Towards single-molecule in situ electrochemical SERS detection with disposable substrates

2018 ◽  
Vol 54 (45) ◽  
pp. 5748-5751 ◽  
Author(s):  
Daniel Martín-Yerga ◽  
Alejandro Pérez-Junquera ◽  
María Begoña González-García ◽  
David Hernández-Santos ◽  
Pablo Fanjul-Bolado
Keyword(s):  
Surface Charge ◽  
Single Molecule ◽  
Electrochemical Activation ◽  
Sers Substrates ◽  
Active Surfaces ◽  
Highly Active ◽  
Sers Detection

Nanostructure and surface charge can be tuned during the electrochemical activation of SERS substrates achieving highly active surfaces with feasible detection of a few molecules.

scholarly journals Electrical and SERS detection of disulfide-mediated dimerization in single-molecule benzene-1,4-dithiol junctions

2018 ◽  
Vol 9 (22) ◽  
pp. 5033-5038 ◽  
Author(s):  
Jueting Zheng ◽  
Junyang Liu ◽  
Yijing Zhuo ◽  
Ruihao Li ◽  
Xi Jin ◽  
...  
Keyword(s):  
Single Molecule ◽  
Sers Detection

Electrical and in situ SERS characterization of the benzene-1,4-dithiol (BDT) junction suggested that dimerization of BDT contributed to the low conductance.

scholarly journals Development and Application of Aptamer-Based Surface-Enhanced Raman Spectroscopy Sensors in Quantitative Analysis and Biotherapy

Sensors ◽  
2019 ◽  
Vol 19 (17) ◽  
pp. 3806 ◽  
Author(s):  
Hai-Xia Wang ◽  
Yu-Wen Zhao ◽  
Zheng Li ◽  
Bo-Shi Liu ◽  
Di Zhang
Keyword(s):  
Surface Enhanced Raman Spectroscopy ◽  
Raman Signal ◽  
Label Free ◽  
Sers Substrates ◽  
Highly Active ◽  
Detection Technology ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Target Molecules

Surface-enhanced Raman scattering (SERS) is one of the most special and important Raman techniques. An apparent Raman signal can be observed when the target molecules are absorbed onto the surface of the SERS substrates, especially on the “hot spots” of the substrates. Early research focused on exploring the highly active SERS substrates and their detection applications in label-free SERS technology. However, it is a great challenge to use these label-free SERS sensors for detecting hydrophobic or non-polar molecules, especially in complex systems or at low concentrations. Therefore, antibodies, aptamers, and antimicrobial peptides have been used to effectively improve the target selectivity and meet the analysis requirements. Among these selective elements, aptamers are easy to use for synthesis and modifications, and their stability, affinity and specificity are extremely good; they have been successfully used in a variety of testing areas. The combination of SERS detection technology and aptamer recognition ability not only improved the selection accuracy of target molecules, but also improved the sensitivity of the analysis. Variations of aptamer-based SERS sensors have been developed and have achieved satisfactory results in the analysis of small molecules, pathogenic microorganism, mycotoxins, tumor marker and other functional molecules, as well as in successful photothermal therapy of tumors. Herein, we present the latest advances of the aptamer-based SERS sensors, as well as the assembling sensing platforms and the strategies for signal amplification. Furthermore, the existing problems and potential trends of the aptamer-based SERS sensors are discussed.

scholarly journals In situ modulation of gold nanorod's surface charge drives the growth of end-to-end assemblies from dimers to large networks that enhance single-molecule fluorescence by 10 000-fold

2020 ◽  
Vol 2 (7) ◽  
pp. 2688-2692
Author(s):  
Ashish Kar ◽  
Varsha Thambi ◽  
Diptiranjan Paital ◽  
Saumyakanti Khatua
Keyword(s):  
Surface Charge ◽  
Single Molecule ◽  
Hot Spots ◽  
Plasmonic Nanostructures ◽  
Single Molecule Fluorescence ◽  
Large Networks ◽  
End To End

End-to-end assemblies of anisotropic plasmonic nanostructures with small nanogaps are of great interest as they create strong hot spots for enhancing weak fluorescence and/or scattering of molecules.

Highly active Au NP microarray films for direct SERS detection

2019 ◽  
Vol 7 (48) ◽  
pp. 15259-15268 ◽  
Author(s):  
Lingling Zhang ◽  
Xiaodie Li ◽  
Weihua Liu ◽  
Rui Hao ◽  
Hongrui Jia ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Au Nanoparticles ◽  
Three Dimensional ◽  
Pdms Film ◽  
Highly Active ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Sers Detection ◽  
Enhanced Raman Scattering

In this study, we demonstrated a flexible transparent three-dimensional (3D) ordered micro-hemisphere (MHS) array PDMS film with self-assembled Au nanoparticles (NPs) (an Au NP-MHS array film) as a surface-enhanced Raman scattering (SERS) platform for the in situ detection of pesticides in food.

In Situ Activated Co3–xNixO4 as a Highly Active and Ultrastable Electrocatalyst for Hydrogen Generation

ACS Catalysis ◽  
2021 ◽  
pp. 8174-8182
Author(s):  
Kailu Guo ◽  
Yantao Wang ◽  
Junfeng Huang ◽  
Min Lu ◽  
Hua Li ◽  
...  
Keyword(s):  
Hydrogen Generation ◽  
Highly Active

Macroscopical monolayer films of ordered arrays of gold nanoparticles as SERS substrates for in-situ quantitative detection in aqueous solutions

Nanoscale ◽  
2021 ◽  
Author(s):  
Lixiang Xing ◽  
Cui Wang ◽  
Yi Cao ◽  
Jihui Zhang ◽  
Haibing Xia
Keyword(s):  
Gold Nanoparticles ◽  
Volume Fraction ◽  
Water Volume ◽  
Quantitative Detection ◽  
Monolayer Films ◽  
Au Nps ◽  
Sers Substrates ◽  
Ordered Arrays ◽  
Water Volume Fraction

In this work, macroscopical monolayer films of ordered arrays of gold nanoparticles (MMF-OA-Au NPs) are successfully prepared at the interfaces of toluene-diethylene glycol (DEG) with a water volume fraction of...

scholarly journals Tuning Single-Molecule Conductance by Controlled Electric Field-Induced trans-to-cis Isomerisation

2021 ◽  
Vol 11 (8) ◽  
pp. 3317
Author(s):  
C.S. Quintans ◽  
Denis Andrienko ◽  
Katrin F. Domke ◽  
Daniel Aravena ◽  
Sangho Koo ◽  
...  
Keyword(s):  
Electric Field ◽  
Electric Fields ◽  
Single Molecule ◽  
Quantum Interference ◽  
Single Molecule Level ◽  
Wet Chemical Synthesis ◽  
Single Molecule Junctions ◽  
Tunnelling Microscopy ◽  
The Difference

External electric fields (EEFs) have proven to be very efficient in catalysing chemical reactions, even those inaccessible via wet-chemical synthesis. At the single-molecule level, oriented EEFs have been successfully used to promote in situ single-molecule reactions in the absence of chemical catalysts. Here, we elucidate the effect of an EEFs on the structure and conductance of a molecular junction. Employing scanning tunnelling microscopy break junction (STM-BJ) experiments, we form and electrically characterize single-molecule junctions of two tetramethyl carotene isomers. Two discrete conductance signatures show up more prominently at low and high applied voltages which are univocally ascribed to the trans and cis isomers of the carotenoid, respectively. The difference in conductance between both cis-/trans- isomers is in concordance with previous predictions considering π-quantum interference due to the presence of a single gauche defect in the trans isomer. Electronic structure calculations suggest that the electric field polarizes the molecule and mixes the excited states. The mixed states have a (spectroscopically) allowed transition and, therefore, can both promote the cis-isomerization of the molecule and participate in electron transport. Our work opens new routes for the in situ control of isomerisation reactions in single-molecule contacts.

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