An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes

2018 ◽  
Vol 54 (23) ◽  
pp. 2870-2873 ◽  
Author(s):  
Bo Cao ◽  
Yin Wei ◽  
Min Shi
Keyword(s):  
Indole Derivatives ◽  
Diastereoselective Synthesis ◽  
Free Atmosphere ◽  
Catalyst Free ◽  
Wide Range

A catalyst-free atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes and alkynes was developed, which provided a wide range of cyclobuta- and cyclopenta[b]indole derivatives in good yields.

Synthesis of 1,2,3-Triazole-Fused Indole Derivatives via Copper-Catalyzed Cascade Reaction

Synthesis ◽  
2021 ◽  
Author(s):  
Fengtao Zhou ◽  
Qiuyu Zhang ◽  
Kashif Majeed ◽  
Bangjie Liu
Keyword(s):  
Quantum Efficiency ◽  
Photophysical Properties ◽  
Cascade Reaction ◽  
Tandem Reaction ◽  
Indole Derivatives ◽  
Wide Range

AbstractA copper-catalyzed tandem reaction has been developed for the synthesis of 1,2,3-triazole-fused indole derivatives. This protocol allowed us to access a wide range of 1,2,3-triazole-fused indole derivatives in moderate to excellent yields. The 1,2,3-triazole-fused indole derivatives emit blue and greenish light when excited at 365 nm. The products were further explored for their quantum efficiency and photophysical properties.

One-pot, catalyst-free synthesis of novel dihydropyrano[2,3-e]indole derivatives

2021 ◽  
Vol 33 ◽  
pp. 100693
Author(s):  
Visarapu Malathi ◽  
Shantholla Shivani ◽  
K Bhaskar ◽  
Vinod G. Ugale ◽  
Pannala Padmaja ◽  
...  
Keyword(s):  
Indole Derivatives ◽  
One Pot ◽  
Catalyst Free

ChemInform Abstract: Diastereoselective Synthesis of N-Alkylated Octahydroacridines via a Catalyst-Free SNAr Approach.

ChemInform ◽  
2016 ◽  
Vol 47 (7) ◽  
pp. no-no
Author(s):  
Nagendra Prasad Muddala ◽  
Baskar Nammalwar ◽  
Subhashini Selvaraju ◽  
Richard A. Bunce
Keyword(s):  
Diastereoselective Synthesis ◽  
Catalyst Free

Catalyst-free coupling of indole derivatives with 3,4-dihydroisoquinoline and related compounds

2013 ◽  
Vol 54 (37) ◽  
pp. 5069-5071 ◽  
Author(s):  
István Szatmári ◽  
Judit Sas ◽  
Ferenc Fülöp
Keyword(s):  
Indole Derivatives ◽  
Catalyst Free ◽  
Related Compounds

scholarly journals A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates

2019 ◽  
Vol 15 ◽  
pp. 1523-1533 ◽  
Author(s):  
András György Németh ◽  
György Miklós Keserű ◽  
Péter Ábrányi-Balogh
Keyword(s):  
Elemental Sulfur ◽  
Building Blocks ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
Synthetic Procedure ◽  
Three Component Reaction ◽  
Wide Range ◽  
Organic Chemist ◽  
The One

A new multicomponent reaction has been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O-thiocarbamates and dithiocarbamates in moderate to good yields. The one-pot reaction cascade involves the formation of an isothiocyanate intermediate, thus a catalyst-free synthesis of isothiocyanates, as valuable building blocks from isocyanides and sulfur is proposed, as well. The synthetic procedure suits the demand of a modern organic chemist, as it tolerates a wide range of functional groups, it is atom economic and easily scalable.

Catalyst-Free Synthesis of Diastereomerically Pure 3-Sulfonyl­azetidin-2-ones via Microwave-Assisted Tandem Wolff Rearrangement–Staudinger Cycloaddition

Synthesis ◽  
2020 ◽  
Author(s):  
Mikhail Krasavin ◽  
Judith Synofzik ◽  
Olga Bakulina ◽  
Olga Balabas ◽  
Dmitry Dar’in
Keyword(s):  
Drug Design ◽  
Single Crystal ◽  
Wolff Rearrangement ◽  
X Ray ◽  
Design And Optimization ◽  
X Ray Crystallography ◽  
Microwave Assisted ◽  
Catalyst Free ◽  
Relative Stereochemistry ◽  
Wide Range

A wide range of α-diazo-β-ketosulfones have been applied to thermally promoted tandem Wolff rearrangement – Staudinger [2+2] cycloaddition with imines to give polysubstituted β-lactam sulfones. Dia­stereomerically pure syn-diastereomers were obtained in good yields and the relative stereochemistry was confirmed by single-crystal X-ray crystallography. These findings significantly expand the scope of this transformation, in contrast to substantial limitations reported previously. Moreover, this methodology enables flexible exploration of new substitution patterns around the privileged β-lactam core for drug design and optimization.

Mastication and Compounding of Natural Rubber in an Oxygen-Free Atmosphere

1950 ◽  
Vol 23 (3) ◽  
pp. 537-552 ◽  
Author(s):  
C. M. Blow ◽  
R. I. Wood
Keyword(s):  
Natural Rubber ◽  
Physical Properties ◽  
Research Association ◽  
High Modulus ◽  
Free Atmosphere ◽  
Wide Range ◽  
Viscosity Changes

Abstract Confirmation has been obtained that raw rubber when masticated in the absence of oxygen undergoes only a limited amount of breakdown; and it has been shown that two of the better known socalled “peptizers” or chemical plasticizers of rubber, viz., mercaptobenzothiazole and o-o′-dibenzamidodiphenyl disulfide, require oxygen to be effective. A range of pure-gum rubbers has been compounded under nitrogen, and the physical properties after vulcanization compared with corresponding air-compounded rubbers. Some types of acceleration give vulcanizates whose physical properties are very sensitive to changes in the viscosity of the unvulcanized stock, decrease in viscosity giving decreased modulus. Other types of acceleration, notably “boosted” combinations which give high modulus vulcanization, are insensitive to stock viscosity changes over a wide range. This work forms part of a program of research undertaken by the Board of the British Rubber Producers' Research Association.

Mitsunobu-initiated cascade cyclization of p-quinamines and 2-furanylmethanols: highly regio- and diastereoselective synthesis of functionalized hydrobenzo[c,d]indoles

2019 ◽  
Vol 17 (15) ◽  
pp. 3737-3740 ◽  
Author(s):  
Bo Cao ◽  
Yin Wei ◽  
Min Shi
Keyword(s):  
Indole Derivatives ◽  
Diastereoselective Synthesis ◽  
Cascade Cyclization

A Mitsunobu-initiated intermolecular cascade cyclization of p-quinamines and 2-furanylmethanol has been developed, giving hydrobenzo[c,d]indole derivatives in moderate to good yields with high regio- and diastereoselectivities.

A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines

2016 ◽  
Vol 18 (9) ◽  
pp. 2642-2646 ◽  
Author(s):  
Xiaofeng Zhang ◽  
Sanjun Zhi ◽  
Wei Wang ◽  
Shuai Liu ◽  
Jerry P. Jasinski ◽  
...  
Keyword(s):  
Click Reaction ◽  
Diastereoselective Synthesis ◽  
Polycyclic Compounds ◽  
Catalyst Free

A pot-economical synthesis involving two [3 + 2] cycloadditions for diastereoselective synthesis of novel triazolobenzodiazepine-containing polycyclic compounds.

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