scholarly journals Guest–host interactions of nanoconfined anti-cancer drug in metal–organic framework exposed by terahertz dynamics

2019 ◽  
Vol 55 (27) ◽  
pp. 3868-3871 ◽  
Author(s):  
Barbara E. Souza ◽  
Svemir Rudić ◽  
Kirill Titov ◽  
Arun S. Babal ◽  
James D. Taylor ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Inelastic Neutron Scattering ◽  
Metal Organic Framework ◽  
Inelastic Neutron ◽  
Cancer Drug ◽  
Host Interactions ◽  
Composite Systems ◽  
Anti Cancer ◽  
Metal Organic ◽  
Organic Framework

Guest–host interactions of mechanochemically synthesized drug@MOF composite systems revealed by inelastic neutron scattering.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

Investigating H2Sorption in a Fluorinated Metal–Organic Framework with Small Pores Through Molecular Simulation and Inelastic Neutron Scattering

Langmuir ◽  
2015 ◽  
Vol 31 (26) ◽  
pp. 7328-7336 ◽  
Author(s):  
Katherine A. Forrest ◽  
Tony Pham ◽  
Peter A. Georgiev ◽  
Florian Pinzan ◽  
Christian R. Cioce ◽  
...  
Keyword(s):  
Neutron Scattering ◽  
Molecular Simulation ◽  
Inelastic Neutron Scattering ◽  
Metal Organic Framework ◽  
Inelastic Neutron ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Investigation of Ionic Liquid interaction with ZnBDC-Metal Organic Framework through Scanning EXAFS and Inelastic Neutron Scattering

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Rituraj Dutta ◽  
Mala N. Rao ◽  
Ashok Kumar
Keyword(s):  
Ionic Liquid ◽  
Neutron Scattering ◽  
Inelastic Neutron Scattering ◽  
Metal Organic Framework ◽  
Inelastic Neutron ◽  
Binding Energies ◽  
Coordination Geometry ◽  
Xps Spectra ◽  
Metal Organic ◽  
Organic Framework

Abstract Zn based Metal-Organic Framework (MOF), Zinc 1,4-benzenedicarboxylate (ZnBDC) has been synthesized and incorporated with ionic liquid (IL) 1-butyl-3 methylimidazolium bromide (BMIMBr) at optimum 50 wt% of IL. Interaction of BMIMBr in the micropores of ZnBDC-MOF is investigated by XPS, scanning EXAFS and inelastic neutron spectroscopy. Significant increase in binding energies of Zn spin-orbit peaks upon IL incorporation is observed from XPS spectra indicating motion of Br− anions of the IL BMIMBr towards the unsaturated Zn cluster of ZnBDC-MOF. The k-space periodicity as well as the local coordination geometry of Zn K-edge is investigated from the scanning EXAFS and XANES spectra. Asymmetric oscillation periodicity has been observed from the k-space scanning XANES spectra upon IL incorporation. Difference in peak positions of oxygen and zinc are observed from the R-space scanning EXAFS spectra suggesting change in coordination geometry due to dehydration of Zn2+ ion in the ZnBDC-MOF upon IL incorporation. Incorporation of IL in the pores of ZnBDC-MOF gives rise to increased scattering intensity in the Inelastic Neutron Scattering (INS) spectra, which is attributed to the displacement of IL ions in the MOF pores.

scholarly journals Mechanochemical Approaches Towards the in Situ Confinement of 5-FU Anti-Cancer Drug Within MIL-100 (Fe) Metal-Organic Framework

2020 ◽  
Author(s):  
Barbara Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Release ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
One Pot ◽  
Host Interactions ◽  
Anti Cancer ◽  
Metal Organic ◽  
Iron Based ◽  
Organic Framework

We report two solvent-free mechanochemical methods to achieve one‑pot encapsulation of anti-cancer drug 5‑Fluorouracil (5‑FU) in the iron-based MIL‑100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL‑100 systems derived from <i>in situ </i>manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.

Targeted VEGF-triggered release of an anti-cancer drug from aptamer-functionalized metal–organic framework nanoparticles

Nanoscale ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 4650-4657 ◽  
Author(s):  
Wei-Hai Chen ◽  
Sohn Yang Sung ◽  
Michael Fadeev ◽  
Alessandro Cecconello ◽  
Rachel Nechushtai ◽  
...  
Keyword(s):  
Metal Organic Framework ◽  
Cancer Drug ◽  
Triggered Release ◽  
Anti Cancer ◽  
Metal Organic ◽  
Targeted Release ◽  
Organic Framework

Drug-loaded DNA-capped metal–organic framework nanoparticles are unlocked by the VEGF biomarker, resulting in the targeted release of the drug.

scholarly journals Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal–organic framework

CrystEngComm ◽  
2020 ◽  
Vol 22 (27) ◽  
pp. 4526-4530
Author(s):  
Barbara E. Souza ◽  
Jin-Chong Tan
Keyword(s):  
Drug Delivery Systems ◽  
Low Cost ◽  
Metal Organic Framework ◽  
Cancer Drug ◽  
Drug Molecules ◽  
Anti Cancer ◽  
Metal Organic ◽  
Host Metal ◽  
Organic Framework

Low-cost mechanochemistry methods for in situ confinement of “guest” drug molecules into a “host” metal–organic framework to yield nanoscale guest@host drug delivery systems.

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