scholarly journals Push and pull: the potential role of boron in N2 activation

2018 ◽  
Vol 47 (31) ◽  
pp. 10377-10381 ◽  
Author(s):  
Adam J. Ruddy ◽  
Darren M. C. Ould ◽  
Paul D. Newman ◽  
Rebecca L. Melen
Keyword(s):  
Potential Role ◽  
Main Group ◽  
Main Group Chemistry ◽  
Recent Developments ◽  
Push And Pull ◽  
N2 Activation

Recent developments in main group chemistry towards the activation and conversion of N2 have lead to the revelation that boron can greatly affect these processes.

Phosphorus Lewis acids: emerging reactivity and applications in catalysis

2016 ◽  
Vol 45 (4) ◽  
pp. 765-774 ◽  
Author(s):  
J. M. Bayne ◽  
D. W. Stephan
Keyword(s):  
Lewis Acids ◽  
Main Group ◽  
Focus Attention ◽  
Main Group Chemistry

Part of the renaissance in main group chemistry has been a result of the focus on reactivity and catalysis. In this tutorial review, we focus attention on the role of phosphorus-based Lewis acids in such advances.

scholarly journals Pathology of Gastrointestinal Stromal Tumors

2012 ◽  
Vol 5 ◽  
pp. CPath.S9689 ◽  
Author(s):  
Wai Chin Foo ◽  
Bernadette Liegl-Atzwanger ◽  
Alexander J. Lazar
Keyword(s):  
Potential Role ◽  
Soft Tissue Tumor ◽  
Kinase Inhibitors ◽  
Immunohistochemical Detection ◽  
Stromal Tumors ◽  
Activating Mutations ◽  
Receptor Kinases ◽  
Recent Developments ◽  
Immunohistochemical Diagnosis

Gastrointestinal stromal tumor (GIST) is a well recognized and relatively well understood soft tissue tumor. Early events in GIST development are activating mutations in KIT or PDGFRA, which occur in most GISTs and encode for mutated tyrosine receptor kinases that are therapeutic targets for tyrosine kinase inhibitors, including imatinib and sunitinib. A small minority of GISTs possessing neither KIT nor PDGFRA mutations may have germline mutations in SDH, suggesting a potential role of SDH in the pathogenesis. Immunohistochemical detection of KIT, and more recently DOG1, has proven to be reliable and useful in the diagnosis of GISTs. Because current and future therapies depend on pathologists, it is important that they recognize KIT-negative GISTs, GISTs in specific clinical contexts, GISTs with unusual morphology, and GISTs after treatment. This review focuses on recent developments in the understanding of the biology, immunohistochemical diagnosis, the role of molecular analysis, and risk assessment of GISTs.

How do histone modifications contribute to transgenerational epigenetic inheritance in C. elegans?

2020 ◽  
Vol 48 (3) ◽  
pp. 1019-1034 ◽  
Author(s):  
Rachel M. Woodhouse ◽  
Alyson Ashe
Keyword(s):  
Histone Modifications ◽  
Molecular Mechanisms ◽  
Epigenetic Inheritance ◽  
Nematode Caenorhabditis Elegans ◽  
Histone Methyltransferases ◽  
Transgenerational Epigenetic Inheritance ◽  
C Elegans ◽  
Recent Developments ◽  
Gene Regulatory

Gene regulatory information can be inherited between generations in a phenomenon termed transgenerational epigenetic inheritance (TEI). While examples of TEI in many animals accumulate, the nematode Caenorhabditis elegans has proven particularly useful in investigating the underlying molecular mechanisms of this phenomenon. In C. elegans and other animals, the modification of histone proteins has emerged as a potential carrier and effector of transgenerational epigenetic information. In this review, we explore the contribution of histone modifications to TEI in C. elegans. We describe the role of repressive histone marks, histone methyltransferases, and associated chromatin factors in heritable gene silencing, and discuss recent developments and unanswered questions in how these factors integrate with other known TEI mechanisms. We also review the transgenerational effects of the manipulation of histone modifications on germline health and longevity.

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