B(C6F5)3-Catalyzed redox-neutral β-alkylation of tertiary amines using p-quinone methides via borrowing hydrogen

2019 ◽  
Vol 55 (9) ◽  
pp. 1217-1220 ◽  
Author(s):  
Rui Li ◽  
Yong Chen ◽  
Kun Jiang ◽  
Feiyi Wang ◽  
Cuifen Lu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Tertiary Amines ◽  
Quinone Methides ◽  
Metal Free ◽  
Borrowing Hydrogen

A transition metal-free intermolecular redox-neutral β-alkylation of acyclic tertiary amines via borrowing hydrogen catalyzed by commercially available B(C6F5)3 was achieved.

Pyridine mediated transition-metal-free direct alkylation of anilines using alcohols via borrowing hydrogen conditions

2020 ◽  
Vol 56 (88) ◽  
pp. 13607-13610 ◽  
Author(s):  
Rajagopal Pothikumar ◽  
Venugopal T Bhat ◽  
Kayambu Namitharan
Keyword(s):  
Transition Metal ◽  
Traditional Approach ◽  
Metal Catalyst ◽  
Transition Metal Catalyst ◽  
Metal Free ◽  
Borrowing Hydrogen ◽  
Activation Of Alcohols ◽  
Catalyst Systems ◽  
Hydrogen Reactions

Herein, we report aza-aromatics based organic mediators as a readily accessible alternative to the traditional approach of using transition metal catalyst systems for the activation of alcohols in borrowing hydrogen reactions.

Direct Propargylation of ortho-Quinone Methides with Alkynyl Zinc Reagents: An Application to the One-Pot Synthesis of 2,3-Disubstituted Benzofurans

Synlett ◽  
2020 ◽  
Vol 31 (08) ◽  
pp. 818-822
Author(s):  
Hongjun Ren ◽  
Manman Sun ◽  
Jinyu Song ◽  
Lei Wang ◽  
Wenguang Yin ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Quinone Methides ◽  
One Pot ◽  
Metal Free ◽  
Efficient Strategy ◽  
One Pot Synthesis ◽  
Subsequent Cyclization ◽  
The One

A transition-metal-free propargylation of ortho-quinone methides (o-QMs) with alkynyl zinc reagents was achieved. A conjugate alkynylation of an o-QM and subsequent cyclization sequence in the presence of KOt-Bu for the synthesis of 2,3-disubstituted benzofurans in one pot was developed. This efficient strategy exhibits good functional-group compatibility and gives moderate to good yields. The present reaction might serve as an attractive method for the synthesis of polysubstituted benzofurans.

ChemInform Abstract: Employing Arynes in Transition-Metal-Free Monoarylation of Aromatic Tertiary Amines.

ChemInform ◽  
2014 ◽  
Vol 45 (13) ◽  
pp. no-no
Author(s):  
Sachin Suresh Bhojgude ◽  
Trinadh Kaicharla ◽  
Akkattu T. Biju
Keyword(s):  
Transition Metal ◽  
Tertiary Amines ◽  
Metal Free

Employing Arynes in Transition-Metal-Free Monoarylation of Aromatic Tertiary Amines

2013 ◽  
Vol 15 (21) ◽  
pp. 5452-5455 ◽  
Author(s):  
Sachin Suresh Bhojgude ◽  
Trinadh Kaicharla ◽  
Akkattu T. Biju
Keyword(s):  
Transition Metal ◽  
Tertiary Amines ◽  
Metal Free

α-C-H functionalizations of tertiary amines catalyzed/promoted by molecular iodine/derivatives

2021 ◽  
Author(s):  
Mohit L. Deb ◽  
B Shriya Saikia ◽  
Paran J. Borpatra ◽  
Pranjal K. Baruah
Keyword(s):  
Transition Metal ◽  
Molecular Iodine ◽  
Review Article ◽  
Tertiary Amines ◽  
Metal Free ◽  
Organic Syntheses

This review article focuses on the functionalization of α-C-H bond of tertiary amines via C-H activation catalyzed by iodine or its derivatives. Recently, transition metal-free C-H functionalizations in organic syntheses...

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