Taxol-modified collagen scaffold implantation promotes functional recovery after long-distance spinal cord complete transection in canines

2018 ◽  
Vol 6 (5) ◽  
pp. 1099-1108 ◽  
Author(s):  
Wen Yin ◽  
Xing Li ◽  
Yannan Zhao ◽  
Jun Tan ◽  
Shuyu Wu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axon Regeneration ◽  
Collagen Scaffold ◽  
Acute Spinal Cord Injury ◽  
Long Distance ◽  
Complete Transection ◽  
Cord Injury ◽  
Promising Treatment

LOCS + Taxol implantation, a promising treatment for acute spinal cord injury, promotes endogenous neurogenesis, axon regeneration and locomotion recovery.

scholarly journals Nitrous Oxide Impairs Axon Regeneration after Nervous System Injury in Male Rats

2019 ◽  
Vol 131 (5) ◽  
pp. 1063-1076
Author(s):  
Krista J. Stewart ◽  
Bermans J. Iskandar ◽  
Brenton M. Meier ◽  
Elias B. Rizk ◽  
Nithya Hariharan ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nervous System ◽  
Nitrous Oxide ◽  
Folic Acid ◽  
Functional Recovery ◽  
Axon Regeneration ◽  
Retinal Ganglion ◽  
Cord Injury

Abstract Editor’s Perspective What We Already Know about This Topic What This Article Tells Us That Is New Background Nitrous oxide can induce neurotoxicity. The authors hypothesized that exposure to nitrous oxide impairs axonal regeneration and functional recovery after central nervous system injury. Methods The consequences of single and serial in vivo nitrous oxide exposures on axon regeneration in four experimental male rat models of nervous system injury were measured: in vitro axon regeneration in cell culture after in vivo nitrous oxide administration, in vivo axon regeneration after sharp spinal cord injury, in vivo axon regeneration after sharp optic nerve injury, and in vivo functional recovery after blunt contusion spinal cord injury. Results In vitro axon regeneration 48 h after a single in vivo 70% N2O exposure is less than half that in the absence of nitrous oxide (mean ± SD, 478 ± 275 um; n = 48) versus 210 ± 152 um (n = 48; P < 0.0001). A single exposure to 80% N2O inhibits the beneficial effects of folic acid on in vivo axonal regeneration after sharp spinal cord injury (13.4 ± 7.1% regenerating neurons [n = 12] vs. 0.6 ± 0.7% regenerating neurons [n = 4], P = 0.004). Serial 80% N2O administration reverses the benefit of folic acid on in vivo retinal ganglion cell axon regeneration after sharp optic nerve injury (1277 ± 180 regenerating retinal ganglion cells [n = 7] vs. 895 ± 164 regenerating retinal ganglion cells [n = 7], P = 0.005). Serial 80% N2O exposures reverses the benefit of folic acid on in vivo functional recovery after blunt spinal cord contusion (estimate for fixed effects ± standard error of the estimate: folic acid 5.60 ± 0.54 [n = 9] vs. folic acid + 80% N2O 5.19 ± 0.62 [n = 7], P < 0.0001). Conclusions These data indicate that nitrous oxide can impair the ability of central nervous system neurons to regenerate axons after sharp and blunt trauma.

A modified collagen scaffold facilitates endogenous neurogenesis for acute spinal cord injury repair

2017 ◽  
Vol 51 ◽  
pp. 304-316 ◽  
Author(s):  
Caixia Fan ◽  
Xing Li ◽  
Zhifeng Xiao ◽  
Yannan Zhao ◽  
Hui Liang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Collagen Scaffold ◽  
Acute Spinal Cord Injury ◽  
Injury Repair ◽  
Cord Injury

scholarly journals Nogo-66 Receptor Prevents Raphespinal and Rubrospinal Axon Regeneration and Limits Functional Recovery from Spinal Cord Injury

Neuron ◽  
2004 ◽  
Vol 44 (3) ◽  
pp. 439-451 ◽  
Author(s):  
Ji-Eun Kim ◽  
Betty P. Liu ◽  
James H. Park ◽  
Stephen M. Strittmatter
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Functional Recovery ◽  
Axon Regeneration ◽  
Cord Injury
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