scholarly journals Synergistic effects of hyaluronate – epidermal growth factor conjugate patch on chronic wound healing

2018 ◽  
Vol 6 (5) ◽  
pp. 1020-1030 ◽  
Author(s):  
Yun Seop Kim ◽  
Dong Kyung Sung ◽  
Won Ho Kong ◽  
Hyemin Kim ◽  
Sei Kwang Hahn
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Synergistic Effects ◽  
Topical Delivery ◽  
Epidermal Growth

A HA–EGF conjugate patch was developed for the treatment of diabetic chronic wounds with advantages such as facilitating topical delivery and interaction with dual receptors, and alleviating the degradation of EGF.

Epidermal Growth Factor in Wound Healing: A Model for the Molecular Pathogenesis of Chronic Wounds

1997 ◽  
pp. 206-228 ◽  
Author(s):  
Roy W. Tarnuzzer ◽  
Shawn P. Macauley ◽  
Bruce A. Mast ◽  
Jane S. Gibson ◽  
Michael C. Stacey ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chronic Wounds ◽  
Molecular Pathogenesis ◽  
Epidermal Growth

scholarly journals Growth factor functionalized biomaterial for drug delivery and tissue regeneration

2017 ◽  
Vol 32 (6) ◽  
pp. 568-581 ◽  
Author(s):  
Alex Leonard ◽  
Piyush Koria
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Tissue Regeneration ◽  
Chronic Wounds ◽  
Biologically Active ◽  
Application Site ◽  
Epidermal Growth ◽  
And Migration

Elastin-like polypeptides are a class of naturally derived and non-immunogenic biomaterials that are widely used in drug delivery and tissue engineering. Elastin-like polypeptides undergo temperature-mediated inverse phase transitioning, which allows them to be purified in a relatively simple manner from bacterial expression hosts. Being able to genetically encode elastin-like polypeptides allows for the incorporation of bioactive peptides, thereby functionalizing them. Here, we report the synthesis of a biologically active epidermal growth factor–elastin-like polypeptide fusion protein that could aid in wound healing. Epidermal growth factor plays a crucial role in wound healing by inducing cell proliferation and migration. The use of exogenous epidermal growth factor has seen success in the treatment of acute wounds, but has seen relatively minimal success in chronic wounds because the method of delivery does not prevent it from diffusing away from the application site. Our data show that epidermal growth factor–elastin-like polypeptide retained the biological activity of epidermal growth factor and the phase transitioning property of elastin-like polypeptide. Furthermore, the ability of the epidermal growth factor–elastin-like polypeptide to self-assemble near physiological temperatures could allow for the formation of drug depots at the wound site and minimize diffusion, increasing the bioavailability of epidermal growth factor and enhancing tissue regeneration.

scholarly journals Recombinant Human Epidermal Growth Factor/Quatsome Nanoconjugates: A Robust Topical Delivery System for Complex Wound Healing (Adv. Therap. 6/2021)

2021 ◽  
Vol 4 (6) ◽  
pp. 2170011
Author(s):  
Lidia Ferrer‐Tasies ◽  
Hector Santana ◽  
Ingrid Cabrera‐Puig ◽  
Elisabet González‐Mira ◽  
Lídia Ballell‐Hosa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Delivery System ◽  
Topical Delivery ◽  
Human Epidermal Growth Factor ◽  
Complex Wound ◽  
Epidermal Growth

scholarly journals Effect of moist dressing, collagen sheet dressing and epidermal growth factor in healing of chronic wounds

2017 ◽  
Vol 4 (8) ◽  
pp. 2594
Author(s):  
Sheelchandra Jain ◽  
Darshana S. Tote ◽  
Gaurav Kolte ◽  
Suhas Jajoo ◽  
Sachin Tote
Keyword(s):  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Cost Effective ◽  
Functional Results ◽  
Treated Group ◽  
Controlled Study ◽  
Collagen Group ◽  
Epidermal Growth

Background: Surgical literature is full of innumerable solutions to the problems of wound healing and it speaks of itself that the problem is not so simple and straight forward to tackle with. The aim of the present study was to compare three modalities moist saline dressing, collagen sheet dressing and epidermal growth factor in early epithelization and healing of chronic wounds. to study the effect of various dressing modalities on epithelization of chronic wound in terms of time required for healing and the quality of scar it forms, the functional results both early and late, post-healing morbidity and complications and the practicality and the cost involved in using these modalities.Methods: Prospective randomized controlled study. Study including chronic wound cases admit to AVBRH Sawangi over period of 3 years.Results: Reduction in size of wound by 70-100% was found highest in Epigrof group. In Epigrof treated group 88% of wounds healed within 3 weeks while 80% in collagen group and 56% in moist dressing group it. Collagen dressing is the most cost effective of the three whereas Epigrof was most costly due to the initial cost of purchase. The scar quality was satisfactory in 19 of Epigrof group and 17 of the collagen sheet group and 15 of the moist dressing group.Conclusions: Epidermal growth factor is superior in epithelization, collagen is the next best local applicant, but collagen sheet is more cost effective than Epigrof and non-adherent dressings.

scholarly journals Recombinant Human Epidermal Growth Factor/Quatsome Nanoconjugates: A Robust Topical Delivery System for Complex Wound Healing

2021 ◽  
pp. 2000260
Author(s):  
Lidia Ferrer‐Tasies ◽  
Hector Santana ◽  
Ingrid Cabrera‐Puig ◽  
Elisabet González‐Mira ◽  
Lídia Ballell‐Hosa ◽  
...  
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Delivery System ◽  
Topical Delivery ◽  
Human Epidermal Growth Factor ◽  
Complex Wound ◽  
Epidermal Growth

Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing : Pilot , double‐blind , randomized clinical controlled trial

2021 ◽  
Author(s):  
Bianca Campos Oliveira ◽  
Beatriz Guitton Renaud Baptista Oliveira ◽  
Gabriela Deutsch ◽  
Fernanda Soares Pessanha ◽  
Selma Rodrigues Castilho
Keyword(s):  
Wound Healing ◽  
Growth Factor ◽  
Epidermal Growth Factor ◽  
Controlled Trial ◽  
Diabetic Patients ◽  
Double Blind ◽  
Epidermal Growth
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