Nanoparticle-induced structural changes in lung surfactant membranes: an X-ray scattering study

2018 ◽  
Vol 5 (5) ◽  
pp. 1218-1230 ◽  
Author(s):  
Shirin Behyan ◽  
Olga Borozenko ◽  
Abdullah Khan ◽  
Manon Faral ◽  
Antonella Badia ◽  
...  

Low concentrations of cationic silica nanoparticles impact lung surfactant membrane structure while anionic nanoparticles have minimal effect.

1989 ◽  
Vol 40 ◽  
pp. 1-8 ◽  
Author(s):  
Dimas R. Vollet ◽  
José C. Moreira ◽  
Lauro T. Kubota ◽  
José A. Varela ◽  
Yoshitaka Gushikem

2005 ◽  
Vol 38 (14) ◽  
pp. 6099-6105 ◽  
Author(s):  
Günther A. Maier ◽  
Gernot Wallner ◽  
Reinhold W. Lang ◽  
Peter Fratzl

Author(s):  
Eva-Maria Mandelkow ◽  
Eckhard Mandelkow ◽  
Joan Bordas

When a solution of microtubule protein is changed from non-polymerising to polymerising conditions (e.g. by temperature jump or mixing with GTP) there is a series of structural transitions preceding microtubule growth. These have been detected by time-resolved X-ray scattering using synchrotron radiation, and they may be classified into pre-nucleation and nucleation events. X-ray patterns are good indicators for the average behavior of the particles in solution, but they are difficult to interpret unless additional information on their structure is available. We therefore studied the assembly process by electron microscopy under conditions approaching those of the X-ray experiment. There are two difficulties in the EM approach: One is that the particles important for assembly are usually small and not very regular and therefore tend to be overlooked. Secondly EM specimens require low concentrations which favor disassembly of the particles one wants to observe since there is a dynamic equilibrium between polymers and subunits.


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