scholarly journals Conformational investigation of the structure–activity relationship of GdFFD and its analogues on an achatin-like neuropeptide receptor of Aplysia californica involved in the feeding circuit

2018 ◽  
Vol 20 (34) ◽  
pp. 22047-22057 ◽  
Author(s):  
Thanh D. Do ◽  
James W. Checco ◽  
Michael Tro ◽  
Joan-Emma Shea ◽  
Michael T. Bowers ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Computational Modeling ◽  
Ion Mobility ◽  
Aplysia Californica ◽  
Ion Mobility Mass Spectrometry ◽  
Cognate Receptor ◽  
Structure Activity ◽  
Conformational Investigation ◽  
Relationship Of

Computational modeling and ion-mobility mass spectrometry are used to understand and predict the activity of endogenous d-amino acid-containing neuropeptides at their cognate receptor.

scholarly journals Fast and Effective Ion Mobility–Mass Spectrometry Separation ofd-Amino-Acid-Containing Peptides

2017 ◽  
Vol 89 (21) ◽  
pp. 11787-11794 ◽  
Author(s):  
Kevin Jeanne Dit Fouque ◽  
Alyssa Garabedian ◽  
Jacob Porter ◽  
Matthew Baird ◽  
Xueqin Pang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Amino Acid ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry

Rapid Diagnosis of Parkinson’s Disease from Sebum using Paper Spray Ionisation Ion Mobility Mass Spectrometry

2020 ◽  
Author(s):  
Depanjan Sarkar ◽  
Drupad Trivedi ◽  
Eleanor Sinclair ◽  
Sze Hway Lim ◽  
Caitlin Walton-Doyle ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ion Mobility ◽  
Neurodegenerative Disorder ◽  
Treatment Options ◽  
Ion Mobility Mass Spectrometry ◽  
Paper Spray ◽  
Molecular Features ◽  
Validation Set

Parkinson’s disease (PD) is the second most common neurodegenerative disorder for which identification of robust biomarkers to complement clinical PD diagnosis would accelerate treatment options and help to stratify disease progression. Here we demonstrate the use of paper spray ionisation coupled with ion mobility mass spectrometry (PSI IM-MS) to determine diagnostic molecular features of PD in sebum. PSI IM-MS was performed directly from skin swabs, collected from 34 people with PD and 30 matched control subjects as a training set and a further 91 samples from 5 different collection sites as a validation set. PSI IM-MS elucidates ~ 4200 features from each individual and we report two classes of lipids (namely phosphatidylcholine and cardiolipin) that differ significantly in the sebum of people with PD. Putative metabolite annotations are obtained using tandem mass spectrometry experiments combined with accurate mass measurements. Sample preparation and PSI IM-MS analysis and diagnosis can be performed ~5 minutes per sample offering a new route to for rapid and inexpensive confirmatory diagnosis of this disease.

P‐97: Separation of Isomeric OLED Materials Using Ion Mobility‐Mass Spectrometry (IM‐MS)

2021 ◽  
Vol 52 (1) ◽  
pp. 1444-1447
Author(s):  
Hirotaka Shioji ◽  
Azusa Uematsu ◽  
Motoshi Onoda ◽  
Keiko Matsuda ◽  
Keisuke Sawada ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Ion Mobility ◽  
Ion Mobility Mass Spectrometry
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