A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

2018 ◽  
Vol 6 (10) ◽  
pp. 2566-2570 ◽  
Author(s):  
Hong Kee Kim ◽  
Soo Hyeon Lee ◽  
Boo Yong Lee ◽  
Sung Jin Kim ◽  
Chang Yub Sung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Comparative Study ◽  
Vinyl Pyrrolidone ◽  
Peptide Drug ◽  
Pharmacokinetic Properties ◽  
Poly Vinyl Pyrrolidone

We studied the role of the additives trehalose and poly(vinyl pyrrolidone) in the physical and pharmacokinetic properties of peptide drug incorporated microneedles.

Poly (vinyl pyrrolidone)-lipid based hybrid nanoparticles for anti viral drug delivery

2018 ◽  
Vol 210 ◽  
pp. 82-89 ◽  
Author(s):  
K.S. Joshy ◽  
S. Snigdha ◽  
George Anne ◽  
Kalarikkal Nandakumar ◽  
Pothen Laly. A. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Vinyl Pyrrolidone ◽  
Hybrid Nanoparticles ◽  
Poly Vinyl Pyrrolidone

The HA-incorporated nanostructure of a peptide–drug amphiphile for targeted anticancer drug delivery

2016 ◽  
Vol 52 (32) ◽  
pp. 5637-5640 ◽  
Author(s):  
Huyeon Choi ◽  
M. T. Jeena ◽  
L. Palanikumar ◽  
Yoojeong Jeong ◽  
Sooham Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Anticancer Drug ◽  
Peptide Drug ◽  
Anticancer Drug Delivery

We demonstrate targeted anticancer drug delivery using transformable nanostructures of the complex of hyaluronic acid (HA) and KCK–CPT, a prodrug amphiphile composed of camptothecin (CPT) and tripeptide (KCK).

Role of pumice particles in the thermal, electrical and mechanical properties of poly(vinyl alcohol)/poly(vinyl pyrrolidone) composites

2016 ◽  
Vol 126 (2) ◽  
pp. 511-519 ◽  
Author(s):  
Manammel Thankappan Ramesan ◽  
Ankita George ◽  
Panniyamvelli Jayakrishnan ◽  
Gopalannair Kalaprasad
Keyword(s):  
Mechanical Properties ◽  
Vinyl Alcohol ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Poly Vinyl Pyrrolidone

scholarly journals A role of free silanol groups of nanosilica surface in interaction with poly(vinyl pyrrolidone)

2018 ◽  
Vol 72 (2) ◽  
pp. 51 ◽  
Author(s):  
Olga Voronina ◽  
Maria Malysheva ◽  
Liudmyla Nosach ◽  
Eugeny Voronin ◽  
Vladimir Gun’ko ◽  
...  
Keyword(s):  
Specific Surface ◽  
Surface Area ◽  
Specific Surface Area ◽  
Crucial Role ◽  
Vinyl Pyrrolidone ◽  
Initial Amount ◽  
Silanol Groups ◽  
Adsorption Monolayer ◽  
Poly Vinyl Pyrrolidone

In this work, a role of the number of free silanol groups at a nanosilica surface (specific surface area S<sub>BET</sub> = 250 m<sup>2</sup>/g, initial amount of silanols α<sub>ОН</sub> = 0.60-0.62 mmol/g) was analyzed in interaction with poly(vinyl pyrrolidone) (PVP) vs. the degree (Q<sub>TMS</sub>) of silica hydrophobization by hexamethyldisilazane at 100 <sup>o</sup>C. The value of Q<sub>TMS</sub> was 0.07, 0.42, 0.67, 0.81, 0.82, and 1.0. Adsorption of PVP onto a nanosilica surface was carried out from a water and water-ethanol (1:1) solutions of the polymer. It was shown that free silanol groups play a crucial role in the adsorption of poly(vinyl pyrrolidone). The value of the maximal adsorption (monolayer capacity) on completely hydrophobic nanosilica surface is approximately by 6.5 times lower than that for unmodified nanosilica

scholarly journals Electrospun PVP/PVA Nanofiber Mat as a Novel Potential Transdermal Drug-Delivery System for Buprenorphine: A Solution Needed for Pain Management

2021 ◽  
Vol 11 (6) ◽  
pp. 2779
Author(s):  
Fatemeh Rahmani ◽  
Hakimeh Ziyadi ◽  
Mitra Baghali ◽  
Hongrong Luo ◽  
Seeram Ramakrishna
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Transdermal Drug Delivery ◽  
Electrospinning Process ◽  
Vinyl Pyrrolidone ◽  
Transdermal Drug Delivery System ◽  
Ft Ir ◽  
Poly Vinyl Pyrrolidone ◽  
Nanofiber Mats ◽  
Contact Angle Analysis

Over the past several decades, the formulation of novel nanofiber-based drug-delivery systems has been a frequent focus of scientists around the world. Aiming to introduce a novel nanofibrous transdermal drug-delivery system to treat pain, the nanofiber mats of buprenorphine-loaded poly (vinyl pyrrolidone) (Bup/PVP) and buprenorphine-loaded poly(vinyl alcohol)/poly(vinyl pyrrolidone) (Bup/PVP/PVA) were successfully fabricated by the electrospinning process for transdermal drug delivery. Similarly, PVP and PVP/PVA nanofibers were fabricated in the same conditions for comparison. The viscosity and electrical conductivity of all electrospinning solutions were measured, and nanofiber mats were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared (FT-IR) spectroscopy and contact angle analysis. The conductivity of PVP and PVP/PVA solutions showed a considerable increase by the addition of buprenorphine due to the polarity of buprenorphine. SEM images showed a smooth, fine and porous nanofibrous structure without any adhesion or knot for all of the samples. The contact angle analysis showed the increased hydrophilicity and wettability of PVP/PVA and Bup/PVP/PVA nanofibers compared to PVP and Bup/PVP nanofibers which can be attributed to the addition of PVA. Attenuated total reflectance (ATR) FT-IR results confirmed that the electrospinning process did not affect the chemical integrity of the drug. For the modification of the drug release rate, the cross-linking of nanofiber mats was carried out using glutaraldehyde. Drug release measurements using high-performance liquid chromatography (HPLC) analysis demonstrated that Bup/PVP/PVA nanofibers exhibited better physical and chemical properties compared to Bup/PVP. Furthermore, the cross-linking of nanofibers led to an increase in drug release time. Thus, the novel buprenorphine-loaded nanofibers can be efficient biomaterial patches for transdermal delivery against pain improving carrier retention and providing a controlled release of the drug.

scholarly journals Analysis of electrical measurements oncadmium chloridedoped PVA-PVP blend

2017 ◽  
Vol 16 (1) ◽  
pp. 45-65 ◽  
Author(s):  
Basavarajeshwari M Baraker ◽  
Blaise Lobo
Keyword(s):  
Charge Carriers ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Electrical Measurements ◽  
Temperature Dependent ◽  
Mobility Of Charge Carriers ◽  
Solution Casting Method ◽  
Poly Vinyl Pyrrolidone ◽  
Electrical Data

Films of Poly(vinyl alcohol) (PVA) - Poly(vinyl pyrrolidone) (PVP) blend, doped withcadmium chloride (CdCl2) from 0.5 wt% up to 40 wt% andprepared by solution casting method,were studied using temperature dependent direct current (DC)electrical measurements. The DC electrical data were analyzed using Variable Range Hopping (VRH) modelin the temperature range varying from 303K up to 318K. The Mott parameters are determined. The study of time evolution of current passing through the sample, when a constant voltage is applied across it reveals that ions are the majority charge carriers, but the role of electrons in charge transport cannot be neglected. The activation energy (Ea) for mobility of charge carriers has been calculated from VRHand Arrhenius models.

Enhanced Thermo-Mechanical Properties of Poly(vinyl alcohol)/Poly(vinyl pyrrolidone) Polymer Blended with Nanographene

2020 ◽  
Vol 16 ◽  
Author(s):  
Seenaa Hussein ◽  
Alaa Abd-Elnaiem ◽  
Nadia Ali
Keyword(s):  
Thermal Stability ◽  
Vinyl Alcohol ◽  
Nanocomposite Films ◽  
Vinyl Pyrrolidone ◽  
Poly Vinyl Alcohol ◽  
Good Thermal Stability ◽  
Blend Morphology ◽  
Poly Vinyl Pyrrolidone ◽  
Blend Polymer

Background: The addition of nanofillers to polymers for enhanced performance is delivering more interesting applications for aerospace, aeronautic industries, and other numerous nano-technical applications. Objective: The aim was therefore to examine the role of graphene nanopowder on the thermal stability and conductivity of the poly(vinyl alcohol)/poly(vinyl pyrrolidone) (PVA/PVP) polymer nanocomposites. Methods: In this work, graphene nanofillers were incorporated into the PVA/PVP polymer blended by solution mixing for the preparation of nanocomposite films. Results: Results showed that; increasing graphene ratio improved thermal conductivity up to 330%, moreover enhancing hardness shore A up to 16.3% compared to pure PVA/PVP blend polymer. TGA analysis confirmed that the PVA/PVP and graphene network showed good thermal stability. Conclusion: From the present findings, it is proved that PVA/PVP blends have profound effects on thermal stability that cannot be attained by using individual counterparts. The property of the nanocomposite depends on the host blend, morphology, and interfacial characteristics.

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