In vivotailor-made protein corona of a prodrug-based nanoassembly fabricated by redox dual-sensitive paclitaxel prodrug for the superselective treatment of breast cancer

2018 ◽  
Vol 6 (9) ◽  
pp. 2360-2374 ◽  
Author(s):  
Dong Zhang ◽  
Jincheng Yang ◽  
Jibin Guan ◽  
Bin Yang ◽  
Shenwu Zhang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Effect ◽  
Protein Corona ◽  
Albumin Binding ◽  
Endogenous Albumin

A PTX-maleimide prodrug nanosystem with enhanced endogenous albumin binding and potent antitumor effect is presented.

Antitumor effect and potentiation of cytotoxic drug activity of a dual topoisomerase inhibitor on breast cancer

2019 ◽  
Author(s):  
I Flörkemeier ◽  
TN Steinhauer ◽  
MT van Mackelenbergh ◽  
B Clement ◽  
DO Bauerschlag
Keyword(s):  
Breast Cancer ◽  
Antitumor Effect ◽  
Cytotoxic Drug ◽  
Drug Activity ◽  
Topoisomerase Inhibitor

ANTITUMOR EFFECT OF SUNITINIB AND BORTEZOMIB ON BREAST CANCER CELL LINE IN VITRO

2017 ◽  
Vol 63 (1) ◽  
pp. 141-145
Author(s):  
Yuliya Khochenkova ◽  
Eliso Solomko ◽  
Oksana Ryabaya ◽  
Yevgeniya Stepanova ◽  
Dmitriy Khochenkov
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Antitumor Effect ◽  
Cancer Cell Lines ◽  
Breast Cancer Cell Lines ◽  
Actual Problem

The discovery for effective combinations of anticancer drugs for treatment for breast cancer is the actual problem in the experimental chemotherapy. In this paper we conducted a study of antitumor effect of the combination of sunitinib and bortezomib against MDA-MB-231 and SKBR-3 breast cancer cell lines in vitro. We found that bortezomib in non-toxic concentrations can potentiate the antitumor activity of sunitinib. MDA-MB-231 cell line has showed great sensitivity to the combination of bortezomib and sunitinib in vitro. Bortezomib and sunitinib caused reduced expression of receptor tyrosine kinases VEGFR1, VEGFR2, PDGFRa, PDGFRß and c-Kit on HER2- and HER2+ breast cancer cell lines

Antitumor Effect of Mesenchymal Stem Cells from Murine in Breast Cancer in Female Rats

2018 ◽  
Vol 35 (1) ◽  
pp. 369-374
Author(s):  
Omayma A.R. AbouZaid ◽  
Laila A Rashed ◽  
S. M. El-Sonbaty ◽  
Aboel-Ftouh A. I
Keyword(s):  
Breast Cancer ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Antitumor Effect ◽  
Female Rats

scholarly journals Uptake of Upconverting Nanoparticles by Breast Cancer Cells: Surface Coating versus the Protein Corona

2021 ◽  
Author(s):  
Evelina Voronovic ◽  
Artiom Skripka ◽  
Greta Jarockyte ◽  
Marija Ger ◽  
Dalius Kuciauskas ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Surface Coating ◽  
Breast Cancer Cells ◽  
Protein Corona

Application of digital holographic tumography in antitumor effect of cantharides complex on 4T1 breast cancer cells

2021 ◽  
Vol 60 (12) ◽  
pp. 3365
Author(s):  
Chen-Wen Lu ◽  
Andrey V. Belashov ◽  
Anna A. Zhikhoreva ◽  
Irina V. Semenova ◽  
Chau-Jern Cheng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Antitumor Effect ◽  
4T1 Breast Cancer

scholarly journals Selenium inhibits growth of trastuzumab-resistant human breast cancer cells via downregulation of Akt and beclin-1

PLoS ONE ◽  
2021 ◽  
Vol 16 (9) ◽  
pp. e0257298
Author(s):  
Joohyun Woo ◽  
Jong Bin Kim ◽  
Taeeun Cho ◽  
Eun Hye Yoo ◽  
Byung-In Moon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Cell Lines ◽  
Combination Treatment ◽  
Breast Cancer Cells ◽  
Antitumor Effect ◽  
Beclin 1 ◽  
Her2 Positive ◽  
Phosphorylated Akt ◽  
Positive Breast Cancer

The response rate to treatment with trastuzumab (Tz), a recombinant humanized anti-HER2 monoclonal antibody, is only 12–34% despite demonstrated effectiveness on improving the survival of patients with HER2-positive breast cancers. Selenium has an antitumor effect against cancer cells and can play a cytoprotective role on normal cells. This study investigated the effect of selenium on HER2-positive breast cancer cells and the mechanism in relation to the response of the cells to Tz. HER2-positive breast cancer cell lines, SK-BR-3 as trastuzumab-sensitive cells, and JIMT-1 as Tz-resistant cells were treated with Tz and sodium selenite (selenite). Cell survival rates and expression of Her2, Akt, and autophagy-related proteins, including LC3B and beclin 1, in both cell lines 72 h after treatment were evaluated. Significant cell death was induced at different concentrations of selenite in both cell lines. A combined effect of selenite and Tz at 72 h was similar to or significantly greater than each drug alone. The expression of phosphorylated Akt (p-Akt) was decreased in JIMT-1 after combination treatment compared to that after only Tz treatment, while p-Akt expression was increased in SK-BR-3. The expression of beclin1 increased particularly in JIMT-1 after only Tz treatment and was downregulated by combination treatment. These results showed that combination of Tz and selenite had an antitumor effect in Tz-resistant breast cancer cells through downregulation of phosphorylated Akt and beclin1-related autophagy. Selenite might be a potent drug to treat Tz-resistant breast cancer by several mechanisms.

scholarly journals Sulforaphane: Expected to Become a Novel Antitumor Compound

2020 ◽  
Vol 28 (4) ◽  
pp. 439-446 ◽  
Author(s):  
Geting Wu ◽  
Yuanliang Yan ◽  
Yangying Zhou ◽  
Yumei Duan ◽  
Shuangshuang Zeng ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Antitumor Effect ◽  
Malignant Tumors ◽  
Inhibitory Effects ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Alternative Systems ◽  
Antitumor Compound ◽  
Functional Mechanisms ◽  
Potential Biomarkers

Natural products are becoming increasingly popular in a variety of traditional, complementary, and alternative systems due to their potency and slight side effects. Natural compounds have been shown to be effective against many human diseases, especially cancers. Sulforaphane (SFE) is a traditional Chinese herbal medicine. In recent years, an increasing number of studies have been conducted to evaluate the antitumor effect of SFE. The roles of SFE in cancers are mainly through the regulation of potential biomarkers to activate or inhibit related signaling pathways. SFE has exhibited promising inhibitory effects on breast cancer, lung cancer, liver cancer, and other malignant tumors. In this review, we summarized the reports on the activity and functional mechanisms of SFE in cancer treatment and explored the efficacy and toxicity of SFE.

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