Palladium/H+-cocatalyzed kinetic resolution of tertiary propargylic alcohols

2018 ◽  
Vol 54 (47) ◽  
pp. 6064-6067 ◽  
Author(s):  
Wanli Zhang ◽  
Shengming Ma
Keyword(s):  
Kinetic Resolution ◽  
Optically Active ◽  
Propargylic Alcohols

A new concept for the synthesis of optically active tertiary propargylic alcohols with 90–99% ee through palladium/H+-cocatalyzed kinetic resolution was developed.

Kinetic resolution of N-methyl-2-phenylpyrrolidine by cyclopalladation in the presence of an optically active base

1999 ◽  
Vol 35 (8) ◽  
pp. 1001-1011 ◽  
Author(s):  
V. V. Dunina ◽  
L. G. Kuz'mina ◽  
E. D. Razmyslova ◽  
V. P. Kislyi
Keyword(s):  
Kinetic Resolution ◽  
Optically Active ◽  
Active Base

Optically Active Amines by Enzyme-Catalyzed Kinetic Resolution

Synthesis ◽  
2008 ◽  
Vol 2008 (14) ◽  
pp. 2283-2287 ◽  
Author(s):  
Klaus Ditrich
Keyword(s):  
Kinetic Resolution ◽  
Optically Active

scholarly journals Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral Acyl-Transfer Catalyst

Molecules ◽  
2018 ◽  
Vol 23 (8) ◽  
pp. 2003 ◽  
Author(s):  
Takatsugu Murata ◽  
Tatsuya Kawanishi ◽  
Akihiro Sekiguchi ◽  
Ryo Ishikawa ◽  
Keisuke Ono ◽  
...  
Keyword(s):  
Kinetic Resolution ◽  
High Selectivity ◽  
Optically Active ◽  
Acyl Transfer ◽  
Chiral Compounds ◽  
Tertiary Amide

Various optically active 2-hydroxyamide derivatives are produced based on the kinetic resolution of racemic 2-hydroxyamides with a diphenylacetyl component and (R)-benzotetramisole ((R)-BTM), a chiral acyl-transfer catalyst, via asymmetric esterification and acylation. It was revealed that a tertiary amide can be used with this novel protocol to achieve high selectivity (22 examples; s-value reaching over 250). The resulting chiral compounds could be transformed into other useful structures while maintaining their chirality.

Synthesis of optically active 5′-noraristeromycin: enzyme-catalysed kinetic resolution of 9-(4-hydroxycyclopent-2-enyl)purines

1993 ◽  
pp. 1717-1718 ◽  
Author(s):  
Valeria Merlo ◽  
Fiona J. Reece ◽  
Stanley M. Roberts ◽  
Mike Gregson ◽  
Richard Storer
Keyword(s):  
Kinetic Resolution ◽  
Optically Active
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