Mussel-inspired copolymer-coated polypropylene mesh with anti-adhesion efficiency for abdominal wall defect repair

2019 ◽  
Vol 7 (4) ◽  
pp. 1323-1334 ◽  
Author(s):  
Wanjun Hu ◽  
Shenglin Lu ◽  
Zhihang Zhang ◽  
Long Zhu ◽  
Yazhou Wen ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Abdominal Wall Defect ◽  
Poly Ethylene Glycol ◽  
Wall Defect ◽  
Defect Repair ◽  
Adhesion Efficiency ◽  
Poly Ethylene

Construction of anti-adhesive polypropylene meshes through the in situ copolymerization grafting of poly(ethylene glycol) methacrylate and dopamine methacrylamide.

Assembled anti-adhesion polypropylene mesh with self-fixable and degradable in situ mussel-inspired hydrogel coating for abdominal wall defect repair

2018 ◽  
Vol 6 (11) ◽  
pp. 3030-3041 ◽  
Author(s):  
Wanjun Hu ◽  
Zhigang Zhang ◽  
Shenglin Lu ◽  
Tianzhu Zhang ◽  
Naizhen Zhou ◽  
...  
Keyword(s):  
Abdominal Wall ◽  
Polypropylene Mesh ◽  
Abdominal Wall Defect ◽  
Wall Defect ◽  
Defect Repair ◽  
Hydrogel Coating

Construction of assembled anti-adhesion polypropylene mesh through in situ coating with self-fixable and degradable hydrogels.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

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