Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides

2019 ◽  
Vol 55 (48) ◽  
pp. 6850-6853 ◽  
Author(s):  
Takenori Shimo ◽  
Keisuke Tachibana ◽  
Yuki Kawawaki ◽  
Yuuka Watahiki ◽  
Taku Ishigaki ◽  
...  
Keyword(s):  
Secondary Structure ◽  
Structure Formation ◽  
Exon Skipping ◽  
Secondary Structure Content ◽  
Secondary Structure Formation

LNA-based splice-switching oligonucleotides containing 7-deaza-2′-deoxyguanosine or 2′-deoxyinosine avoid secondary structure formation and showed higher exon skipping activities.

scholarly journals Alternative DNA secondary structure formation affects RNA polymerase II promoter-proximal pausing in human

2018 ◽  
Vol 19 (1) ◽  
Author(s):  
Karol Szlachta ◽  
Ryan G. Thys ◽  
Naomi D. Atkin ◽  
Levi C. T. Pierce ◽  
Stefan Bekiranov ◽  
...  
Keyword(s):  
Secondary Structure ◽  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Structure Formation ◽  
Dna Secondary Structure ◽  
Secondary Structure Formation
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