Thermosensitive drug-loading system based on copper sulfide nanoparticles for combined photothermal therapy and chemotherapy in vivo

2018 ◽  
Vol 6 (12) ◽  
pp. 3219-3230 ◽  
Author(s):  
Zhenwei Yuan ◽  
Sisi Qu ◽  
Yuanyuan He ◽  
Yue Xu ◽  
Li Liang ◽  
...  
Keyword(s):  
Phase Change ◽  
Phase Change Material ◽  
Copper Sulfide ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
Physiological Conditions ◽  
Loading System ◽  
Change Material

A phase-change material was used to design CuS-DOX-MBA@PCM nanoparticles, which could release the drug quickly in physiological conditions.

scholarly journals Hierarchical Drug Release Designed Au @PDA-PEG-MTX NPs for Targeted Delivery to Breast Cancer with Combined Photothermal-chemotherapy

2021 ◽  
Author(s):  
Wen Li ◽  
Zhiwen Cao ◽  
Liuchunyang Yu ◽  
Qingcai Huang ◽  
Dongjie Zhu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Release ◽  
Fluorescence Imaging ◽  
Targeted Delivery ◽  
Photothermal Therapy ◽  
Drug Loading ◽  
In Vivo Studies ◽  
Deep Penetration ◽  
Loading System

Abstract Breast cancer (BC) is the frequently diagnosed cancer and one of the deadliest causes of cancer-related death with a severe survival rate. Methotrexate (MTX) is an anti-tumor drug used in the treatment of BC. The poor dispersion in water and toxic side effects limit its clinical application. Gold nanoparticles (AuNPs), due to their specific structures and unique biological and physiochemical properties, have emerged as attractive candidates as vehicles for tumor targeting, bio-imaging and therapy. An innovative nano drug-loading system (Au @PDA-PEG-MTX NPs) was prepared for targeted treatment of BC. Au @PDA-PEG-MTX NPs under near infra-red region (NIR) irradiation showed effective photothermal therapy against MDA-MB-231 human BC cells growth in vitro by inducing apoptosis through triggering reactive oxygen species (ROS) overproduction and generating excessive heat. In vivo studies revealed that Au @PDA-PEG-MTX NPs under NIR irradiation showed deep penetration and cancer-targeted fluorescence imaging application and strong photothermal therapy against BC xenograft growth in vivo by induction of apoptosis. Analysis of histopathology, cellular uptake, cytotoxicity assay, apoptosis experiment indicated that Au @PDA-PEG-MTX NPs had a good therapeutic effect with high biocompatibility and less side effect. This Au NPs drug-loading system achieved specific BC targeting ability by surface decoration of MTX, NIR laser irradiation for fluorescence imaging and combined photothermal-chemotherapy as well as pH- and NIR- triggered hierarchical drug release.

scholarly journals Robotic Multi-Probe-Single-Actuator Inchworm Neural Microdrive

2020 ◽  
Author(s):  
R. D. Smith ◽  
I. Kolb ◽  
S. Tanaka ◽  
A. K. Lee ◽  
T. D. Harris ◽  
...  
Keyword(s):  
Phase Change ◽  
Phase Change Material ◽  
Piezo Actuator ◽  
Weight Restrictions ◽  
Ca1 Region ◽  
Resistive Heater ◽  
Significant Size ◽  
Change Material ◽  
Recording Electrodes

AbstractElectrophysiology is one of the major experimental techniques used in neuroscience. The favorable spatial and temporal resolution as well as the increasingly larger site counts of brain recording electrodes contribute to the popularity and importance of electrophysiology in neuroscience. Such electrodes are typically mechanically placed in the brain to perform acute or chronic freely moving animal measurements. The micro positioners currently used for such tasks employ a single translator per independent probe being placed into the targeted brain region, leading to significant size and weight restrictions. To overcome this limitation, we have developed a miniature robotic multi-probe neural microdrive that utilizes novel phase-change-material-filled resistive heater micro-grippers. The microscopic dimensions, gentle gripping action, independent electronic actuation control, and high packing density of the grippers allow for micrometer-precision independent positioning of multiple arbitrarily shaped parallel neural electrodes with only a single piezo actuator in an inchworm motor configuration. This multi-probe-single-actuator design allows for significant size and weight reduction, as well as remote control and potential automation of the microdrive. We demonstrate accurate placement of multiple independent recording electrodes into the CA1 region of the rat hippocampus in vivo in acute and chronic settings. Thus, our robotic neural microdrive technology is applicable towards basic neuroscience and clinical studies, as well as other multi-probe or multi-sensor micro-positioning applications.One Sentence SummaryMiniature robotic multi-probe single-actuator microdrive utilizing phase change material based micro-grippers.

NUMERICAL STUDY OF A SOLAR GREENHOUSE DRYER WITH A PHASE-CHANGE MATERIAL AS AN ENERGY STORAGE MEDIUM

2018 ◽  
Vol 49 (6) ◽  
pp. 509-528 ◽  
Author(s):  
Orawan Aumporn ◽  
Belkacem Zeghmati ◽  
Xavier Chesneau ◽  
Serm Janjai
Keyword(s):  
Energy Storage ◽  
Phase Change ◽  
Phase Change Material ◽  
Numerical Study ◽  
Storage Medium ◽  
Solar Greenhouse ◽  
Change Material

CONTROL OF HEAT RELEASE ENERGY DURING HEATING FROM SOLID-SOLID PHASE CHANGE MATERIAL

2018 ◽  
Author(s):  
Ryohei Gotoh ◽  
Tsuyoshi Totani ◽  
Masashi Wakita ◽  
Harunori Nagata
Keyword(s):  
Phase Change ◽  
Heat Release ◽  
Phase Change Material ◽  
Solid Phase ◽  
Change Material
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