scholarly journals Spiers Memorial Lecture : Introductory lecture: the impact of structure on photoinduced processes in nucleic acids and proteins

2018 ◽  
Vol 207 ◽  
pp. 9-26
Author(s):  
Tatiana Domratcheva ◽  
Ilme Schlichting
Keyword(s):  
Nucleic Acids ◽  
Memorial Lecture ◽  
Introductory Lecture ◽  
The Impact ◽  
Photoinduced Processes

This review gives an overview of the impact of structure on the understanding of photoinduced processes in macromolecules, focusing on systems presented at this Faraday Discussion meeting.

The impact of non-tumor-derived circulating nucleic acids implicates the prognosis of non-small cell lung cancer

2012 ◽  
Vol 139 (1) ◽  
pp. 67-76 ◽  
Author(s):  
Chanida Vinayanuwattikun ◽  
Pakorn Winayanuwattikun ◽  
Poonchavist Chantranuwat ◽  
Apiwat Mutirangura ◽  
Virote Sriuranpong
Keyword(s):  
Lung Cancer ◽  
Nucleic Acids ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Circulating Nucleic Acids ◽  
The Impact

scholarly journals The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Drahomira Holmannova ◽  
Lenka Borska ◽  
Ctirad Andrys ◽  
Pavel Borsky ◽  
Jan Kremlacek ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Serum Level ◽  
Oxidative Damage ◽  
Nucleic Acids ◽  
Systemic Inflammation ◽  
Serum Levels ◽  
Enzyme Linked Immunosorbent Assay ◽  
Wide Range ◽  
Systemic Inflammatory Disease ◽  
The Impact

Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases. The presented study describes the influence of psoriasis and MetS on the serum levels of markers of systemic inflammation (calprotectin and ANGPTL8) and markers of oxidative damage to nucleic acids. The applicability of serum levels of calprotectin and ANGPTL8 for monitoring of the activity of psoriasis (diagnostic markers) is also evaluated. Methods. Clinical examination (PASI score, MetS), enzyme-linked immunosorbent assay (ELISA), and Enzyme Immunoassay (EIA). Serum calprotectin, ANGPTL8, 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine. Results and Conclusions. The psoriasis significantly increased the serum level of calprotectin and the serum level of oxidative damage to nucleic acids, however not the serum level of ANGPTL8. The presence of MetS did not significantly affect the serum levels of calprotectin, ANGPTL8, and oxidative damage to nucleic acids in either psoriasis patients or controls. It seems that the serum level of calprotectin (but not the serum level of ANGPTL8) could be used as a biomarker for monitoring the activity of psoriasis.

Highlights from the Faraday discussion on photoinduced processes in nucleic acids and proteins

2018 ◽  
Vol 54 (34) ◽  
pp. 4207-4215 ◽  
Author(s):  
Javier Segarra-Martí ◽  
Remya Ramakrishnan ◽  
Javier Vinals ◽  
Ashley J. Hughes
Keyword(s):  
Nucleic Acids ◽  
Royal Society ◽  
Photoinduced Processes

The Faraday meeting on photoinduced processes in nucleic acids and proteins was held in Thiruvananthapuram, India in January 2018, continuing the meetings initiated by the Royal Society over 110 years ago, with the first meeting taking place in London in 1907.

Pro-poor Growth and Policies: The Asian Experience (The Quaid-i-Azam Memorial Lecture)

2003 ◽  
Vol 42 (4I) ◽  
pp. 313-348
Author(s):  
Hafiz A. Carstens ◽  
T. Palanivel
Keyword(s):  
Poverty Reduction ◽  
Agricultural Development ◽  
Public Investment ◽  
Memorial Lecture ◽  
Asian Countries ◽  
Poor Growth ◽  
Strong Positive Relationship ◽  
Inflation Rates ◽  
Macroeconomic Determinants ◽  
The Impact

The objective of this paper is to assemble on a systematic basis the available data on Asian countries and then analyse the relationship between growth and poverty reduction in a long-term perspective, as well as the impact of different macroeconomic variables on the intensity of this relationship. The results indicate that there is not only a strong positive relationship between growth and poverty reduction, but also that this relationship is highly variable across countries and time periods. The key macroeconomic determinants of the degree of pro-poor growth appear to be the rates of employment and agricultural growth. Inflation, at least up to a certain rate, does not impact poverty negatively, while the role of exports is essentially indirect through the contribution to the overall rate of economic growth. Examination of the change in policy stance of the Asian countries during the 1990s in relation to the 1980s demonstrates that on balance the mix of policies has not been pro-poor. The apparent sacrifice of growth in pursuit of macroeconomic stability has diminished the impact on poverty reduction. Given the relatively weak trade-off between inflation and growth with regard to the impact on poverty and the fact that inflation rates are currently low in the region, it is argued that countries can be more flexible in their policy stance with regard to the adoption of more growth-oriented as opposed to stabilisation policies. In particular, a case is made for resorting to a more expansionary counter-cyclical fiscal policy, led by higher levels of public investment, supported by appropriate monetary and exchange rate policies. The paper concludes with a detailed description of the policies designed to achieve faster agricultural development and greater employment generation.

scholarly journals Frederick Sanger CBE CH OM. 13 August 1918 — 19 November 2013

2015 ◽  
Vol 61 ◽  
pp. 437-466 ◽  
Author(s):  
George G. Brownlee
Keyword(s):  
Nucleic Acids ◽  
Genetic Code ◽  
Protein Sequencing ◽  
Academic Life ◽  
Protein Chemistry ◽  
Overlapping Genes ◽  
Sequence Structure ◽  
Sequencing Method ◽  
And Function ◽  
The Impact

Frederick Sanger—always known as Fred—was one of the most influential scientists of the twentieth century. A committed molecular biologist, he spent all his academic life in Cambridge devising methods for sequencing proteins and nucleic acids. He twice won the Nobel Prize in Chemistry—once in 1958 for protein sequencing and then again in 1980 for sequencing nucleic acids. He is the only scientist to have achieved this distinction. The impact of his work was enormous. He opened up the field of protein chemistry in the 1950s, stimulating studies of the sequence, structure and function of many proteins and enzymes. In 1977 he devised an ingenious DNA sequencing method that has revolutionized molecular biology and made it possible to completely sequence the 3 × 10 9 nucleotides of the human genome. Moreover, he confirmed the genetic code, showed that the genetic code differed in mitochondria, and discovered overlapping genes. Fred Sanger was a modest, reserved man but to his colleagues and friends he always had vision. He was a pioneer and a leader.

Nucleic Acids and Molecular Tools

2011 ◽  
Author(s):  
Thomas S. Bianchi ◽  
Elizabeth A. Canuel
Keyword(s):  
Nucleic Acids ◽  
Organic Geochemistry ◽  
Molecular Genetic ◽  
Molecular Ecology ◽  
Genetic Data ◽  
Nitrogen And Phosphorus ◽  
Isotopic Signatures ◽  
Molecular Genetic Data ◽  
The Impact ◽  
Rna And Dna

This chapter examines nucleic acids, polymers of RNA and DNA, which act as the templates for protein synthesis. High levels of nucleic acids in microbes contribute to their elevated nitrogen and phosphorus contents. In recent years, isotopic signatures of nucleic acids have provided new insights about the sources of carbon-supporting bacterial activity. The chapter discusses recent efforts to bridge the fields of organic geochemistry and molecular ecology. The coupling of biomarker information to molecular (genetic) data has the potential to provide new insights about specific sediment microbial communities and their effects on sediment organic matter. Recent studies have provided information about the evolutionary basis of biosynthetic pathways, which influence the capabilities of microorganisms to utilize specific substrates and the synthesis of unique biomarkers. Such efforts demonstrate the impact that microorganisms have on organic geochemistry.

Sign in / Sign up

Export Citation Format

Share Document