Formation mechanism of rectangular-ambulatory-plane TiO2 plates: an insight into the role of hydrofluoric acid

2018 ◽  
Vol 54 (52) ◽  
pp. 7191-7194 ◽  
Author(s):  
Yajun Zou ◽  
Ge Gao ◽  
Zhenyu Wang ◽  
Jian-Wen Shi ◽  
Hongkang Wang ◽  
...  
Keyword(s):  
Formation Mechanism ◽  
Hydrofluoric Acid ◽  
First Time ◽  
Insight Into

A novel rectangular-ambulatory-plane TiO2 plate with exposed {001} facets was developed for the first time, and its formation mechanism was well revealed.

Strategic Relations and Sport Policy Making: The Case of Aerobic Union and School Sports Federation Bulgaria

2001 ◽  
Vol 15 (3) ◽  
pp. 173-194 ◽  
Author(s):  
Vassil Girginov
Keyword(s):  
Policy Making ◽  
Strategic Orientation ◽  
Communist State ◽  
Sport Policy ◽  
School Sports ◽  
Totalitarian Regimes ◽  
First Time ◽  
Insight Into ◽  
Relation Perspective

The dismissal of totalitarian regimes across Eastern Europe challenged the strategic orientation of sport in these countries. A central issue concerning the shaping of the new sport policies and the role of democratic states surprisingly as yet has not generated thorough academic analyses. As a result of transformations, the sport sector is undergoing massive adaptations, innovations, and reconfigurations leading to the emergence of new arrangements and actors pursuing different projects. Studying this process from a Strategic Relation perspective invites an analysis of sports policy, which accounts equally for events, actors, structures, and relations. More specifically, this approach offered a fruitful insight into the state and its strategic relations in sport policy making. One aspect of this study of theoretical interest is that, so far as can be ascertained, it is the first time the Strategic Relations approach has been applied to a Communist state.

scholarly journals Bayogenin 3-O-Cellobioside is a novel non-cultivar specific anti-blast metabolite produced in rice in response to Pyricularia oryzae infection

2019 ◽  
Author(s):  
Justice Norvienyeku ◽  
Lili Lin ◽  
Abdul Waheed ◽  
Xiaomin Chen ◽  
Jiandong Bao ◽  
...  
Keyword(s):  
Control Strategy ◽  
Host Resistance ◽  
Blast Resistance ◽  
Differential Resistance ◽  
Host Immunity ◽  
Cereal Crops ◽  
Rice Cultivars ◽  
First Time ◽  
Insight Into

AbstractRice cultivars from japonica and indica lineage possess differential resistance against blast fungus on an account genetic divergence. Whether different rice cultivars also show distinct metabolomic changes in response to P. oryzae, and their role in host resistance, are poorly understood. Here, we examine the responses of six different rice cultivars from japonica and indica lineage challenged with P. oryzae. Both susceptible and resistant rice cultivars expressed several metabolites exclusively during P. oryzae infection, including the saponin Bayogenin 3-O-cellobioside. Bayogenin 3-O-cellobioside level in infected rice directly correlated with their resistant attributes. These findings reveal, for the first time to our knowledge that besides oat, other grass plants including rice produces protective saponins. Our study provides insight into the role of pathogen-mediated metabolomics-reprogramming in host immunity. The correlation between Bayogenin 3-O-Cellobioside levels and blast resistance suggests that engineering saponin expression in cereal crops represents an attractive and sustainable disease control strategy.

scholarly journals Novel Insight Into the Development and Function of Hypopharyngeal Glands in Honey Bees

2021 ◽  
Vol 11 ◽  
Author(s):  
Saboor Ahmad ◽  
Shahmshad Ahmed Khan ◽  
Khalid Ali Khan ◽  
Jianke Li
Keyword(s):  
Honey Bees ◽  
Future Research ◽  
Factors Affecting ◽  
Hypopharyngeal Glands ◽  
And Function ◽  
First Time ◽  
The Brain ◽  
Insight Into ◽  
Made In

Hypopharyngeal glands (HGs) are the most important organ of hymenopterans which play critical roles for the insect physiology. In honey bees, HGs are paired structures located bilaterally in the head, in front of the brain between compound eyes. Each gland is composed of thousands of secretory units connecting to secretory duct in worker bees. To better understand the recent progress made in understanding the structure and function of these glands, we here review the ontogeny of HGs, and the factors affecting the morphology, physiology, and molecular basis of the functionality of the glands. We also review the morphogenesis of HGs in the pupal and adult stages, and the secretory role of the glands across the ages for the first time. Furthermore, recent transcriptome, proteome, and phosphoproteome analyses have elucidated the potential mechanisms driving the HGs development and functionality. This adds a comprehensive novel knowledge of the development and physiology of HGs in honey bees over time, which may be helpful for future research investigations.

scholarly journals Pseudomonas chlororaphis Produces Two Distinct R-Tailocins That Contribute to Bacterial Competition in Biofilms and on Roots

2017 ◽  
Vol 83 (15) ◽  
Author(s):  
Robert J. Dorosky ◽  
Jun Myoung Yu ◽  
Leland S. Pierson ◽  
Elizabeth A. Pierson
Keyword(s):  
Gene Cluster ◽  
Gene Clusters ◽  
Associated Bacteria ◽  
Content Type ◽  
Bacterial Competition ◽  
Transmission Electron ◽  
Lysis Cassette ◽  
First Time ◽  
Insight Into

ABSTRACT R-type tailocins are high-molecular-weight bacteriocins that resemble bacteriophage tails and are encoded within the genomes of many Pseudomonas species. In this study, analysis of the P. chlororaphis 30-84 R-tailocin gene cluster revealed that it contains the structural components to produce two R-tailocins of different ancestral origins. Two distinct R-tailocin populations differing in length were observed in UV-induced lysates of P. chlororaphis 30-84 via transmission electron microscopy. Mutants defective in the production of one or both R-tailocins demonstrated that the killing spectrum of each tailocin is limited to Pseudomonas species. The spectra of pseudomonads killed by the two R-tailocins differed, although a few Pseudomonas species were either killed by or insusceptible to both tailocins. Tailocin release was disrupted by deletion of the holin gene within the tailocin gene cluster, demonstrating that the lysis cassette is required for the release of both R-tailocins. The loss of functional tailocin production reduced the ability of P. chlororaphis 30-84 to compete with an R-tailocin-sensitive strain within biofilms and rhizosphere communities. Our study demonstrates that Pseudomonas species can produce more than one functional R-tailocin particle sharing the same lysis cassette but differing in their killing spectra. This study provides evidence for the role of R-tailocins as determinants of bacterial competition among plant-associated Pseudomonas in biofilms and the rhizosphere. IMPORTANCE Recent studies have identified R-tailocin gene clusters potentially encoding more than one R-tailocin within the genomes of plant-associated Pseudomonas but have not demonstrated that more than one particle is produced or the ecological significance of the production of multiple R-tailocins. This study demonstrates for the first time that Pseudomonas strains can produce two distinct R-tailocins with different killing spectra, both of which contribute to bacterial competition between rhizosphere-associated bacteria. These results provide new insight into the previously uncharacterized role of R-tailocin production by plant-associated Pseudomonas species in bacterial population dynamics within surface-attached biofilms and on roots.

scholarly journals Design of Conditionally Active STATs: Insights into STAT Activation and Gene Regulatory Function

1999 ◽  
Vol 19 (4) ◽  
pp. 2913-2920 ◽  
Author(s):  
Lawrence H. Milocco ◽  
Jennifer A. Haslam ◽  
Jonathan Rosen ◽  
H. Martin Seidel
Keyword(s):  
Tyrosine Phosphorylation ◽  
Nuclear Translocation ◽  
Regulatory Function ◽  
Nuclear Localization Sequence ◽  
Wild Type ◽  
Localization Sequence ◽  
Gene Regulatory ◽  
First Time ◽  
Insight Into

ABSTRACT The STAT (signal transducer and activator of transcription) signaling pathway is activated by a large number of cytokines and growth factors. We sought to design a conditionally active STAT that could not only provide insight into basic questions about STAT function but also serve as a powerful tool to determine the precise biological role of STATs. To this end, we have developed a conditionally active STAT by fusing STATs with the ligand-binding domain of the estrogen receptor (ER). We have demonstrated that the resulting STAT-ER chimeras are estrogen-inducible transcription factors that retain the functional and biochemical characteristics of the cognate wild-type STATs. In addition, these tools have allowed us to evaluate separately the contribution of tyrosine phosphorylation and dimerization to STAT function. We have for the first time provided experimental data supporting the model that the only apparent role of STAT tyrosine phosphorylation is to drive dimerization, as dimerization alone is sufficient to unmask a latent STAT nuclear localization sequence and induce nuclear translocation, sequence-specific DNA binding, and transcriptional activity.

scholarly journals The function of LncRNA-H19 in cardiac hypertrophy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Wenhua Su ◽  
Qian Huo ◽  
Hao Wu ◽  
Lulin Wang ◽  
Xiaoxue Ding ◽  
...  
Keyword(s):  
Cardiac Hypertrophy ◽  
Adaptive Response ◽  
Molecular Mechanisms ◽  
Myocardial Hypertrophy ◽  
Noncoding Rnas ◽  
Biological Functions ◽  
Pathological Mechanism ◽  
First Time ◽  
Insight Into

AbstractCardiac hypertrophy, characterized by the enlargement of cardiomyocytes, is initially an adaptive response to physiological and pathological stimuli. Decompensated cardiac hypertrophy is related to fibrosis, inflammatory cytokine, maladaptive remodeling, and heart failure. Although pathological myocardial hypertrophy is the main cause of hypertrophy-related morbidity and mortality, our understanding of its mechanism is still poor. Long noncoding RNAs (lncRNAs) are noncoding RNAs that regulate various physiological and pathological processes through multiple molecular mechanisms. Recently, accumulating evidence has indicated that lncRNA-H19 is a potent regulator of the progression of cardiac hypertrophy. For the first time, this review summarizes the current studies about the role of lncRNA-H19 in cardiac hypertrophy, including its pathophysiological processes and underlying pathological mechanism, including calcium regulation, fibrosis, apoptosis, angiogenesis, inflammation, and methylation. The context within which lncRNA-H19 might be developed as a target for cardiac hypertrophy treatment is then discussed to gain better insight into the possible biological functions of lncRNA-H19 in cardiac hypertrophy.

scholarly journals SUMOylome Modulates Intraflagellar Transport Machinery and Eukaryotic Cilia Motility

2021 ◽  
Author(s):  
Komal Sharma ◽  
Irina Sizova ◽  
Girdhar Pandey ◽  
Peter Hegemann ◽  
Suneel Kateriya
Keyword(s):  
Functional Role ◽  
Intraflagellar Transport ◽  
Small Gtpase ◽  
The Other ◽  
Signaling Proteins ◽  
Sumoylation Site ◽  
C Terminus ◽  
First Time ◽  
Insight Into

Abstract Translocation of channelrhodopsins (ChRs) is mediated by intraflagellar transport (IFT) machinery. However, the functional role of the network containing photoreceptors, IFT and other proteins in controlling cilia motility of the alga is still not fully delineated. In the current study, we identified two important motifs at the C-terminus of ChR1. One of them is similar to a known ciliary targeting sequence that specifically interacts with a small GTPase, and the other is a SUMOylation site. For the first time, experimental data provide an insight into the role of SUMOylation in the modulation of IFT & ChR1. Blocking of SUMOylation affected the phototaxis of C. reinhardtii cells. This implies SUMOylation based regulation of protein network controlling photomotility. The conservation of SUMOylation site pattern as analyzed for the relevant photoreceptors, IFT and its associated signaling proteins in other ciliated green algae suggested SUMOylation based photobehavioural response across the microbes. This report establishes a link between evolutionary conserved SUMOylation and ciliary machinery for the maintenance and functioning of cilia across the eukaryotes. Our enriched SUMOylome of C. reinhardtii comprehends the proteins related to ciliary development and, photo-signaling, along with homologue(s) associated to human ciliopathies as SUMO targets.

ReFocus: The Films of Paul Schrader

2020 ◽  
Keyword(s):  
Film Criticism ◽  
Taxi Driver ◽  
Publication Date ◽  
Definition Of ◽  
First Time ◽  
Insight Into ◽  
Unique Relationship ◽  
Analytical Writing

Paul Schrader’s unique relationship to the role of the author (as screenwriter, director and critic) has long informed his cinema, and raises complicated questions about the definition of the auteur. This volume of essays – the first collection to assess Schrader’s contributions to directing, screenwriting and criticism – includes the first original appraisals of his much-lauded masterpiece First Reformed (2017), as well as a chapter-length interview with Schrader himself, conducted by the editors, in which Schrader examines the arc of his career for the first time and revises previous statements about filmmaking and film criticism. Providing a comprehensive exploration of his groundbreaking achievements in cinema, the book considers Schrader’s more overlooked films and provides new insights to their connection with his celebrated work in direction and screenwriting such as Taxi Driver (1976), Cat People (1982) and The Comfort of Strangers (1990). In doing so, it provides a valuable update to previous texts on Schrader and contains chapters on Schrader’s work since 2008, the publication date of the last book on his filmmaking. Where this study distinguishes itself fully is in its inclusion of a serious treatment of Schrader’s own film criticism and analytical writing. This collected writing provides unique access into how Schrader approaches the analysis of films and provides insight into his own work and others as “transcendental” filmmakers.

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