scholarly journals Delocalized hole transport coupled to sub-ns tryptophanyl deprotonation promotes photoreduction of class II photolyases

2018 ◽  
Vol 20 (39) ◽  
pp. 25446-25457 ◽  
Author(s):  
Fabien Lacombat ◽  
Agathe Espagne ◽  
Nadia Dozova ◽  
Pascal Plaza ◽  
Elisabeth Ignatz ◽  
...  
Keyword(s):  
Class Ii ◽  
Hole Transport ◽  
Tyrosine Oxidation

Ultrafast photoreduction of class II photolyases: the delocalized oxidation hole precedes distal tryptophanyl deprotonation and tyrosine oxidation.

Electron microscopy analysis of degenerating pancreatic ß cells in transgenic mice expressing the MHC Class I antigen Dd

1990 ◽  
Vol 48 (3) ◽  
pp. 548-549
Author(s):  
T. A. Stewart ◽  
D. Liggitt ◽  
S. Pitts ◽  
L. Martin ◽  
M. Siegel ◽  
...  
Keyword(s):  
Type I Diabetes ◽  
Disease Process ◽  
Class Ii ◽  
Class I ◽  
Type I ◽  
Aberrant Expression ◽  
Mhc Molecules ◽  
Endogenous Insulin ◽  
Class Ii Mhc ◽  
Ifn Γ

Insulin-dependant (Type I) diabetes mellitus (IDDM) is a metabolic disorder resulting from the lack of endogenous insulin secretion. The disease is thought to result from the autoimmune mediated destruction of the insulin producing ß cells within the islets of Langerhans. The disease process is probably triggered by environmental agents, e.g. virus or chemical toxins on a background of genetic susceptibility associated with particular alleles within the major histocompatiblity complex (MHC). The relation between IDDM and the MHC locus has been reinforced by the demonstration of both class I and class II MHC proteins on the surface of ß cells from newly diagnosed patients as well as mounting evidence that IDDM has an autoimmune pathogenesis. In 1984, a series of observations were used to advance a hypothesis, in which it was suggested that aberrant expression of class II MHC molecules, perhaps induced by gamma-interferon (IFN γ) could present self antigens and initiate an autoimmune disease. We have tested some aspects of this model and demonstrated that expression of IFN γ by pancreatic ß cells can initiate an inflammatory destruction of both the islets and pancreas and does lead to IDDM.

Mice with MHC class II− B cells

1997 ◽  
Vol 56 (1-3) ◽  
pp. 203 ◽  
Author(s):  
G Williams
Keyword(s):  
B Cells ◽  
Mhc Class Ii ◽  
Class Ii
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