Emerging investigator series: oxidative potential of diesel exhaust particles: role of fuel, engine load, and emissions control

2019 ◽  
Vol 21 (5) ◽  
pp. 819-830 ◽  
Author(s):  
Naman Sharma ◽  
Cody Vanderheyden ◽  
Kevin Klunder ◽  
Charles S. Henry ◽  
John Volckens ◽  
...  
Keyword(s):  
Control System ◽  
Diesel Exhaust ◽  
Elemental Carbon ◽  
Diesel Exhaust Particles ◽  
Emissions Control ◽  
Oxidative Potential ◽  
Engine Load ◽  
Exhaust Particles

Biodiesel and the use of an emissions control system significantly reduced the oxidative potential of diesel exhaust particles, which correlated with reduction in emissions of elemental carbon.

Role of diesel exhaust particles in the induction of allergic asthma to low doses of soybean

2020 ◽  
pp. 110337
Author(s):  
M. de Homdedeu ◽  
M.J. Cruz ◽  
S. Sánchez-Díez ◽  
S. Gómez-Ollés ◽  
I. Ojanguren ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Low Doses ◽  
Exhaust Particles

scholarly journals Cellular Basis of the Role of Diesel Exhaust Particles in Inducing Th2-Dominant Response

2005 ◽  
Vol 174 (4) ◽  
pp. 2412-2419 ◽  
Author(s):  
Tomoyuki Ohtani ◽  
Satoshi Nakagawa ◽  
Masahiro Kurosawa ◽  
Masato Mizuashi ◽  
Maki Ozawa ◽  
...  
Keyword(s):  
Diesel Exhaust ◽  
Diesel Exhaust Particles ◽  
Dominant Response ◽  
Cellular Basis ◽  
Exhaust Particles

The role of iron in reactive oxygen species generation from diesel exhaust particles

2006 ◽  
Vol 20 (6) ◽  
pp. 851-857 ◽  
Author(s):  
Sungjo Park ◽  
Haeyun Nam ◽  
Namhyun Chung ◽  
Jung-Duck Park ◽  
Young Lim
Keyword(s):  
Reactive Oxygen Species ◽  
Diesel Exhaust ◽  
Reactive Oxygen Species Generation ◽  
Reactive Oxygen ◽  
Diesel Exhaust Particles ◽  
Oxygen Species ◽  
Exhaust Particles

Effects of diesel exhaust particles on macrophage polarization

2016 ◽  
Vol 36 (4) ◽  
pp. 412-420 ◽  
Author(s):  
N Labranche ◽  
C El Khattabi ◽  
G Berkenboom ◽  
S Pochet
Keyword(s):  
Mrna Expression ◽  
Diesel Exhaust ◽  
Macrophage Polarization ◽  
Critical Role ◽  
Diesel Exhaust Particles ◽  
Western Blots ◽  
Cardiovascular Morbidity And Mortality ◽  
Tnf Α ◽  
Exhaust Particles

Background: Exposure to diesel exhaust particles (DEP) has long been associated with increased cardiovascular morbidity and mortality. The development of DEP toxicity seems to be linked to inflammation in which macrophages play a critical role. Macrophages can be polarized into proinflammatory M1 or anti-inflammatory M2 macrophages. The aim of this study was to identify the role of inflammation in DEP-induced toxicity by assessing the effects of DEP on macrophage polarization. Methods: Monocyte-derived macrophages (Mϕ) were stimulated with interferon γ and lipopolysaccharide or interleukin (IL)-4 to obtain M1 and M2 subtypes, respectively. To test the polarization capacity of DEP, Mϕ cells were exposed to DEP and compared to Mϕ, M1, and M2. We also studied the effects of DEP on already-polarized M1 or M2. The M1 markers assessed were tumor necrosis factor α (TNF-α) and IL-1β, while the M2 markers were the mannose receptor C type 1 (MRC-1) and transglutaminase 2 (TGM2). Results: Western blots revealed a 31 kDa band corresponding to pro-IL-1β, but only in M1-polarized macrophages. In M1, we also observed an upregulation of TNF-α messenger RNA (mRNA) expression. MRC-1 and TGM2 mRNA expression were only significantly enhanced in M2. DEP had no effect on any of the M1/M2 markers assessed. Moreover, DEP were not able to modify the phenotype of already-polarized M1 or M2. Conclusion: Mϕ incubation with DEP did not have any effect on macrophage polarization, at least on the markers assessed in this study, namely, TNF-α/IL-1β for M1, and MRC-1/TGM2 for M2. Hence, these data argue against an important role of inflammation in DEP-induced vascular toxicity.

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