scholarly journals Identification of the Al-binding proteins that account for aluminum neurotoxicity and transportin vivo

2018 ◽  
Vol 7 (1) ◽  
pp. 127-135 ◽  
Author(s):  
Dai Cheng ◽  
Xiaomei Wang ◽  
Yu Xi ◽  
Jiankang Cao ◽  
Weibo Jiang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Binding Proteins ◽  
Aluminum Neurotoxicity

Studies have shown that aluminum (Al) is the most abundant neurotoxic element on Earth, and is implicated in the pathogenesis of Alzheimer's disease (AD).

DT-03-02: Viewing neurodegeneration beyond the tangle: The role of RNA binding proteins in Alzheimer's disease

2013 ◽  
Vol 9 ◽  
pp. P847-P847
Author(s):  
Benjamin Wolozin ◽  
Tara Vanderweyde ◽  
Liqun Liu-Yesucevitz ◽  
Alpaslan Dedeoglu ◽  
Leonard Petrucelli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins

scholarly journals Aluminum Neurotoxicity — Potential Role in the Pathogenesis of Neurofibrillary Tangle Formation

1986 ◽  
Vol 13 (S4) ◽  
pp. 441-445 ◽  
Author(s):  
Daniel P. Perl ◽  
William W. Pendlebury
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurofibrillary Tangle ◽  
Bulk Analysis ◽  
Ongoing Research ◽  
Aluminum Salts ◽  
Neuronal Populations ◽  
Large Numbers ◽  
Aluminum Neurotoxicity

Abstract:Alzheimer's disease is a progressive neurodegenerative disease characterized neuropathologically by the development of large numbers of neurofibrillary tangles in certain neuronal populations of affected brains. This paper presents a review of the available evidence which suggests that aluminum is associated with Alzheimer's disease and specifically with the development of the neurofibrillary tangle. Aluminum salts innoculated into experimental animals produce neurofilamentous lesions which are similar, though not identical, to the neurofibrillary tangle of man. Although a few reports have suggested evidence of increased amounts of aluminum in the brains of Alzheimer's disease victims, such bulk analysis studies have been difficult to replicate. Using scanning electron microscopy with x-ray spectrometry, we have identified accumulations of aluminum in neurofibrillary tangle-bearing neurons of Alzheimer's disease. Similar accumulations have been identified in the neurofibrillary tangle-bearing neurons found in the brains of indigenous natives of Guam who suffer from parkinsonism with dementia and amyotrophic lateral sclerosis. This ongoing research still cannot ascribe a causal role of aluminum in the pathogenesis of neurofibrillary tangle formation; however, it does suggest that environmental factors may play an important part in the formation of this abnormality.

P2-124 PKC and ELAV-like mRNA binding proteins: a new cascade for memory trace formation and Alzheimer's disease

2004 ◽  
Vol 25 ◽  
pp. S260
Author(s):  
Marialaura Amadio ◽  
Alessandro Quattrone ◽  
Daniel L. Alkon ◽  
Marco Racchi ◽  
Stefano Govoni ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Binding Proteins ◽  
Memory Trace ◽  
Mrna Binding Proteins ◽  
Mrna Binding ◽  
Trace Formation

scholarly journals Calmodulin Binding Proteins and Alzheimer’s Disease: Biomarkers, Regulatory Enzymes and Receptors That Are Regulated by Calmodulin

2020 ◽  
Vol 21 (19) ◽  
pp. 7344 ◽  
Author(s):  
Danton H. O’Day
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Binding Proteins ◽  
Neurofibrillary Tangle ◽  
Long Term Potentiation ◽  
Central Function ◽  
Calmodulin Binding ◽  
Term Potentiation

The integral role of calmodulin in the amyloid pathway and neurofibrillary tangle formation in Alzheimer’s disease was first established leading to the “Calmodulin Hypothesis”. Continued research has extended our insight into the central function of the small calcium sensor and effector calmodulin and its target proteins in a multitude of other events associated with the onset and progression of this devastating neurodegenerative disease. Calmodulin’s involvement in the contrasting roles of calcium/CaM-dependent kinase II (CaMKII) and calcineurin (CaN) in long term potentiation and depression, respectively, and memory impairment and neurodegeneration are updated. The functions of the proposed neuronal biomarker neurogranin, a calmodulin binding protein also involved in long term potentiation and depression, is detailed. In addition, new discoveries into calmodulin’s role in regulating glutamate receptors (mGluR, NMDAR) are overviewed. The interplay between calmodulin and amyloid beta in the regulation of PMCA and ryanodine receptors are prime examples of how the buildup of classic biomarkers can underly the signs and symptoms of Alzheimer’s. The role of calmodulin in the function of stromal interaction molecule 2 (STIM2) and adenosine A2A receptor, two other proteins linked to neurodegenerative events, is discussed. Prior to concluding, an analysis of how targeting calmodulin and its binding proteins are viable routes for Alzheimer’s therapy is presented. In total, calmodulin and its binding proteins are further revealed to be central to the onset and progression of Alzheimer’s disease.

Aluminum Neurotoxicity and Alzheimer’s Disease

1995 ◽  
pp. 223-229 ◽  
Author(s):  
Sakae Yumoto ◽  
Shigeo Kakimi ◽  
Yoshiaki Ogawa ◽  
Hisao Nagai ◽  
Mineo Imamura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Aluminum Neurotoxicity

scholarly journals RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease

2018 ◽  
Vol 293 (28) ◽  
pp. 11047-11066 ◽  
Author(s):  
Isaac Bishof ◽  
Eric B. Dammer ◽  
Duc M. Duong ◽  
Sean R. Kundinger ◽  
Marla Gearing ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins

Coupling of human brain cerebral cortical α2-adrenoceptors to GTP-binding proteins in Alzheimer's disease

1991 ◽  
Vol 563 (1-2) ◽  
pp. 39-43 ◽  
Author(s):  
Cora O'Neill ◽  
Christopher J. Fowler ◽  
Birgitta Wiehager ◽  
Richard F. Cowburn ◽  
Irina Alafuzoff ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Human Brain ◽  
Binding Proteins ◽  
Α2 Adrenoceptors ◽  
Gtp Binding Proteins ◽  
Gtp Binding

O2-02-05: RNA-BINDING PROTEINS WITH MIXED CHARGE DOMAINS SELF-ASSEMBLE AND AGGREGATE IN ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_11) ◽  
pp. P612-P612
Author(s):  
Isaac J. Bishof ◽  
Eric B. Dammer ◽  
Duc Duong ◽  
Marla Gearing ◽  
James J. Lah ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Binding Proteins ◽  
Rna Binding ◽  
Rna Binding Proteins
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