An aptamer based voltammetric biosensor for endotoxins using a functionalized graphene and molybdenum disulfide composite as a new nanocarrier

The Analyst ◽  
2019 ◽  
Vol 144 (4) ◽  
pp. 1253-1259 ◽  
Author(s):  
Yonghua Yuan ◽  
Linlin Li ◽  
Min Zhao ◽  
Jing Zhou ◽  
Zhihui Chen ◽  
...  
Keyword(s):  
Molybdenum Disulfide ◽  
Functionalized Graphene ◽  
Label Free ◽  
Highly Sensitive

This work describes a label-free aptasensor for highly sensitive endotoxin detection using a functionalized graphene and molybdenum disulfide composite for amplification.

Label-free fluorescent catalytic biosensor for highly sensitive and selective detection of the ferrous ion in water samples using a layered molybdenum disulfide nanozyme coupled with an advanced chemometric model

The Analyst ◽  
2016 ◽  
Vol 141 (5) ◽  
pp. 1822-1829 ◽  
Author(s):  
Jie Hu ◽  
Qianfen Zhuang ◽  
Yong Wang ◽  
Yongnian Ni
Keyword(s):  
Molybdenum Disulfide ◽  
Water Samples ◽  
Catalytic Effect ◽  
Ferrous Ion ◽  
Selective Detection ◽  
Label Free ◽  
Highly Sensitive

The synergistically enhanced catalytic effect of a Fe2+/molybdenum disulfide (MoS2) nanosheet was exploited to construct a nanozyme biosensor for Fe2+.

scholarly journals Sequence-Independent DNA Adsorption on Few-Layered Oxygen-Functionalized Graphene Electrodes: An Electrochemical Study for Biosensing Application

Biosensors ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 273
Author(s):  
Narges Asefifeyzabadi ◽  
Torrey E. Holland ◽  
Poopalasingam Sivakumar ◽  
Saikat Talapatra ◽  
Ishani M. Senanayake ◽  
...  
Keyword(s):  
Divalent Cations ◽  
Low Cost ◽  
Differential Pulse ◽  
Current Response ◽  
Functionalized Graphene ◽  
Label Free ◽  
Dna Adsorption ◽  
Redox Probe ◽  
Highly Sensitive ◽  
Electrochemical Charge Transfer

DNA is strongly adsorbed on oxidized graphene surfaces in the presence of divalent cations. Here, we studied the effect of DNA adsorption on electrochemical charge transfer at few-layered, oxygen-functionalized graphene (GOx) electrodes. DNA adsorption on the inkjet-printed GOx electrodes caused amplified current response from ferro/ferricyanide redox probe at concentration range 1 aM–10 nM in differential pulse voltammetry. We studied a number of variables that may affect the current response of the interface: sequence type, conformation, concentration, length, and ionic strength. Later, we showed a proof-of-concept DNA biosensing application, which is free from chemical immobilization of the probe and sensitive at attomolar concentration regime. We propose that GOx electrodes promise a low-cost solution to fabricate a highly sensitive platform for label-free and chemisorption-free DNA biosensing.

Highly sensitive electrochemical detection of circulating tumor DNA based on thin-layer MoS2/graphene composites

RSC Advances ◽  
2016 ◽  
Vol 6 (27) ◽  
pp. 22673-22678 ◽  
Author(s):  
Yilan Chu ◽  
Bin Cai ◽  
Ye Ma ◽  
Minggang Zhao ◽  
Zhizhen Ye ◽  
...  
Keyword(s):  
Thin Layer ◽  
Electrochemical Sensor ◽  
Molybdenum Disulfide ◽  
Electrochemical Detection ◽  
Ultrasonic Method ◽  
Hydrothermal Process ◽  
Circulating Tumor Dna ◽  
Label Free ◽  
Highly Sensitive ◽  
Tumor Dna

By integrating thin-layer molybdenum disulfide (MoS2) and graphene through a hydrothermal process and an ultrasonic method, a label-free, amplification-free and ultrasensitive circulating tumor DNA electrochemical sensor was made.

scholarly journals Optical Monitoring of the Production Quality of Si-Nanoribbon Chips Intended for the Detection of ASD-Associated Oligonucleotides

Micromachines ◽  
2021 ◽  
Vol 12 (2) ◽  
pp. 147
Author(s):  
Kristina A. Malsagova ◽  
Tatyana O. Pleshakova ◽  
Vladimir P. Popov ◽  
Igor N. Kupriyanov ◽  
Rafael A. Galiullin ◽  
...  
Keyword(s):  
Production Quality ◽  
Autism Spectrum ◽  
Covalent Immobilization ◽  
Biological Macromolecules ◽  
Label Free ◽  
Raman Scattering Spectroscopy ◽  
Dna Oligonucleotides ◽  
Highly Sensitive ◽  
Highly Sensitive Detection

Gas-phase etching and optical lithography were employed for the fabrication of a silicon nanoribbon chip (Si-NR chip). The quality of the so-fabricated silicon nanoribbons (Si-NRs) was monitored by optical Raman scattering spectroscopy. It was demonstrated that the structures of the Si-NRs were virtually defect-free, meaning they could be used for highly sensitive detection of biological macromolecules. The Si-NR chips were then used for the highly sensitive nanoelectronics detection of DNA oligonucleotides (oDNAs), which represent synthetic analogs of 106a-5p microRNA (miR-106a-5p), associated with the development of autism spectrum disorders in children. The specificity of the analysis was attained by the sensitization of the Si-NR chip sur-face by covalent immobilization of oDNA probes, whose nucleotide sequence was complementary to the known sequence of miR-106a-5p. The use of the Si-NR chip was demonstrated to al-low for the rapid label-free real-time detection of oDNA at ultra-low (~10−17 M) concentrations.

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