Structural and photodynamic properties of the anti-cancer drug irinotecan in aqueous solutions of different pHs

2018 ◽  
Vol 20 (20) ◽  
pp. 14182-14191 ◽  
Author(s):  
Maria Rosaria di Nunzio ◽  
Yasmin Douhal ◽  
Juan Angel Organero ◽  
Abderrazzak Douhal
Keyword(s):  
Aqueous Solutions ◽  
Cancer Drug ◽  
Water Solutions ◽  
Anti Cancer ◽  
Influence Of Ph

The influence of pH on the structures and dynamics of irinotecan (a potent anti-cancer drug) in water solutions was elucidated.

A 195Pt and 15N N.M.R. study of the anticancer drug, cis-diammine-dichloroplatinum(II), and its hydrolysis and oligomerization products

1981 ◽  
Vol 34 (3) ◽  
pp. 659 ◽  
Author(s):  
CJ Boreham ◽  
JA Broomhead ◽  
DP Fairlie
Keyword(s):  
Sodium Chloride ◽  
Aqueous Solutions ◽  
Anticancer Drug ◽  
Cancer Drug ◽  
Anti Cancer

195Pt and 15N n.m.r, spectra for aqueous solutions of the anti-cancer drug cis-diamminedichloroplatinum(II) and its hydrolysis and oligomerization products are reported. In the blood substituteHanks medium, conversion of cis-[Pt(15NH3)2(H20)2](NO3)2 into cis[PtCl2(15NH3)2], cis-[PtCl(H20)(15NH3)2]+,[Pt(15NH3)2OH]33+ and [Pt(15NH3)2OH]22+ has been observed, the reaction taking several hours at 30�C. In 0.15 M sodium chloride, both [Pt(NH3)2OH]33+ and[Pt(NH3)2OH]22+ are converted overnight into cis-[PtCl(H2O)(NH3)2]+. The infrared bands at 546 and 522 cm-1 in [Pt(NH3)2OH]2SO4 and at 520 cm-1 in [Pt(NH3)2OH]2(SO4)3 have been reassigned to Pt-N modes.

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Psychogenic Mass Syndrome in Anti-Cancer Drug Exposure

2010 ◽  
Author(s):  
N. Magnavita ◽  
I. lavicoli ◽  
V. Leso ◽  
A. Bergamaschi
Keyword(s):  
Drug Exposure ◽  
Cancer Drug ◽  
Anti Cancer

Nanocomposites: - A Recent Overview

2020 ◽  
pp. 9-21
Author(s):  
Pavan C ◽  
Madhavi BLR
Keyword(s):  
Targeted Drug Delivery ◽  
Current Trend ◽  
Nanocomposite Films ◽  
Cancer Drug ◽  
Preparation Methods ◽  
Standard Material ◽  
Global Issues ◽  
Sustainable Solutions ◽  
Anti Cancer ◽  
Treatment And Diagnosis

Nanocomposites are substances that incorporate nanoparticles (0.5-5% by weight) into a matrix of standard material, which enhances the mechanical strength, toughness including thermal or electrical conductivity and other properties. Nanocomposites are versatile in terms of their applications such as anti-corrosive, healing of bones, sensors, environmental protection, packaging, wastewater treatment, and diagnosis of tumors and other diverse uses. They may be fabricated by blending nanofillers with a polymer to produce a composite. The current trend of processing is by polymerizing monomers. Nanocomposites serve as sustainable solutions to curb global issues. Evaluation is performed on properties such as mechanical, thermal, dispersion, and toxicological. Some marketed products of nanocomposites include In Mat (coating), FiltekZ350 XT by 3M (tooth fillers), chitosan/organic rectorite nanocomposite films (bactericidal activity), graphene oxide/Carboxymethylcellulose (targeted drug delivery of anti-cancer drug doxorubicin), MD1 Flex, Nano Clean MD1, Plactive TM (Antimicrobial nanocomposites) and NovaProTM(Tooth fillers). This article discusses about Nanocomposites–their types, preparation methods, recent research and applications.

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