Label-free and high-throughput bioluminescence detection of uracil-DNA glycosylase in cancer cells through tricyclic cascade signal amplification

2018 ◽  
Vol 54 (51) ◽  
pp. 6991-6994 ◽  
Author(s):  
Yan Zhang ◽  
Qing-nan Li ◽  
Chen-chen Li ◽  
Chun-yang Zhang
Keyword(s):  
Cancer Cells ◽  
High Throughput ◽  
Signal Amplification ◽  
Sensitive Detection ◽  
Dna Glycosylase ◽  
Label Free ◽  
Uracil Dna Glycosylase ◽  
Bioluminescence Method

We develop a label-free and high-throughput bioluminescence method for the sensitive detection of uracil DNA glycosylase through tricyclic cascade signal amplification.

Simple label-free and sensitive fluorescence determination of human 8-oxoG DNA glycosylase 1 activity and inhibitionviaTdT-assisted sequence extension amplification

2019 ◽  
Vol 43 (21) ◽  
pp. 8260-8265
Author(s):  
Sujing Wang ◽  
Daxiu Li ◽  
Ruo Yuan ◽  
Yun Xiang
Keyword(s):  
Signal Amplification ◽  
Sensitive Detection ◽  
Dna Glycosylase ◽  
Label Free ◽  
Fluorescence Determination

Label-free and sensitive detection of hOGG1 activity and inhibitionviaTdT-assisted sequence extension signal amplification.

A label-free and sensitive fluorescent method for the detection of uracil-DNA glycosylase activity

2015 ◽  
Vol 51 (5) ◽  
pp. 929-932 ◽  
Author(s):  
Jing Tao ◽  
Panshu Song ◽  
Yusuke Sato ◽  
Seiichi Nishizawa ◽  
Norio Teramae ◽  
...  
Keyword(s):  
Sensitive Detection ◽  
Dna Glycosylase ◽  
Label Free ◽  
Uracil Dna Glycosylase ◽  
Fluorescent Method

A label-free fluorescent method has been developed for sensitive detection of uracil-DNA glycosylase activity as well as UDG inhibitors.

A label free fluorescent assay for uracil-DNA glycosylase activity based on the signal amplification of exonuclease I

RSC Advances ◽  
2015 ◽  
Vol 5 (98) ◽  
pp. 80871-80874 ◽  
Author(s):  
Yefei Ma ◽  
Jingjin Zhao ◽  
Xuejun Li ◽  
Liangliang Zhang ◽  
Shulin Zhao
Keyword(s):  
Signal Amplification ◽  
Dna Glycosylase ◽  
Label Free ◽  
Fluorescent Assay ◽  
Uracil Dna Glycosylase ◽  
Exonuclease I

A label free fluorescent assay for uracil-DNA glycosylase activity was developed based on the signal amplification of exonuclease I.

Label-free and sensitive detection of uracil-DNA glycosylase using exponential real-time rolling circle amplification

2018 ◽  
Vol 10 (20) ◽  
pp. 2405-2410 ◽  
Author(s):  
Yuan Xu ◽  
Yun-Xi Cui ◽  
Qiu-Ge Zhao ◽  
An-Na Tang ◽  
De-Ming Kong
Keyword(s):  
Real Time ◽  
Rolling Circle Amplification ◽  
Sensitive Detection ◽  
Dna Glycosylase ◽  
Label Free ◽  
Uracil Dna Glycosylase ◽  
Schematic Representation ◽  
Rolling Circle ◽  
Sensing Platform ◽  
Activity Sensing

Schematic representation of an exponential rolling circle amplification-based uracil-DNA glycosylase activity-sensing platform.

scholarly journals Simultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level

2018 ◽  
Vol 9 (3) ◽  
pp. 712-720 ◽  
Author(s):  
Juan Hu ◽  
Ming-hao Liu ◽  
Ying Li ◽  
Bo Tang ◽  
Chun-yang Zhang
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Single Molecule ◽  
Simultaneous Detection ◽  
Sensitive Detection ◽  
Lung Cancer Cells ◽  
Dna Glycosylase ◽  
Dna Glycosylases ◽  
Single Molecule Level ◽  
Alkyladenine Dna Glycosylase

We demonstrate the simultaneous detection of human 8-oxoguanine DNA glycosylase 1 and human alkyladenine DNA glycosylase at the single-molecule level.

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