Optically pure 2-(quinolin-8-yloxy)cyclohexan-1-ol as a practical agent for molecular recognition by NMR and fluorescence spectroscopy

2018 ◽  
Vol 54 (78) ◽  
pp. 11037-11040 ◽  
Author(s):  
Aditya N. Khanvilkar ◽  
Ashutosh V. Bedekar
Keyword(s):  
Molecular Recognition ◽  
Fluorescence Spectroscopy ◽  
Simple Chemical ◽  
Chiral Solvating Agent ◽  
Optically Pure

Optically pure 2-(quinolin-8-yloxy)cyclohexan-1-ol 1, obtained via simple chemical and bio-catalytic steps, was used as a chiral solvating agent for molecular recognition of the enantiomers of acids.

ChemInform Abstract: Synthesis of Novel Acridino- and Phenazino-18-crown-6 Ligands and Their Optically Pure Dimethyl-Substituted Analogues for Molecular Recognition Studies.

ChemInform ◽  
2010 ◽  
Vol 30 (24) ◽  
pp. no-no
Author(s):  
Peter Huszthy ◽  
Erika Samu ◽  
Borbala Vermes ◽  
Gabriella Mezey-Vandor ◽  
Mihaly Nogradi ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Optically Pure

scholarly journals Molecular Recognition of the HPLC Whelk-O1 Selector towards the Conformational Enantiomers of Nevirapine and Oxcarbazepine

2020 ◽  
Vol 22 (1) ◽  
pp. 144
Author(s):  
Roberta Franzini ◽  
Marco Pierini ◽  
Andrea Mazzanti ◽  
Antonia Iazzetti ◽  
Alessia Ciogli ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Chiral Stationary Phase ◽  
Stationary Phases ◽  
Chiral Hplc ◽  
Chromatographic Separations ◽  
Recognition Mechanism ◽  
Ambient Temperatures ◽  
Fast Exchange ◽  
Optically Pure ◽  
Vt Nmr

The presence of stereogenic elements is a common feature in pharmaceutical compounds, and affording optically pure stereoisomers is a frequent issue in drug design. In this context, the study of the chiral molecular recognition mechanism fundamentally supports the understanding and optimization of chromatographic separations with chiral stationary phases. We investigated, with molecular docking, the interactions between the chiral HPLC selector Whelk-O1 and the stereoisomers of two bioactive compounds, the antiviral Nevirapine and the anticonvulsant Oxcarbazepine, both characterized by two stereolabile conformational enantiomers. The presence of fast-exchange enantiomers and the rate of the interconversion process were studied using low temperature enantioselective HPLC and VT-NMR with Whelk-O1 applied as chiral solvating agent. The values of the energetic barriers of interconversion indicate, for the single enantiomers of both compounds, half-lives sufficiently long enough to allow their separation only at critically sub-ambient temperatures. The chiral selector Whelk-O1 performed as a strongly selective discriminating agent both when applied as a chiral stationary phase (CSP) in HPLC and as CSA in NMR spectroscopy.

Synthesis of novel acridino- and phenazino-18-crown-6 ligands and their optically pure dimethyl-substituted analogues for molecular recognition studies

Tetrahedron ◽  
1999 ◽  
Vol 55 (5) ◽  
pp. 1491-1504 ◽  
Author(s):  
Péter Huszthy ◽  
Erika Samu ◽  
Borbála Vermes ◽  
Gabriella Mezey-Vándor ◽  
Mihály Nógrádi ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Optically Pure

A preliminary study on the potential of front face fluorescence spectroscopy for the discrimination of Moroccan virgin olive oils and the prediction of their quality

2021 ◽  
Author(s):  
Hicham Zaroual ◽  
El Mestafa El Hadrami ◽  
Romdhane Karoui
Keyword(s):  
Fluorescence Spectroscopy ◽  
Olive Oil ◽  
Virgin Olive Oil ◽  
Front Face ◽  
Virgin Olive Oils ◽  
Olive Oils ◽  
Preliminary Study

This study examines the feasibility of using front face fluorescence spectroscopy (FFFS) to authenticate 41 virgin olive oil (VOO) samples collected from 5 regions in Morocco during 2 consecutive crop seasons.

Complexation of Synthetic Organic Dye Dapoxyl with cyclodextrins studied by fluorescence spectroscopy

2009 ◽  
Author(s):  
Wajih Al‐Soufi ◽  
Mercedes Novo ◽  
Jorge Bordello ◽  
Daniel Granadero
Keyword(s):  
Fluorescence Spectroscopy ◽  
Organic Dye
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