A smart photosensitizer based on a red emitting solution processable porous polymer: generation of reactive oxygen species

2018 ◽  
Vol 54 (66) ◽  
pp. 9123-9126 ◽  
Author(s):  
Sujoy Bandyopadhyay ◽  
Subhankar Kundu ◽  
Arkaprabha Giri ◽  
Abhijit Patra
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Structure Activity Relationship ◽  
Porous Polymer ◽  
Organic Polymer ◽  
Activity Relationship ◽  
Oxygen Species ◽  
Porous Organic Polymer ◽  
Structure Activity ◽  
Solution Processable

An efficient photosensitizer was developed employing a red emitting soluble conjugated porous organic polymer and the structure–activity relationship was established.

scholarly journals 2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study

2010 ◽  
Vol 18 (18) ◽  
pp. 6776-6784 ◽  
Author(s):  
Clementina M.M. Santos ◽  
Marisa Freitas ◽  
Daniela Ribeiro ◽  
Ana Gomes ◽  
Artur M.S. Silva ◽  
...  
Keyword(s):  
Reactive Oxygen ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Nitrogen Species ◽  
Structure Activity ◽  
Relationship Study

A Review on Anticancer Potentials of Benzothiazole Derivatives

2020 ◽  
Vol 20 (1) ◽  
pp. 12-23 ◽  
Author(s):  
Nandini Pathak ◽  
Ekta Rathi ◽  
Nitesh Kumar ◽  
Suvarna G. Kini ◽  
C. Mallikarjuna Rao
Keyword(s):  
Biological Activities ◽  
Cancer Cell Line ◽  
Structure Activity Relationship ◽  
Potential Effect ◽  
Activity Relationship ◽  
Oxygen Species ◽  
Benzothiazole Derivatives ◽  
Structure Activity ◽  
Wide Range ◽  
Recent Trends

: Benzothiazole is an organic compound bearing a heterocyclic nucleus (thiazole) which imparts a broad spectrum of biological activities to it. The significant and potent activity of benzothiazole moiety influenced distinctively by nature and position of substitutions. This review summarizes the effect of various substituents in recent trends and approaches to design and develop novel benzothiazole derivatives for anticancer potential in different cell lines by interpreting the Structure- Activity Relationship (SAR) and mechanism of action of a wide range of derivatives. The list of derivatives is categorized into different groups and reviewed for their anticancer activity. The structure-activity relationship for the various derivatives revealed an excellent understanding of benzothiazole moiety in the field of cancer therapy against different cancer cell line. Data obtained from the various articles showed the potential effect of benzothiazole moiety and its derivatives to produce the peculiar and significant lead compound. The important anticancer mechanisms found are tyrosine kinase inhibition, topoisomerase inhibition and induction of apoptosis by Reactive Oxygen Species (ROS) activation. Therefore, the design and development of novel benzothiazole have broad scope in cancer chemotherapy.

scholarly journals Probing the Structure-Activity Relationship of an Antioxidant Tuna-Backbone Derived Peptide

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 398-398
Author(s):  
Varun Gopinatth ◽  
Elaine Ballinger ◽  
Jung Kwon
Keyword(s):  
Antioxidant Activity ◽  
Reactive Oxygen ◽  
Structure Activity Relationship ◽  
Peptide Sequence ◽  
Cellular Damage ◽  
Activity Relationship ◽  
Antioxidant Peptides ◽  
Antioxidant Peptide ◽  
Structure Activity ◽  
Relationship Of

Abstract Objectives DNA is easily degraded by reactive oxygen and nitrogen species, and once damaged can cause significant biological problems. Endogenous mechanisms exist to neutralize reactive oxygen species, but nutritional antioxidants provide extra protection against cellular damage. There is interest in identifying antioxidant peptide nutraceuticals that can provide health benefits when included in diets. Current research identifies antioxidant peptides from natural sources but often stops short of examining mechanisms for activity. An antioxidant peptide (APTBP) was previously characterized from tuna backbone protein. This study investigates the structure-activity relationship of APTBP to identify how the specific peptide sequence contributes to the antioxidant activity. Better understanding of the mechanism of antioxidant peptides can provide insight into future screens and combine with predictive software to identify potential antioxidative sequences from protein sources of interest. Methods Peptide array was synthesized by Thermo Fisher. Modifications were chosen in broad categories with possible mechanistic impact including altering the peptide PI, disrupting the secondary structure, increasing or decreasing hydrophobicity, and increasing aromaticity. The array was tested for activity based on the ability to scavenge ABTS free radical. Results APTBP analogs without hydrophilic, and aromatic residues showed significant loss of activity, up to 76.8%. Notably, substitution of a single tryptophan on either terminal end of the peptide resulted in up to 63.1% increased activity, while substitution of tryptophan on both ends decreased activity by 10.3%. Conclusions The antioxidant activity of APTBP is likely the result of a delicate interplay between amino acids in the peptide, but tryptophan residues had an important impact on activity. Tryptophan has an indole side chain, and is a non-polar, aromatic amino acid. The antioxidant activity of ABTBP is significantly linked to the presence of tryptophan, indicating that aromaticity and electron sharing contributes majorly to the ability of ABTBP to scavenge free radicals. The results from this study can help in future research that aims to identify other potential antioxidant peptides as well as ways to increase antioxidant activity of existing peptides. Funding Sources OSU Honors College.

N,N'-bicarbazole-benzothiadiazole-based conjugated porous organic polymer for reactive oxygen species generation in live cells

2021 ◽  
Author(s):  
Subhankar Kundu ◽  
Biswajit Behera ◽  
Arkaprabha Giri ◽  
Nitu Saha ◽  
Abhijit Patra
Keyword(s):  
Reactive Oxygen Species ◽  
Visible Light ◽  
Light Absorption ◽  
Reactive Oxygen Species Generation ◽  
Organic Polymer ◽  
Live Cells ◽  
Oxygen Species ◽  
Visible Light Absorption ◽  
Porous Organic Polymer ◽  
Water Dispersible

A π-conjugated porous organic polymer (BCzBz) was fabricated employing N,N'-bicarbazole and benzothiadiazole as molecular building units exhibiting broad visible light absorption. The photostable, water-dispersible, and cytocompatible BCzBz was demonstrated as...

Mitochondria as a source of reactive oxygen species

2009 ◽  
pp. c3 ◽  
Author(s):  
Helena M. Cochemé ◽  
Michael P. Murphy
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Oxygen Species

Clinical aspects of reactive oxygen and nitrogen species

2004 ◽  
Vol 71 ◽  
pp. 121-133 ◽  
Author(s):  
Ascan Warnholtz ◽  
Maria Wendt ◽  
Michael August ◽  
Thomas Münzel
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Risk Factor ◽  
Endothelial Dysfunction ◽  
Vascular Tissue ◽  
Rapid Development ◽  
Reactive Oxygen ◽  
Clinical Aspects ◽  
No Production ◽  
Oxygen Species

Endothelial dysfunction in the setting of cardiovascular risk factors, such as hypercholesterolaemia, hypertension, diabetes mellitus and chronic smoking, as well as in the setting of heart failure, has been shown to be at least partly dependent on the production of reactive oxygen species in endothelial and/or smooth muscle cells and the adventitia, and the subsequent decrease in vascular bioavailability of NO. Superoxide-producing enzymes involved in increased oxidative stress within vascular tissue include NAD(P)H-oxidase, xanthine oxidase and endothelial nitric oxide synthase in an uncoupled state. Recent studies indicate that endothelial dysfunction of peripheral and coronary resistance and conductance vessels represents a strong and independent risk factor for future cardiovascular events. Ways to reduce endothelial dysfunction include risk-factor modification and treatment with substances that have been shown to reduce oxidative stress and, simultaneously, to stimulate endothelial NO production, such as inhibitors of angiotensin-converting enzyme or the statins. In contrast, in conditions where increased production of reactive oxygen species, such as superoxide, in vascular tissue is established, treatment with NO, e.g. via administration of nitroglycerin, results in a rapid development of endothelial dysfunction, which may worsen the prognosis in patients with established coronary artery disease.

Fas ligand expression in rat kupffer cells in response to lipopolysaccharide is mediated by reactive oxygen species

2001 ◽  
Vol 120 (5) ◽  
pp. A361-A361
Author(s):  
K UCHIKURA ◽  
T WADA ◽  
Z SUN ◽  
S HOSHINO ◽  
G BULKLEY ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Kupffer Cells ◽  
Fas Ligand ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Ligand Expression
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