Active targeted drug delivery of MMP-2 sensitive polymeric nanoparticles

2018 ◽  
Vol 54 (79) ◽  
pp. 11092-11095 ◽  
Author(s):  
Jie Pan ◽  
Pei-Jiao Li ◽  
Yi Wang ◽  
Lu Chang ◽  
Dong Wan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Therapeutic Efficiency ◽  
Targeted Drug

MMP2-sensitive nanoparticles are developed with copolymers of TPGS3350-pp-PLGA and TPGS-folate in order to enhance the therapeutic efficiency of cancer.

scholarly journals Single-step surface functionalization of polymeric nanoparticles for targeted drug delivery

Biomaterials ◽  
2009 ◽  
Vol 30 (5) ◽  
pp. 859-866 ◽  
Author(s):  
Yogesh B. Patil ◽  
Udaya S. Toti ◽  
Ayman Khdair ◽  
Linan Ma ◽  
Jayanth Panyam
Keyword(s):  
Drug Delivery ◽  
Surface Functionalization ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Single Step ◽  
Targeted Drug

Herbal Based Polymeric Nanoparticles as a Therapeutic Remedy for Breast Cancer

2020 ◽  
Vol 20 ◽  
Author(s):  
Mohd Mughees ◽  
Saima Wajid
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Herbal Extract ◽  
Future Research ◽  
Delivery Methods ◽  
Cancer Breast ◽  
Conventional Drug ◽  
Targeted Drug

Background: The currently available anti breast cancer agents as well as conventional drug delivery methods have some limitations. Objective: In view of these limitations, researchers used phytochemicals/herbal extracts as anti-breast cancer agents together with the polymeric nanoparticles to provide an effective way of targeted drug delivery with lesser /no side effects. Methods: The literature for this review was searched during the year 2014 to 2018 by using the keywords, ‘ ‘breast cancer’, ‘breast cancer and its current treatments’, ‘plants against the breast cancer’, ‘polymeric nanoparticles’, ‘herbal based polymeric nanoparticles’. The databases i.e. PubMed, Science Direct and Google Scholar were used for collecting the information. Results: In the present review, we try to summarize the potential of herbal based nanoformulation as specific and high efficacy therapeutic strategy in order to pave a way for the future research involving screening and use of herbal nanoparticles for the treatment of breast cancer. Conclusion: The encapsulation of the herbal extract in the polymeric nanoparticles is the prominent, effective and emerging way of targeted drug delivery for cancer. It may serve as safer way of targeted drug delivery and may be the answer of the complications related to the currently available anti-breast cancer agents as well as limitations of conventional method of drug delivery.

Cytocompatible chitosan-graft-mPEG-based 5-fluorouracil-loaded polymeric nanoparticles for tumor-targeted drug delivery

2017 ◽  
Vol 44 (3) ◽  
pp. 365-376 ◽  
Author(s):  
M. Gover Antoniraj ◽  
Mahesh Ayyavu ◽  
Linda Jeeva Kumari Henry ◽  
Goutham Nageshwar Rao ◽  
Subramanian Natesan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Targeted Drug

Polymeric Nanoparticles for Tumor-Targeted Drug Delivery

2006 ◽  
pp. 215-229
Author(s):  
Tania Betancourt ◽  
Amber Doiron ◽  
Lisa Brannon-Peppas
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Targeted Drug

TEMPERATURE AND PH RESPONSIVE POLYMERIC NANOPARTICLES FOR TARGETED OXALIPLATIN DELIVERY

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (11) ◽  
pp. 74-77
Author(s):  
A. S Patil ◽  
◽  
A. P. Gadad
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Ph Responsive ◽  
In Vitro Drug Release ◽  
Dual Responsive ◽  
Targeted Drug ◽  
Targeted Drug Delivery System

In the present study temperature and pH responsive co-polymer chitosan-g-poly(N-isopropylacrylamide) (CS-g-PNIPAAm) was synthesized, characterized and efficiently loaded with oxaliplatin. Nanoparticles were evaluated for their physicochemical properties. The drug loaded nanoparticles showed smooth and spherical morphology with loading efficiency and drug content of about 80.7% and 48.7%, respectively. The in vitro drug release was significantly higher at tumor extracellular pH and temperature when compared to physiological pH and temperature. In conclusion, the developed nanoparticulate system is an effective dual responsive targeted drug delivery system for oxaliplatin with low toxic side effects.

Hypoxia-responsive polymeric nanoparticles for tumor-targeted drug delivery

Biomaterials ◽  
2014 ◽  
Vol 35 (5) ◽  
pp. 1735-1743 ◽  
Author(s):  
Thavasyappan Thambi ◽  
V.G. Deepagan ◽  
Hong Yeol Yoon ◽  
Hwa Seung Han ◽  
Seol-Hee Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Targeted Drug

Enzyme/pH dual sensitive polymeric nanoparticles for targeted drug delivery to the inflamed colon

2014 ◽  
Vol 123 ◽  
pp. 271-278 ◽  
Author(s):  
Muhammad Naeem ◽  
Wooseong Kim ◽  
Jiafu Cao ◽  
Yunjin Jung ◽  
Jin-Wook Yoo
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Polymeric Nanoparticles ◽  
Targeted Drug
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