scholarly journals Synthesis and nitric oxide releasing properties of novel fluoroS-nitrosothiols

2019 ◽  
Vol 55 (3) ◽  
pp. 401-404 ◽  
Author(s):  
Yang Zhou ◽  
Jinyi Tan ◽  
Yuping Dai ◽  
Yanmin Yu ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
No Donors ◽  
Nitric Oxide Releasing

A novel family fluoroS-nitrosothiols is developed as NO donors, to stoichiometrically release NO with the clean formation of corresponding disulfides.

Nitric oxide-releasing polymeric furoxan conjugates

2015 ◽  
Vol 6 (44) ◽  
pp. 7737-7748 ◽  
Author(s):  
Tengjiao Wang ◽  
André J. van der Vlies ◽  
Hiroshi Uyama ◽  
Urara Hasegawa
Keyword(s):  
Nitric Oxide ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
No Donors ◽  
Poly Ethylene ◽  
Nitric Oxide Releasing ◽  
End Group

Polymeric nitric oxide (NO) donors were prepared by the conjugation of the azide-containing furoxans and poly(ethylene glycol) having an alkyne end groupviathe copper-catalyzed Huisgen cycloaddition.

Nitric oxide-releasing molecules at the interface of inorganic chemistry and biology: a concise overview

2019 ◽  
Vol 39 (2) ◽  
pp. 91-112 ◽  
Author(s):  
Jan Mohammad Mir ◽  
Bashir Ahmad Malik ◽  
Ram Charitra Maurya
Keyword(s):  
Inorganic Chemistry ◽  
Nitric Oxide ◽  
Amino Acids ◽  
No Production ◽  
No Donors ◽  
Chemically Modified ◽  
Nitrosyl Complexes ◽  
Ability To Act ◽  
Nitric Oxide Releasing ◽  
Biological Milieu

AbstractThe useful aspects of nitric oxide (NO) are nowadays widely known. Due to the need for this molecule in the maintenance of homeostasis, NO-releasing compounds are tested every year to optimize its levels in a patient suffering from low NO production. This manuscript is an update of some important historical concerns about nitrosyl complexes having the ability to act as NO-releasing compounds under the influence of different chemically modified environments. At present, the search for efficient and less harmful NO-releasing molecules at desirable targets and concentrations has gained considerable momentum in nitrosyl chemistry. Iron, ruthenium, and manganese nitrosyls have been investigated elitely to disentangle their electronic transition (excitation) under visible light to act as NO donors without harming the healthy cells of a target. There is much evidence supporting the increase of NO lability if amino acids are used as complexing ligands, the design of a reduction center close to an NO grouping, and the development of porphyrin system-based nitrosyl complexes. From the overall survey, it may be concluded that the desirable properties of such scaffolds need to be evaluated further to complement the biological milieu.

Novel β-galactosidase-specific O2-glycosylated diazeniumdiolate probes

2010 ◽  
Vol 88 (9) ◽  
pp. 969-980 ◽  
Author(s):  
Barry J. Bedell ◽  
D. Scott Bohle ◽  
Zhijie Chua ◽  
Alexander Czerniewski ◽  
Alan C. Evans ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Membranes ◽  
Synthesis And Characterization ◽  
Imaging Agents ◽  
Mri Imaging ◽  
No Donors ◽  
Molecular Mri ◽  
Nitric Oxide Releasing

Three β-galactosidase-specific nitric-oxide-releasing diazeniumdiolate conjugated probes were prepared as a prelude to studies of new potential molecular MRI imaging agents. A glycosylated derivative, 2e, designed to be trafficked across cell membranes, was also prepared. We report, in detail, the synthesis and characterization of these probes. In addition, the release of diazeniumdiolate from the probes by β-galactosidase-catalyzed hydrolysis was used to estimate their efficacy as serum-stable, specific NO donors.

scholarly journals Nitric Oxide-Releasing Polymeric Materials for Antimicrobial Applications: A Review

Antioxidants ◽  
2019 ◽  
Vol 8 (11) ◽  
pp. 556 ◽  
Author(s):  
Fan Rong ◽  
Yizhang Tang ◽  
Tengjiao Wang ◽  
Tao Feng ◽  
Jiang Song ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Pathogenic Bacteria ◽  
Polymeric Materials ◽  
Natural Polymers ◽  
No Donor ◽  
No Donors ◽  
External Stimulation ◽  
Antimicrobial Materials ◽  
Nitric Oxide Releasing ◽  
Trigger Mechanisms

Polymeric materials releasing nitric oxide have attracted significant attention for therapeutic use in recent years. As one of the gaseous signaling agents in eukaryotic cells, endogenously generated nitric oxide (NO) is also capable of regulating the behavior of bacteria as well as biofilm formation in many metabolic pathways. To overcome the drawbacks caused by the radical nature of NO, synthetic or natural polymers bearing NO releasing moiety have been prepared as nano-sized materials, coatings, and hydrogels. To successfully design these materials, the amount of NO released within a certain duration, the targeted pathogens and the trigger mechanisms upon external stimulation with light, temperature, and chemicals should be taken into consideration. Meanwhile, NO donors like S-nitrosothiols (RSNOs) and N-diazeniumdiolates (NONOates) have been widely utilized for developing antimicrobial polymeric agents through polymer-NO donor conjugation or physical encapsulation. In addition, antimicrobial materials with visible light responsive NO donor are also reported as strong and physiological friendly tools for rapid bacterial clearance. This review highlights approaches to delivery NO from different types of polymeric materials for combating diseases caused by pathogenic bacteria, which hopefully can inspire researchers facing common challenges in the coming ‘post-antibiotic’ era.

Nitric Oxide-Releasing Biomaterials for Biomedical Applications

2016 ◽  
Vol 23 (24) ◽  
pp. 2579-2601 ◽  
Author(s):  
Xin Zhou ◽  
Jimin Zhang ◽  
Guowei Feng ◽  
Jie Shen ◽  
Deling Kong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biomedical Applications ◽  
Nitric Oxide Releasing

scholarly journals Doxycycline-Loaded Nitric Oxide-Releasing Nanomatrix Gel in Replanted Rat Molar on Pulp Regeneration

2021 ◽  
Vol 11 (13) ◽  
pp. 6041
Author(s):  
Kwan-Hee Yun ◽  
Mi-Ja Ko ◽  
Yong-Kown Chae ◽  
Koeun Lee ◽  
Ok-Hyung Nam ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Standard Deviation ◽  
Treatment Group ◽  
Root Surface ◽  
Lower Grade ◽  
Histomorphometric Analysis ◽  
Pulp Regeneration ◽  
Pulp Inflammation ◽  
Nitric Oxide Releasing ◽  
Rat Molar

The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treatment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard deviation) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

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