Mesoporous Pd@Pt core–shell nanoparticles supported on multi-walled carbon nanotubes as a sensing platform: application in simultaneous electrochemical detection of anticancer drugs doxorubicin and dasatinib

2019 ◽  
Vol 11 (4) ◽  
pp. 443-453 ◽  
Author(s):  
Pramod K. Kalambate ◽  
Yankai Li ◽  
Yue Shen ◽  
Yunhui Huang
Keyword(s):  
Carbon Nanotubes ◽  
Anticancer Drugs ◽  
Electrochemical Detection ◽  
Simultaneous Detection ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Sensing Platform ◽  
Multi Walled Carbon Nanotubes ◽  
Core Shell Nanoparticles ◽  
Walled Carbon Nanotubes

A novel electrochemical sensor based on Pd@Pt/MWCNT composite for simultaneous detection of doxorubicin and dasatinib.

scholarly journals Gold-Platinum Core-Shell Nanoparticles with Thiolated Polyaniline and Multi-Walled Carbon Nanotubes for the Simultaneous Voltammetric Determination of Six Drug Molecules

Chemosensors ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 24
Author(s):  
Shaopei Li ◽  
Jiayun Zhou ◽  
Meissam Noroozifar ◽  
Kagan Kerman
Keyword(s):  
Carbon Nanotubes ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Drug Molecules ◽  
Redox Active ◽  
Multi Walled Carbon Nanotubes ◽  
Simultaneous Voltammetric Determination ◽  
Core Shell Nanoparticles ◽  
Walled Carbon Nanotubes

In this proof-of-concept study, a novel nanocomposite of the thiolated polyaniline (tPANI), multi-walled carbon nanotubes (MWCNTs) and gold–platinum core-shell nanoparticles (Au@Pt) (tPANI-Au@Pt-MWCNT) was synthesized and utilized to modify a glassy carbon electrode (GCE) for simultaneous voltammetric determination of six over-the-counter (OTC) drug molecules: ascorbic acid (AA), levodopa (LD), acetaminophen (AC), diclofenac (DI), acetylsalicylic acid (AS) and caffeine (CA). The nanocomposite (tPANI-Au@Pt-MWCNT) was characterized with transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), and X-ray photoelectron spectroscopy (XPS). Using the sensor (GCE-tPANI-Au@Pt-MWCNT) in connection with differential pulse voltammetry (DPV), the calibration plots were determined to be linear up to 570.0, 60.0, 60.0, 115.0, 375.0 and 520.0 µM with limit of detection (LOD) of 1.5, 0.25, 0.15, 0.2, 2.0, and 5.0 µM for AA, LD, AC, DI, AS and CA, respectively. The nanocomposite-modified sensor was successfully used for the determination of these redox-active compounds in commercially available OTC products such as energy drinks, cream and tablets with good recovery yields ranging from 95.48 ± 0.53 to 104.1 ± 1.63%. We envisage that the electrochemical sensor provides a promising platform for future applications towards the detection of redox-active drug molecules in pharmaceutical quality control studies and forensic investigations.

scholarly journals Simultaneous electrochemical detection of levodapa, paracetamol and l-tyrosine based on multi-walled carbon nanotubes

RSC Advances ◽  
2020 ◽  
Vol 10 (24) ◽  
pp. 14218-14224 ◽  
Author(s):  
Zai-Yu Li ◽  
Dan-Yang Gao ◽  
Zhi-Yong Wu ◽  
Shuang Zhao
Keyword(s):  
Carbon Nanotubes ◽  
Electrochemical Sensor ◽  
Electrochemical Detection ◽  
Simultaneous Detection ◽  
Linear Range ◽  
Good Reproducibility ◽  
Wide Linear Range ◽  
Multi Walled Carbon Nanotubes ◽  
Walled Carbon Nanotubes

A novel electrochemical sensor for the simultaneous detection of levodopa, paracetamol and l-tyrosine was developed based on multi-walled carbon nanotubes. The sensor has the merits of wide linear range, good selectivity and good reproducibility.

Selective Sensing Platform Utilizing Graphitized Multi-Walled Carbon Nanotubes for Monitoring of Ondansetron and Paracetamol

2020 ◽  
Vol 16 ◽  
Author(s):  
Biljana Nigović ◽  
Iva Šimunić ◽  
Ana Mornar
Keyword(s):  
Carbon Nanotubes ◽  
Cation Exchange ◽  
Supporting Electrolyte ◽  
Polymer Concentration ◽  
Fixed Dose ◽  
Sensing Platform ◽  
Multi Walled Carbon Nanotubes ◽  
Electroanalytical Method ◽  
Walled Carbon Nanotubes

Background: Ondansetron and paracetamol are often co-administrated to prevent and treat nausea and vomiting caused by anaesthesia and to control of postoperative pain. In addition, ondansetron is used as the first-line antiemetic in paracetamol overdose. Therefore, selective and sensitive method for their simultaneous analysis is of a great importance. The electroanalytical methods are highly sensitive and offer many possibilities for new sensor platform design. However, at present, no electroanalytical method for simultaneous determination of these drugs has been proposed. Objective: The aim of this study was to develop a novel nanosensor for selective monitoring of ondansetron and paracetamol in pharmaceutical and biological samples without expensive and time-consuming pretreatments. Methods: The graphitized multi-walled carbon nanotubes embedded in a cation exchange polymer matrix was selected, among various surface functionalizations evaluated, to design novel sensor. Based on its excellent sensing performance, the first electroanalytical method was developed for rapid concurrent determination of investigated drugs. Results: The scanning electron microscopy study showed interlinked nanoporous network structure and highly enlarged active surface. The developed sensor facilitated electron transfer in the oxidation of both drugs and tremendously enhanced the adsorption capacity for ondasetron, thus exhibiting significant increase of drug responses and sensitivity. To obtain much sensitive response of investigated drugs the effect of pH values of supporting electrolyte, dispersed nanomaterial amount, the cation exchange polymer concentration, drop-casting volume of nanocomposite suspension, accumulation potential and deposition time on the peak current was evaluated. The developed electroanalytical method was validated and practical utility of the proposed nanosensor was tested. Conclusion: The developed sensor is promising sensing platform with a fast response time for analysis of ondansetron and paracetamol at very different concentration levels found in their fixed-dose combination and human serum sample after recommended daily doses showing its potential usage in pharmaceutical quality control and clinical research.

Catalyzed growth of oriented carbon nanotubes using Fe–organosilicon core–shell nanoparticles

2008 ◽  
Vol 40 (7) ◽  
pp. 2252-2256 ◽  
Author(s):  
C.T. Fleaca ◽  
I. Morjan ◽  
R. Alexandrescu ◽  
F. Dumitrache ◽  
I. Soare ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles
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