Self-assembled, bivalent aptamers on graphene oxide as an efficient anticoagulant

2018 ◽  
Vol 6 (7) ◽  
pp. 1882-1891 ◽  
Author(s):  
Pei-Xin Lai ◽  
Ju-Yi Mao ◽  
Binesh Unnikrishnan ◽  
Han-Wei Chu ◽  
Chien-Wei Wu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Self Assembly ◽  
Anticoagulant Activity ◽  
Cost Effective ◽  
Self Assembled

Self-assembly of a bivalent thrombin-binding aptamer on graphene oxide that is easy to prepare, cost-effective, and highly biocompatible and shows in vivo anticoagulant activity.

scholarly journals Microribbons composed of directionally self-assembled nanoflakes as highly stretchable ionic neural electrodes

2020 ◽  
Vol 117 (26) ◽  
pp. 14667-14675 ◽  
Author(s):  
Mingchao Zhang ◽  
Rui Guo ◽  
Ke Chen ◽  
Yiliang Wang ◽  
Jiali Niu ◽  
...  
Keyword(s):  
Self Assembly ◽  
Structural Variation ◽  
Three Dimensional ◽  
Biological Tissues ◽  
Superior Performance ◽  
Ionic Conductors ◽  
Structural Variations ◽  
Neural Electrodes ◽  
Self Assembled

Many natural materials possess built-in structural variation, endowing them with superior performance. However, it is challenging to realize programmable structural variation in self-assembled synthetic materials since self-assembly processes usually generate uniform and ordered structures. Here, we report the formation of asymmetric microribbons composed of directionally self-assembled two-dimensional nanoflakes in a polymeric matrix during three-dimensional direct-ink printing. The printed ribbons with embedded structural variations show site-specific variance in their mechanical properties. Remarkably, the ribbons can spontaneously transform into ultrastretchable springs with controllable helical architecture upon stimulation. Such springs also exhibit superior nanoscale transport behavior as nanofluidic ionic conductors under even ultralarge tensile strains (>1,000%). Furthermore, to show possible real-world uses of such materials, we demonstrate in vivo neural recording and stimulation using such springs in a bullfrog animal model. Thus, such springs can be used as neural electrodes compatible with soft and dynamic biological tissues.

scholarly journals Carrier-free, self-assembled pure drug nanorods composed of 10-hydroxycamptothecin and chlorin e6 for combinatorial chemo-photodynamic antitumor therapy in vivo

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14347-14356 ◽  
Author(s):  
Yan Wen ◽  
Wei Zhang ◽  
Ningqiang Gong ◽  
Yi-Feng Wang ◽  
Hong-Bo Guo ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Self Assembly ◽  
Chlorin E6 ◽  
Antitumor Therapy ◽  
Carrier Free ◽  
Pure Drug ◽  
Self Assembled

Carrier-free nanodrug HCPT/Ce6 NRs were prepared through a simple self-assembly approach for chemo-photodynamic combination therapy of tumors in vivo.

scholarly journals Construction and Characterizations of Antibacterial Surfaces Based on Self-Assembled Monolayer of Antimicrobial Peptides (Pac-525) Derivatives on Gold

Coatings ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 1014
Author(s):  
Zijiao Zhang ◽  
Ni Kou ◽  
Weilong Ye ◽  
Shuo Wang ◽  
Jiaju Lu ◽  
...  
Keyword(s):  
Antimicrobial Peptides ◽  
Self Assembly ◽  
The Self ◽  
Self Assembled Monolayer ◽  
E Coli ◽  
Antimicrobial Efficiency ◽  
Gold Substrates ◽  
Self Assembled ◽  
Antibacterial Surfaces

Background: Infection that is related to implanted biomaterials is a serious issue in the clinic. Antimicrobial peptides (AMPs) have been considered as an ideal alternative to traditional antibiotic drugs, for the treatment of infections, while some problems, such as aggregation and protein hydrolysis, are still the dominant concerns that compromise their antimicrobial efficiency in vivo. Methods: In this study, antimicrobial peptides underwent self-assembly on gold substrates, forming good antibacterial surfaces, with stable antibacterial behavior. The antimicrobial ability of AMPs grafted on the surfaces, with or without glycine spaces or a primer layer, was evaluated. Results: Specifically, three Pac-525 derivatives, namely, Ac-CGn-KWRRWVRWI-NH2 (n = 0, 2, or 6) were covalently grafted onto gold substrates via the self-assembling process for inhibiting the growth of Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli). Furthermore, the alkanethiols HS(CH)10SH were firstly self-assembled into monolayers, as a primer layer (SAM-SH) for the secondary self-assembly of Pac-525 derivatives, to effectively enhance the bactericidal performance of the grafted AMPs. The -(CH)10-S-S-G6Pac derivative was highly effective against S. aureus and E. coli, and reduced the viable amount of E. coli and S. aureus to 0.4% and 33.2%, respectively, after 24 h of contact. In addition, the immobilized AMPs showed good biocompatibility, promoting bone marrow stem cell proliferation. Conclusion: the self-assembled monolayers of the Pac-525 derivatives have great potential as a novel therapeutic method for the treatment of implanted biomaterial infections.

scholarly journals Improving the Wear Life of a-C:H Film in High Vacuum by Self-Assembled Reduced Graphene Oxide Layers

Nanomaterials ◽  
2019 ◽  
Vol 9 (12) ◽  
pp. 1733 ◽  
Author(s):  
Hui Song ◽  
Gang Chen ◽  
Jie Chen ◽  
Hongxuan Li ◽  
Li Ji ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Reduced Graphene Oxide ◽  
Self Assembly ◽  
High Vacuum ◽  
Carbon Film ◽  
Friction Reduction ◽  
Friction Behavior ◽  
Assembly Method ◽  
Reduced Graphene ◽  
Self Assembled

As an energy-efficient surface modification method, self-assembly has been the subject of extensive research. However, its application on carbon film has been rarely reported. In the present work, a novel self-assembled reduced graphene oxide (RGO) was prepared on a-C:H film by a controllable self-assembly method, and the friction behavior of the RGO/a-C:H film was investigated under vacuum environment. Interestingly, the RGO/a-C:H film exhibited significant improvement of anti-wear ability in vacuum conditions under a high applied load of 5 N. As expected, the synergy lubrication effect of the RGO layer and a-C:H film should account for the excellent friction reduction and anti-wear ability of a RGO/a-C:H multilayer film.

scholarly journals Peptide Nanomaterials for Drug Delivery Applications

2020 ◽  
Vol 21 (4) ◽  
pp. 401-412 ◽  
Author(s):  
Sreekanth Pentlavalli ◽  
Sophie Coulter ◽  
Garry Laverty
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Diverse Range ◽  
Drug Molecules ◽  
Sustained Drug Delivery ◽  
Self Assembling ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
Self Assembled

Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.

Spin Coating Mediated Morphology Modulation in Self Assembly of Peptides

Nanoscale ◽  
2021 ◽  
Author(s):  
Nandini Bhandaru ◽  
Gagandeep Kaur ◽  
Apurva Panjla ◽  
Sandeep Verma
Keyword(s):  
Self Assembly ◽  
Spin Coating ◽  
Material Science ◽  
Fundamental Importance ◽  
Self Assembled

Controlling the morphology and nanostructure of self-assembled peptide molecules is of fundamental importance to chemistry and material science due to their bioactivity in both in vivo and in vitro settings,...

Scrolling up graphene oxide nanosheets assisted by self-assembled monolayers of alkanethiols

Nanoscale ◽  
2017 ◽  
Vol 9 (28) ◽  
pp. 9997-10001 ◽  
Author(s):  
Lin Wang ◽  
Peng Yang ◽  
Yang Liu ◽  
Xiangru Fang ◽  
Xiaotong Shi ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Self Assembly ◽  
The Self ◽  
Self Assembled Monolayers ◽  
Gold Substrate ◽  
Graphene Oxide Nanosheets ◽  
High Quality ◽  
Humidity Sensing ◽  
Assembled Monolayers ◽  
Self Assembled

The fabrication of high-quality nanoscrolls of GO on a gold substrate assisted by the self-assembly of alkanethiol monolayers for humidity sensing.

Disulfide modified self-assembly of lipopeptides with arginine-rich periphery achieve excellent gene transfection efficiency at relatively low nitrogen to phosphorus ratios

2017 ◽  
Vol 5 (7) ◽  
pp. 1482-1497 ◽  
Author(s):  
Xiaobing Chen ◽  
Jun Yang ◽  
Hong Liang ◽  
Qian Jiang ◽  
Bowen Ke ◽  
...  
Keyword(s):  
Self Assembly ◽  
Disulfide Bonds ◽  
Transfection Efficiency ◽  
Gene Transfection ◽  
Viral Envelope ◽  
Self Assembled ◽  
Low Nitrogen

Self-assembled lipopeptides, with viral envelope, capsid-inspired arginine-rich periphery and disulfide bonds, achieve excellent transfectionin vitroandin vivo.

scholarly journals Fabrication of Hollow Silica Particles Using a Self-Assembled Polyethylene Granule as a Template

2018 ◽  
Vol 2018 ◽  
pp. 1-9
Author(s):  
Sang-Yul Park ◽  
Hyo-Sun Kim ◽  
Jeseung Yoo ◽  
Young-Soo Seo
Keyword(s):  
Self Assembly ◽  
Cost Effective ◽  
Acid Value ◽  
Silica Coating ◽  
Silica Particles ◽  
The Self ◽  
Hollow Silica ◽  
Practical Applications ◽  
Self Assembled ◽  
Hollow Silica Particles

We developed a novel method preparing nonspherical hollow silica particles (HSP) using a micron-sized granule self-assembled from partially oxidized PE wax. The morphology of the granule was closely investigated in terms of concentration and acid value of PE wax and cooling rate. Due to the oxidized unit in PE wax, magnetic nanoparticle was incorporated into the granule during the self-assembly, and silica was coated on the granule surface via the self-assembly. Silica-coating condition was studied by varying water content and reaction time. After the PE wax was removed by calcination, nonspherical HSP or magnetic HSP was obtained. This cost-effective HSP is expected to be useful for practical applications.

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