Peptide-grafted dextran vectors for efficient and high-loading gene delivery

2019 ◽  
Vol 7 (4) ◽  
pp. 1543-1553 ◽  
Author(s):  
Yang Hu ◽  
Huifeng Wang ◽  
Haiqing Song ◽  
Megan Young ◽  
Yaqian Fan ◽  
...  
Keyword(s):  
Amino Acids ◽  
Gene Delivery ◽  
Building Blocks ◽  
Delivery Systems ◽  
High Loading ◽  
Structure And Properties ◽  
Unique Structure ◽  
Polymeric Gene Delivery

Among various polymeric gene delivery systems, peptide-based vectors demonstrate great potential owing to their unique structure and properties, including flexibility; however, there is insufficient molecular understanding of the role and properties of amino acids as building blocks in gene delivery.

scholarly journals Highly Branched Polymers Based on Poly(amino acid)s for Biomedical Application

Nanomaterials ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 1119
Author(s):  
Marisa Thompson ◽  
Carmen Scholz
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Glutamic Acid ◽  
Biomedical Applications ◽  
Large Scale ◽  
Biomedical Application ◽  
Building Blocks ◽  
Delivery Systems ◽  
Branched Polymers ◽  
Viral Gene

Polymers consisting of amino acid building blocks continue to receive consideration for biomedical applications. Since poly(amino acid)s are built from natural amino acids, the same building blocks proteins are made of, they are biocompatible, biodegradable and their degradation products are metabolizable. Some amino acids display a unique asymmetrical AB2 structure, which facilitates their ability to form branched structures. This review compares the three forms of highly branched polymeric structures: structurally highly organized dendrimers, dendrigrafts and the less organized, but readily synthesizable hyperbranched polymers. Their syntheses are reviewed and compared, methods of synthesis modulations are considered and variations on their traditional syntheses are shown. The potential use of highly branched polymers in the realm of biomedical applications is discussed, specifically their applications as delivery vehicles for genes and drugs and their use as antiviral compounds. Of the twenty essential amino acids, L-lysine, L-glutamic acid, and L-aspartic acid are asymmetrical AB2 molecules, but the bulk of the research into highly branched poly(amino acid)s has focused on the polycationic poly(L-lysine) with a lesser extent on poly(L-glutamic acid). Hence, the majority of potential applications lies in delivery systems for nucleic acids and this review examines and compares how these three types of highly branched polymers function as non-viral gene delivery vectors. When considering drug delivery systems, the small size of these highly branched polymers is advantageous for the delivery of inhalable drug. Even though highly branched polymers, in particular dendrimers, have been studied for more than 40 years for the delivery of genes and drugs, they have not translated in large scale into the clinic except for promising antiviral applications that have been commercialized.

scholarly journals Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3002
Author(s):  
Simge Er ◽  
Ushna Laraib ◽  
Rabia Arshad ◽  
Saman Sargazi ◽  
Abbas Rahdar ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Amino Acids ◽  
Amino Acid ◽  
Gene Delivery ◽  
Cost Effective ◽  
Delivery Systems ◽  
Drug Molecules ◽  
Or Gene ◽  
Gold Nanoislands ◽  
Proteins And Peptides

Over various scientific fields in biochemistry, amino acids have been highlighted in research works. Protein, peptide- and amino acid-based drug delivery systems have proficiently transformed nanotechnology via immense flexibility in their features for attaching various drug molecules and biodegradable polymers. In this regard, novel nanostructures including carbon nanotubes, electrospun carbon nanofibers, gold nanoislands, and metal-based nanoparticles have been introduced as nanosensors for accurate detection of these organic compounds. These nanostructures can bind the biological receptor to the sensor surface and increase the surface area of the working electrode, significantly enhancing the biosensor performance. Interestingly, protein-based nanocarriers have also emerged as useful drug and gene delivery platforms. This is important since, despite recent advancements, there are still biological barriers and other obstacles limiting gene and drug delivery efficacy. Currently available strategies for gene therapy are not cost-effective, and they do not deliver the genetic cargo effectively to target sites. With rapid advancements in nanotechnology, novel gene delivery systems are introduced as nonviral vectors such as protein, peptide, and amino acid-based nanostructures. These nano-based delivery platforms can be tailored into functional transformation using proteins and peptides ligands based nanocarriers, usually overexpressed in the specified diseases. The purpose of this review is to shed light on traditional and nanotechnology-based methods to detect amino acids, peptides, and proteins. Furthermore, new insights into the potential of amino protein-based nanoassemblies for targeted drug delivery or gene transfer are presented.

Impact of the nature, size and chain topologies of carbohydrate–phosphorylcholine polymeric gene delivery systems

Biomaterials ◽  
2012 ◽  
Vol 33 (31) ◽  
pp. 7858-7870 ◽  
Author(s):  
Marya Ahmed ◽  
Manraj Jawanda ◽  
Kazuhiko Ishihara ◽  
Ravin Narain
Keyword(s):  
Gene Delivery ◽  
Delivery Systems ◽  
Polymeric Gene Delivery

Recent Progress in Polymeric Gene Delivery Systems

2003 ◽  
Vol 20 (4) ◽  
pp. 249-293 ◽  
Author(s):  
Khursheed Anwer ◽  
B. G. Rhee ◽  
Sanjeev Kumar Mendiratta
Keyword(s):  
Gene Delivery ◽  
Recent Progress ◽  
Delivery Systems ◽  
Polymeric Gene Delivery
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