Clickable PEG hydrogel microspheres as building blocks for 3D bioprinting

2019 ◽  
Vol 7 (3) ◽  
pp. 1179-1187 ◽  
Author(s):  
Shangjing Xin ◽  
David Chimene ◽  
Jay E. Garza ◽  
Akhilesh K. Gaharwar ◽  
Daniel L. Alge
Keyword(s):  
Ethylene Glycol ◽  
Building Blocks ◽  
3D Bioprinting ◽  
Complex Cell ◽  
Poly Ethylene Glycol ◽  
3D Printed ◽  
Poly Ethylene ◽  
Hydrogel Microspheres

Clickable poly(ethylene glycol) hydrogel microspheres can be 3D printed and photochemically annealed to produce complex cell-laden structures.

scholarly journals Tailoring Atomoxetine Release Rate from DLP 3D-Printed Tablets Using Artificial Neural Networks: Influence of Tablet Thickness and Drug Loading

Molecules ◽  
2020 ◽  
Vol 26 (1) ◽  
pp. 111
Author(s):  
Gordana Stanojević ◽  
Djordje Medarević ◽  
Ivana Adamov ◽  
Nikola Pešić ◽  
Jovana Kovačević ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Release Rate ◽  
Drug Loading ◽  
Prolonged Release ◽  
Cylindrical Shape ◽  
Poly Ethylene Glycol ◽  
Scanning Calorimetry ◽  
3D Printed ◽  
Artificial Neural ◽  
Poly Ethylene

Various three-dimensional printing (3DP) technologies have been investigated so far in relation to their potential to produce customizable medicines and medical devices. The aim of this study was to examine the possibility of tailoring drug release rates from immediate to prolonged release by varying the tablet thickness and the drug loading, as well as to develop artificial neural network (ANN) predictive models for atomoxetine (ATH) release rate from DLP 3D-printed tablets. Photoreactive mixtures were comprised of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) 400 in a constant ratio of 3:1, water, photoinitiator and ATH as a model drug whose content was varied from 5% to 20% (w/w). Designed 3D models of cylindrical shape tablets were of constant diameter, but different thickness. A series of tablets with doses ranging from 2.06 mg to 37.48 mg, exhibiting immediate- and modified-release profiles were successfully fabricated, confirming the potential of this technology in manufacturing dosage forms on demand, with the possibility to adjust the dose and release behavior by varying drug loading and dimensions of tablets. DSC (differential scanning calorimetry), XRPD (X-ray powder diffraction) and microscopic analysis showed that ATH remained in a crystalline form in tablets, while FTIR spectroscopy confirmed that no interactions occurred between ATH and polymers.

scholarly journals A Non-Cytotoxic Resin for Micro-Stereolithography for Cell Cultures of HUVECs

Micromachines ◽  
2020 ◽  
Vol 11 (3) ◽  
pp. 246 ◽  
Author(s):  
Max Männel ◽  
Carolin Fischer ◽  
Julian Thiele
Keyword(s):  
Cell Culture ◽  
Ethylene Glycol ◽  
Umbilical Vein ◽  
Polymer Materials ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
3D Printed ◽  
Poly Ethylene ◽  
The Impact

Three-dimensional (3D) printing of microfluidic devices continuously replaces conventional fabrication methods. A versatile tool for achieving microscopic feature sizes and short process times is micro-stereolithography (µSL). However, common resins for µSL lack biocompatibility and are cytotoxic. This work focuses on developing new photo-curable resins as a basis for µSL fabrication of polymer materials and surfaces for cell culture. Different acrylate- and methacrylate-based compositions are screened for material characteristics including wettability, surface roughness, and swelling behavior. For further understanding, the impact of photo-absorber and photo-initiator on the cytotoxicity of 3D-printed substrates is studied. Cell culture experiments with human umbilical vein endothelial cells (HUVECs) in standard polystyrene vessels are compared to 3D-printed parts made from our library of homemade resins. Among these, after optimizing material composition and post-processing, we identify selected mixtures of poly(ethylene glycol) diacrylate (PEGDA) and poly(ethylene glycol) methyl ethyl methacrylate (PEGMEMA) as most suitable to allow for fabricating cell culture platforms that retain both the viability and proliferation of HUVECs. Next, our PEGDA/PEGMEMA resins will be further optimized regarding minimal feature size and cell adhesion to fabricate microscopic (microfluidic) cell culture platforms, e.g., for studying vascularization of HUVECs in vitro.

3D bioprinting of oligo(poly[ethylene glycol] fumarate) for bone and nerve tissue engineering

2020 ◽  
Vol 109 (1) ◽  
pp. 6-17
Author(s):  
Xifeng Liu ◽  
Bipin Gaihre ◽  
Matthew N. George ◽  
A. Lee Miller ◽  
Haocheng Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Nerve Tissue ◽  
3D Bioprinting ◽  
Poly Ethylene Glycol ◽  
Nerve Tissue Engineering ◽  
Poly Ethylene

Photonic Hydrogels with Poly(ethylene glycol) Derivative Colloidal Spheres as Building Blocks

2008 ◽  
Vol 41 (24) ◽  
pp. 9508-9512 ◽  
Author(s):  
Tong Cai ◽  
Guonan Wang ◽  
Samuel Thompson ◽  
Manuel Marquez ◽  
Zhibing Hu
Keyword(s):  
Ethylene Glycol ◽  
Building Blocks ◽  
Poly Ethylene Glycol ◽  
Colloidal Spheres ◽  
Poly Ethylene

Functional PEG building blocks via copolymerization of ethylene carbonate and tert-butyl glycidyl ether

2016 ◽  
Vol 7 (31) ◽  
pp. 5050-5059 ◽  
Author(s):  
G. Kapiti ◽  
H. Keul ◽  
M. Möller
Keyword(s):  
Ethylene Oxide ◽  
Ethylene Glycol ◽  
Ethylene Carbonate ◽  
Glycidyl Ether ◽  
Building Blocks ◽  
Poly Ethylene Glycol ◽  
Tert Butyl ◽  
Poly Ethylene ◽  
Butyl Glycidyl Ether

Functional poly(ethylene glycol) building blocks were synthesized with ethylene carbonate as a new source for ethylene oxide repeating units.

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