Wistar albino rats. Furthermore, the extract also significantly diminished the total acidity(p<0.0001) of the gastric fluid by increasing its pH (p<0.0001). The occupancy of different phytoconstituents in the extract, such as flavonoids and tannins were identified that may be responsible for its gastro-protective activity. All these results provide a basis explaining the antiulcer ability of A. procera being useful in the management of gastric ulcers.

scholarly journals Gastroprotective Effects of the Aqueous Extract from Taraxacum officinale in Rats Using Ultrasound, Histology, and Biochemical Analysis

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Maria Eduarda D. C. Zanatta ◽  
Daniela Miorando ◽  
Amanda M. Stefller ◽  
Nátali Roos ◽  
Jackeline Ernetti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Aqueous Extract ◽  
Assessment Tool ◽  
Gastric Wall ◽  
Taraxacum Officinale ◽  
Gastric Ulcers ◽  
Phytochemical Analysis ◽  
Ultrasound Technique ◽  
Gastroprotective Effect ◽  
Biochemical Analyses

Taraxacum officinale F.H. Wigg. belonging to the family Asteraceae is an edible medicinal plant distributed worldwide. This study aimed to determine the gastroprotective effects of aqueous extract of T. officinale (AETo) in rats using ultrasound, histological, and biochemical analyses. In this study, gastric ulceration was induced by ethanol or piroxicam. Rats were then treated with AETo (3, 30, or 300 mg/kg). The area and histological appearance of gastric ulcers were quantified, and histochemical analysis was performed. The activity of AETo on inflammatory and oxidative stress markers was assessed in the ulcerated tissue. In addition, we investigated the thickness of the gastric wall using the ultrasound technique. Moreover, chemical analyses of AETo were performed. In rats with ethanol- or piroxicam-induced ulcers, AETo reduced the ulceration area, elevated mucin level, and the gastroprotective effect was confirmed by histological analysis. The gastroprotective effect was accompanied by increased activities of SOD, CAT, and GST, as well as an increase in GSH level and reduction in MPO activity. Furthermore, AETo reduced the thickness of the gastric wall in rats. Phytochemical analysis of AETo indicated phenolic acids and flavonoids as the main active compounds. In conclusion, the gastroprotective effect of AETo involves reduction in oxidative stress and inflammatory injury and increase in mucin content. This study advances in the elucidation of mechanisms of gastric protection of T. officinale, contributes to the prospection of new molecules gastroprotective, and proposes the ultrasonographic analyses as a new gastroprotective assessment tool in preclinical studies.

Protective Role of Casuarinin from Melaleuca leucadendra against Ethanol-Induced Gastric Ulcer in Rats

Planta Medica ◽  
2019 ◽  
Vol 86 (01) ◽  
pp. 32-44 ◽  
Author(s):  
Eman Al-Sayed ◽  
Haidy E. Michel ◽  
Mohamed Abdelrazik Khattab ◽  
Mohamed El-Shazly ◽  
Abdel Nasser Singab
Keyword(s):  
Gastric Ulcer ◽  
Health Problem ◽  
Treatment Options ◽  
Protective Role ◽  
Current Treatment ◽  
Gastric Ulcers ◽  
Major Health Problem ◽  
Histamine H2 Receptor ◽  
Ulcer Group ◽  
Melaleuca Leucadendra

AbstractGastric ulcer is a major health problem. Current treatment options of gastric ulcer, including antagonists of histamine H2 receptor and inhibitors of the proton pump, do not cure gastric ulcers, but only provide temporary relief of symptoms and can be associated with severe side effects. The lack of effective and safe medications for this global health problem urges for the discovery of novel classes of compounds with potent activity and an acceptable safety profile. Ethanol-induced ulceration in rats was used to evaluate the gastroprotective activity of casuarinin, an ellagitannin isolated from Melaleuca leucadendra. Casuarinin (25, 50, and 100 mg/kg) reduced the ulcer area by 45, 78, and 99%, respectively, compared with the ulcer group. Casuarinin (100 mg/kg) increased mucin content by 1.8-fold and reduced acidity by 42%. At the same dose, it also increased the levels of reduced glutathione by 194%, catalase by 586%, and prostaglandin E2 to its normal level. In contrast, it attenuated the ethanol-increased levels of malondialdehyde by 56%, TNF-α by 58%, and caspase-3 by 87%. Histological findings demonstrated that casuarinin exhibited a protective effect against tissue alterations in response to the ethanol-induced ulcer. Casuarinin suppressed the immunoexpression of nuclear factor-kappa B, cyclooxygenase-2, and inducible nitric oxide synthase to their normal values. It also induced the expression of heat shock protein-70, reaching up to 4.9-fold in comparison with the ulcer group. The potent gastroprotective effect of casuarinin was thus attributed to its anti-inflammatory, antioxidant, and antiapoptotic effects. Our results suggest the potential application of casuarinin as an antiulcer agent from natural sources.

scholarly journals Evaluation of Neuroprotective Effects of Quercetin against Aflatoxin B1-Intoxicated Mice

Animals ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 898 ◽  
Author(s):  
Enrico Gugliandolo ◽  
Alessio Filippo Peritore ◽  
Ramona D’Amico ◽  
Patrizia Licata ◽  
Rosalia Crupi
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Aflatoxin B1 ◽  
Protective Effects ◽  
Behavioral Alterations ◽  
Sod Activity ◽  
Neuroprotective Effects ◽  
Oxidative Stress Pathway ◽  
Ameliorative Effect ◽  
The Brain

Aflatoxin B1 (AFB1) is a mycotoxin commonly present in feed, characterized by several toxic effects. AFB1 seems to have a neurotoxical effect that leads to memory impairment behavior. AFB1 toxicity involves the induction of the oxidative stress pathway, rising lipid peroxidation, and it decreases antioxidant enzyme levels. Hence, in our research, we wanted to evaluate the potential protective effects of quercetin 30 mg/kg in AFB1-mediated toxicity in the brain and the ameliorative effect on behavioral alterations. Oral supplementation with quercetin increased glutathione peroxidase (GSH) levels, superoxidedismutase (SOD) activity and catalase (CAT) in the brain, and it reduced lipid peroxidation in AFB1-treated mice. This antioxidant effect of quercetin in the brains of AFB1-intoxicated mice is reflected in better cognitive and spatial memory capacity, as well as a better profile of anxiety and lethargy disorders. In conclusion, our study suggests that quercetin exerts a preventive role against oxidative stress by promoting antioxidative defense systems and limiting lipid peroxidation.

scholarly journals Beneficial Effects of Curcumin in Maternal and Fetal Oxidative Stress and Brain Damage Induced by Gestational Lead Administration

2018 ◽  
Vol 11 (2) ◽  
pp. 871-887 ◽  
Author(s):  
Hamid A. Saleh ◽  
Gamal S. Abd El-Aziz ◽  
Hehsam N. Mustafa ◽  
Magdy El-Fark ◽  
Jawad Mansour Tashkandi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Role ◽  
Significant Rise ◽  
Female Rats ◽  
Control Group ◽  
Antioxidant Enzyme Activities ◽  
Histopathological Changes ◽  
Pregnant Rats ◽  
Beneficial Effects ◽  
Ameliorative Effect

This study was planned to explore the protective role of curcumin (Cur) against maternal and fetal oxidative stress and cerebral damage induced by lead (Pb) during pregnancy. Positively pregnant female rats were divided into seven groups: control group, Cur group (300 mg/kg of Cur/b.wt.), DMSO group (50% DMSO), two Pb-treated groups (exposed to 160 and 320 mg/kg b.wt./day of Pb acetate, respectively), and two groups treated with both Pb and Cur (exposed to Pb as previous groups together with 300 mg/kg b.wt./day of Cur). Treatments through oral gavage once a day started from gestation day 1 (GD1) till day 20 (GD20), where the mother rats of different experimental groups were sacrificed to obtain the fetuses. Different chemical parameters were assessed. Brain specimens of mother and fetal groups were processed with examination. The results displayed that Pb administration to pregnant rats resulted in a dose-dependent toxicity for both mothers and fetuses. Also, there was a significant rise in lipid peroxidation and decreased antioxidant enzyme activities in the brains of the different Pb-treated groups. The histological examination of the brain of treated dams and fetuses showed marked alterations. Co-treatment of Cur along with Pb caused a significant decrease in Pb levels as compared with those treated with Pb alone, improving the oxidative condition with amelioration of the brain’s histopathological changes. Co-administration of Cur could have ameliorative effect against Pb-induced neurotoxicity through the reduction of oxidative stress and reversal of histopathological changes.

scholarly journals Pharmacodynamics and Pharmacokinetics of a New Type of Compound Lansoprazole Capsule in Gastric Ulcer Rats and Beagle Dogs: Importance of Adjusting Oxidative Stress and Inflammation

Pharmaceutics ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 49
Author(s):  
Binbin Wei ◽  
Yan Wang ◽  
Huizhe Wu ◽  
Mingyan Liu ◽  
Weifan Yao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
Positive Influence ◽  
Gastric Ulcers ◽  
Histological Evaluation ◽  
Pharmacokinetic Parameters ◽  
Beagle Dogs ◽  
Rapid Absorption ◽  
Dog Plasma ◽  
New Type

: The aim of this study was to investigate the pharmacodynamics and pharmacokinetics of a new type of compound lansoprazole capsule in gastric ulcer rats and beagle dogs in order to confirm whether it is more effective in treating gastric ulcers and its rapid absorption. A rat model of gastric ulcers was used to evaluate the anti-ulcerogenic effect of the compound lansoprazole capsule. A fast and sensitive UPLC-MS/MS method was developed to detect lansoprazole in dog plasma. Macroscopic and histological evaluation results revealed that the compound lansoprazole capsule is more effective in treating gastric ulcers as it was able to significantly reduce the gastric ulcer compared to the other groups. Additionally, it was able to enhance the expression of the antioxidant enzyme superoxide dismutase (SOD) and suppress lipid peroxidation as indicated by the reduction of malondialdehyde (MDA) and H+-K+-ATP activity. Furthermore, this capsule increased the expression of mucosal vascular endothelial growth factor (VEGF) and cyclic oxygenase 2 (COX-2). The established UPLC-MS/MS method was successfully applied to the evaluation of pharmacokinetic parameters of lansoprazole in beagle dogs. The results indicate that the compound lansoprazole capsule had an advantage of rapid absorption. This study demonstrated that the compound lansoprazole capsule has better gastroprotective activity and that this might be related to its positive influence on oxidative stress and inflammation. This new type of compound lansoprazole capsule may be potentially useful in preclinical therapy.

Ameliorative effect of Boesenbergin A, a chalcone isolated from Boesenbergia rotunda (Fingerroot) on oxidative stress and inflammation in ethanol-induced gastric ulcer in vivo

2020 ◽  
Vol 261 ◽  
pp. 113104 ◽  
Author(s):  
Syam Mohan ◽  
Yahya Hasan Hobani ◽  
Emad Shaheen ◽  
Alaa Sayed Abou-Elhamd ◽  
Aymen abdelhaleem ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Gastric Ulcer ◽  
Ameliorative Effect ◽  
Boesenbergia Rotunda
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