Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

Mu Yang; Hanzhi Wu; Julie Chu; Lucas A. Gabriel; Y. Kim; Karen S. Anderson; Cristina M. Furdui; Ulrich Bierbach

doi:10.1039/c8cc04251a

Platination of cysteine by an epidermal growth factor receptor kinase-targeted hybrid agent

Chemical Communications ◽

10.1039/c8cc04251a ◽

2018 ◽

Vol 54 (54) ◽

pp. 7479-7482 ◽

Cited By ~ 2

Author(s):

Mu Yang ◽

Hanzhi Wu ◽

Julie Chu ◽

Lucas A. Gabriel ◽

Y. Kim ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Cysteine Residue ◽

Receptor Kinase ◽

Epidermal Growth ◽

Hybrid Agent ◽

Egfr Kinase

Platinum-modified tyrosine kinase inhibitors show strong and selective EGFR kinase binding and form adducts with a pharmacologically relevant cysteine residue.

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Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-Deficient and PTEN-Intact Glioblastoma Cells

Cancer Research ◽

10.1158/0008-5472.can-04-4392 ◽

2006 ◽

Vol 66 (16) ◽

pp. 7864-7869 ◽

Cited By ~ 176

Author(s):

Maria Y. Wang ◽

Kan V. Lu ◽

Shaojun Zhu ◽

Ederlyn Q. Dia ◽

Igor Vivanco ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Mammalian Target Of Rapamycin ◽

Growth Factor Receptor ◽

Target Of Rapamycin ◽

Receptor Kinase ◽

Glioblastoma Cells ◽

Epidermal Growth

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Tricyclic Azepine Derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a Novel Class of Epidermal Growth Factor Receptor Kinase Inhibitors.

ChemInform ◽

10.1002/chin.200623175 ◽

2006 ◽

Vol 37 (23) ◽

Author(s):

Evgueni L. Piatnitski ◽

et al. et al.

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth

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Four-membered heterocycles-containing 4-anilino-quinazoline derivatives as epidermal growth factor receptor (EGFR) kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.07.049 ◽

2013 ◽

Vol 23 (19) ◽

pp. 5385-5388 ◽

Cited By ~ 14

Author(s):

Feng Zhao ◽

Zhaohu Lin ◽

Feng Wang ◽

Weili Zhao ◽

Xiaochun Dong

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Quinazoline Derivatives ◽

Egfr Kinase

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PTEN-Mediated Resistance to Epidermal Growth Factor Receptor Kinase Inhibitors

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-06-1992 ◽

2007 ◽

Vol 13 (2) ◽

pp. 378-381 ◽

Cited By ~ 76

Author(s):

Ingo K. Mellinghoff ◽

Tim F. Cloughesy ◽

Paul S. Mischel

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth

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Treatment of Squamous Cell Carcinoma of the Head and Neck in the Metastatic and Refractory Settings: Advances in Chemotherapy and the Emergence of Small Molecule Epidermal Growth Factor Receptor Kinase Inhibitors

Current Cancer Drug Targets ◽

10.2174/156800907782418293 ◽

2007 ◽

Vol 7 (7) ◽

pp. 666-673 ◽

Cited By ~ 17

Author(s):

Syed Ahmed ◽

Ezra Cohen

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Cell Carcinoma ◽

Small Molecule ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth

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Interactions of ABCG2 (BCRP) with epidermal growth factor receptor kinase inhibitors developed for molecular imaging

Frontiers in Pharmacology ◽

10.3389/fphar.2014.00257 ◽

2014 ◽

Vol 5 ◽

Cited By ~ 2

Author(s):

Israa Qawasmi ◽

Miriam Shmuel ◽

Sara Eyal

Keyword(s):

Epidermal Growth Factor Receptor ◽

Molecular Imaging ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth

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Epidermal Growth Factor Receptor Kinase Inhibitors Synergize with TCDD to Induce CYP1A1/1A2 in Human Breast Epithelial MCF10A Cells

Drug Metabolism and Disposition ◽

10.1124/dmd.115.066274 ◽

2016 ◽

Vol 44 (5) ◽

pp. 665-671 ◽

Cited By ~ 3

Author(s):

A. Joiakim ◽

P. A. Mathieu ◽

C. Shelp ◽

J. Boerner ◽

J. J. Reiners

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Human Breast ◽

Epidermal Growth ◽

Breast Epithelial ◽

Mcf10a Cells

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Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2005.12.018 ◽

2006 ◽

Vol 16 (6) ◽

pp. 1643-1646 ◽

Cited By ~ 9

Author(s):

Leon Smith ◽

Evgueni L. Piatnitski ◽

Alexander S. Kiselyov ◽

Xiaohu Ouyang ◽

Xiaoling Chen ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth

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Acquired resistance to epidermal growth factor receptor (EGFR) kinase inhibitors associated with a novel T854A mutation in a patient with EGFR-mutant lung adenocarcinoma

Journal of Clinical Oncology ◽

10.1200/jco.2008.26.15_suppl.8056 ◽

2008 ◽

Vol 26 (15_suppl) ◽

pp. 8056-8056

Author(s):

J. Bean ◽

G. J. Riely ◽

M. Balak ◽

J. L. Marks ◽

M. Ladanyi ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Lung Adenocarcinoma ◽

Kinase Inhibitors ◽

Acquired Resistance ◽

Growth Factor Receptor ◽

Epidermal Growth ◽

Egfr Mutant ◽

Egfr Kinase

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Corrigendum to “Tricyclic azepine derivatives: Pyrimido[4,5-b]-1,4-benzoxazepines as a novel class of epidermal growth factor receptor kinase inhibitors” [Bioorg. Med. Chem. Lett. 16 (2006) 1643–1646]

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2006.04.058 ◽

2006 ◽

Vol 16 (14) ◽

pp. 3869

Author(s):

Leon Smith ◽

Evgueni L. Piatnitski ◽

Alexander S. Kiselyov ◽

Xiaohu Ouyang ◽

Xiaoling Chen ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Receptor Kinase ◽

Epidermal Growth

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