Anti-biofouling therapeutic nanoparticles with removable shell and highly efficient internalization by cancer cells

2019 ◽  
Vol 7 (1) ◽  
pp. 336-346
Author(s):  
Dong Chen ◽  
Huangyong Jiang ◽  
Dongbo Guo ◽  
Wumaier Yasen ◽  
Junping Ao ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cellular Internalization ◽  
Highly Efficient

We fabricated a novel nanomedicine possessing both anti-biofouling feature and relatively high cellular internalization.

Highly efficient production of anti-HER2 scFv antibody variant for targeting breast cancer cells

2011 ◽  
Vol 91 (3) ◽  
pp. 613-621 ◽  
Author(s):  
Silvia Sommaruga ◽  
Alessio Lombardi ◽  
Agnese Salvadè ◽  
Serena Mazzucchelli ◽  
Fabio Corsi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Scfv Antibody ◽  
Efficient Production ◽  
Highly Efficient

The importance of cellular internalization of antibody-targeted carbon nanotubes in the photothermal ablation of breast cancer cells

2011 ◽  
Vol 22 (9) ◽  
pp. 095101 ◽  
Author(s):  
Radu Marches ◽  
Carole Mikoryak ◽  
Ru-Hung Wang ◽  
Paul Pantano ◽  
Rockford K Draper ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbon Nanotubes ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cellular Internalization ◽  
Photothermal Ablation

Enhanced Cytotoxicity and Cellular Internalization of Hemocompatible Curcumin Loaded Pluronic Linolenate Micelles in Cancer Cells

2014 ◽  
Vol 2 (1) ◽  
pp. 36-51 ◽  
Author(s):  
Radhika Raveendran ◽  
C. K. S. Pillai ◽  
G. S. Bhuvaneshwar ◽  
Chandra P. Sharma
Keyword(s):  
Cancer Cells ◽  
Cellular Internalization

Glimpse into Cellular Internalization and Intracellular Trafficking of Lipid-Based Nanoparticles in Cancer Cells

2021 ◽  
Vol 21 ◽  
Author(s):  
Elham Kamalkazemi ◽  
Fereydoon Abedi - Gaballu ◽  
Tala Farid Mohammad Hosseini ◽  
Ali Mohammadi ◽  
Behzad Mansoori ◽  
...  
Keyword(s):  
Particle Size ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Cellular Internalization ◽  
Intracellular Accumulation ◽  
Coated Nanoparticles ◽  
Cargo Delivery ◽  
Anti Cancer ◽  
Intracellular Fate

: Lipid-based nanoparticles as drug delivery carriers have been mainly used for delivery of anti-cancer therapeutic agents. Lipid-based nanoparticles, due to their smaller particle size and similarity to cell membranes, are readily internalized into cancer cells. Interestingly, cancer cells also overexpress receptors for specific ligands including folic acid, hyaluronic acid, and transferrin on their surface. This allows the use of these ligands for surface modification of the lipid-based nanoparticle. These modifications then allow the specific recognition of these ligand-coated nanoparticles by their receptors on cancer cells allowing the targeted gradual intracellular accumulation of the functionalized nanoplatforms. These interactions could eventually enhance the internalization of desired drugs via increasing ligand-receptor mediated cellular uptake of the nanoplatforms. The cellular internalization of the nanoplatforms also varies and depends on their physicochemical properties including particle size, zeta potential, and shape. The cellular uptake is also influenced by the types of ligand internalization pathway utilized by cells such as phagocytosis, macropinocytosis, and multiple endocytosis pathways. In this review, we will classify and discuss lipid based nanoparticles engineered to express specific ligands, and are recognized by their receptors on cancer cell, and their cellular internalization pathways. Moreover, the intracellular fate of nanoparticles decorated with specific ligands and the best internalization pathways (caveolae mediated endocytosis) for safe cargo delivery will be discussed.

scholarly journals Starch–borate–graphene oxide nanocomposites as highly efficient targeted antitumor drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (115) ◽  
pp. 94855-94858 ◽  
Author(s):  
Rumei Cheng ◽  
Shengju Ou ◽  
Yexu Bu ◽  
Xuan Li ◽  
Xiaohong Liu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Cancer Cells ◽  
Antitumor Drugs ◽  
Normal Cells ◽  
Highly Efficient

Novel antitumor drugs, compatible with normal cells but highly toxic against cancer cells, were prepared from starch–borate–graphene oxide (SBG) nanocomposites.

scholarly journals Highly efficient colorimetric detection of target cancer cells utilizing superior catalytic activity of graphene oxide–magnetic-platinum nanohybrids

Nanoscale ◽  
2014 ◽  
Vol 6 (3) ◽  
pp. 1529-1536 ◽  
Author(s):  
Moon Il Kim ◽  
Min Su Kim ◽  
Min-Ah Woo ◽  
Youngjin Ye ◽  
Kyoung Suk Kang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Catalytic Activity ◽  
Cancer Cells ◽  
Colorimetric Detection ◽  
Highly Efficient ◽  
Target Cancer

Rhipsalis (Cactaceae)-like Hierarchical Structure Based Microfluidic Chip for Highly Efficient Isolation of Rare Cancer Cells

2016 ◽  
Vol 8 (49) ◽  
pp. 33457-33463 ◽  
Author(s):  
Shuangqian Yan ◽  
Xian Zhang ◽  
Xiaofang Dai ◽  
Xiaojun Feng ◽  
Wei Du ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Hierarchical Structure ◽  
Microfluidic Chip ◽  
Rare Cancer ◽  
Highly Efficient
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