scholarly journals Temperature dependence of dynamic, tunnelling and kinetic isotope effects in formate dehydrogenase

2018 ◽  
Vol 20 (40) ◽  
pp. 25722-25737 ◽  
Author(s):  
Maite Roca ◽  
J. Javier Ruiz-Pernía ◽  
Raquel Castillo ◽  
Mónica Oliva ◽  
Vicent Moliner
Keyword(s):  
Temperature Dependence ◽  
Chemical Reaction ◽  
Formate Dehydrogenase ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Chemical System ◽  
Kinetic Isotope

The protein cannot be considered as a passive spectator of the chemical system; it is part of the chemical reaction.

scholarly journals Oscillatory Active-Site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase

ACS Catalysis ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 11199-11206 ◽  
Author(s):  
Philip Pagano ◽  
Qi Guo ◽  
Chethya Ranasinghe ◽  
Evan Schroeder ◽  
Kevin Robben ◽  
...  
Keyword(s):  
Active Site ◽  
Formate Dehydrogenase ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope

DEUTERIUM KINETIC ISOTOPE EFFECTS: V TEMPERATURE DEPENDENCE OF β-DEUTERIUM EFFECTS IN WATER SOLVOLYSIS OF ISOPROPYL COMPOUNDS

1961 ◽  
Vol 39 (10) ◽  
pp. 1989-1994 ◽  
Author(s):  
K. T. Leffek ◽  
R. E. Robertson ◽  
S. E. Sugamori
Keyword(s):  
Temperature Dependence ◽  
Isotope Effect ◽  
Isotope Effects ◽  
Zero Point ◽  
Kinetic Isotope Effects ◽  
Methyl Groups ◽  
Deuterium Isotope Effect ◽  
Point Energy ◽  
Kinetic Isotope ◽  
Enthalpy Of Activation

The secondary β-deuterium isotope effect (kH/kD) has been measured over a range of temperature for the water solvolysis reactions of isopropyl methanesulphonate, p-toluenesulphonate, and bromide. In these cases the isotope effect is due to a difference in entropies of activation of the isotopic analogues rather than a difference in the enthalpies of activation. It is suggested that the observed isotope effect is due to internal rotational effects of the methyl groups in the isopropyl radical, and the lack of an isotope effect on the enthalpy of activation is accounted for by a cancellation of an effect from this source and one from zero-point energy.

Temperature Dependence and Deuterium Kinetic Isotope Effects in the CH (CD) + C2H4(C2D4) Reaction between 295 and 726 K

2001 ◽  
Vol 105 (22) ◽  
pp. 5393-5401 ◽  
Author(s):  
Holger Thiesemann ◽  
Eileen P. Clifford ◽  
Craig A. Taatjes ◽  
Stephen J. Klippenstein
Keyword(s):  
Temperature Dependence ◽  
Isotope Effects ◽  
Kinetic Isotope Effects ◽  
Kinetic Isotope
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