Stereogenic cis-2-substituted-N-acetyl-3-hydroxy-indolines via ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation

2018 ◽  
Vol 54 (96) ◽  
pp. 13503-13506 ◽  
Author(s):  
Zhonghua Luo ◽  
Guodong Sun ◽  
Zihong Zhou ◽  
Guozhu Liu ◽  
Baolei Luan ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
High Yields

Ruthenium(ii)-catalyzed dynamic kinetic resolution-asymmetric transfer hydrogenation of racemic 2-substituted-N-acetyl-3-oxoindolines is reported, affording cis-2-substituted-N-acetyl-3-hydroxyindolines in high yields with excellent diastereoselectivity and enantioselectivity.

Enantioselective synthesis of chiral multicyclic γ-lactones via dynamic kinetic resolution of racemic γ-keto carboxylic acids

2020 ◽  
Vol 7 (1) ◽  
pp. 104-108 ◽  
Author(s):  
Zhichao Xiong ◽  
Jiangyan Tian ◽  
Peng Xue ◽  
Xumu Zhang ◽  
Hui Lv
Keyword(s):  
Carboxylic Acids ◽  
Kinetic Resolution ◽  
Enantioselective Synthesis ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
High Yields

Ru-Catalyzed asymmetric transfer hydrogenation of γ-keto carboxylic acids has been achieved, affording chiral multicyclic γ-lactones in high yields with excellent diastereo- and enantioselectivities.

scholarly journals trans-Diastereoselective Ru(II)-Catalyzed Asymmetric Transfer Hydrogenation of α-Acetamido Benzocyclic Ketones via Dynamic Kinetic Resolution

2019 ◽  
Vol 21 (10) ◽  
pp. 3644-3648 ◽  
Author(s):  
Andrej Emanuel Cotman ◽  
Matic Lozinšek ◽  
Baifan Wang ◽  
Michel Stephan ◽  
Barbara Mohar
Keyword(s):  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution

A new cost-effective Ru-chloramphenicol base derivative catalyst for the asymmetric transfer hydrogenation/dynamic kinetic resolution of N-Boc α-amino-β-ketoesters and its application to the synthesis of the chiral core of vancomycin

RSC Advances ◽  
2016 ◽  
Vol 6 (44) ◽  
pp. 37701-37709 ◽  
Author(s):  
Xinlong Wang ◽  
Lingjun Xu ◽  
Fangjun Xiong ◽  
Yan Wu ◽  
Fener Chen
Keyword(s):  
Asymmetric Synthesis ◽  
Kinetic Resolution ◽  
Cost Effective ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution ◽  
Amino Esters ◽  
Base Derivative

Herein we describe the application of Ru-chloramphenicol base complexes catalyzed highly diastereo- and enantioselective transfer hydrogenation of N-Boc α-amino-β-ketoesters for the asymmetric synthesis of anti-N-Boc-β-hydroxy-α-amino esters.

Dynamic Kinetic Resolution: Asymmetric Transfer Hydrogenation of α-Alkyl-Substituted β-Ketoamides

2010 ◽  
Vol 12 (3) ◽  
pp. 512-515 ◽  
Author(s):  
John Limanto ◽  
Shane W. Krska ◽  
Benjamin T. Dorner ◽  
Enrique Vazquez ◽  
Naoki Yoshikawa ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
Transfer Hydrogenation ◽  
Asymmetric Transfer Hydrogenation ◽  
Dynamic Kinetic Resolution
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