scholarly journals Prenatal food restriction induces neurobehavioral abnormalities in adult female offspring rats and alters intrauterine programming

2018 ◽  
Vol 7 (2) ◽  
pp. 293-306 ◽  
Author(s):  
Bo He ◽  
Dan Xu ◽  
Chong Zhang ◽  
Li Zhang ◽  
Hui Wang
Keyword(s):  
Chronic Stress ◽  
Adult Female ◽  
High Fat Diet ◽  
Food Restriction ◽  
Female Offspring ◽  
High Fat ◽  
Intrauterine Programming

This research suggests the intrauterine mechanism underlying prenatal food restriction-induced neurobehavioral abnormalities in adult female offspring fed a post-weaning high-fat diet and chronic stress.

scholarly journals Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

2019 ◽  
Vol 10 (8) ◽  
pp. 4505-4521 ◽  
Author(s):  
Liyuan Zhou ◽  
Xinhua Xiao ◽  
Qian Zhang ◽  
Jia Zheng ◽  
Ming Li ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Adult Female ◽  
High Fat Diet ◽  
Female Offspring ◽  
Protective Effects ◽  
High Fat ◽  
Harmful Effects

Perinatal genistein intake mitigated the harmful effects of high-fat diet on metabolism in both dams and female offspring, and the protective effects were associated with the alterations in gut microbiota.

scholarly journals Prenatal food restriction induces poor-quality articular cartilage in female rat offspring fed a post-weaning high-fat diet and its intra-uterine programming mechanisms

2016 ◽  
Vol 116 (8) ◽  
pp. 1346-1355 ◽  
Author(s):  
Yang Tan ◽  
Yunpeng Wu ◽  
Qubo Ni ◽  
Yu Deng ◽  
Jing Li ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
High Fat Diet ◽  
Cholesterol Efflux ◽  
Food Restriction ◽  
Cholesterol Metabolism ◽  
Female Offspring ◽  
Poor Quality ◽  
Female Rat ◽  
High Fat

AbstractEpidemiological data show that osteoarthritis (OA) is significantly associated with lower birth weight, and that OA may be a type of fetal-originated adult disease. The present study aimed to investigate the prenatal food-restriction (PFR) effect on the quality of articular cartilage in female offspring to explore the underlying mechanisms of fetal-originated OA. Maternal rats were fed a restricted diet from gestational day (GD) 11 to 20 to induce intra-uterine growth retardation. Female fetuses and female adult offspring fed a post-weaning high-fat diet were killed at GD20 and postnatal week 24, respectively. Serum and knee cartilage samples from fetuses and adult female offspring were collected and examined for cholesterol metabolism and histology. Fetal serum corticosterone and insulin-like growth factor-1 (IGF-1) in the PFR group were lower than those of the control, but the serum cholesterol level was not changed. The lower expression of IGF-1 in the PFR group lasted into adulthood. The expression of extracellular matrix (ECM) genes, including type II collagen, aggrecan and cholesterol efflux genes including liver X receptor, were significantly induced, but the ATP-binding-cassette transporter A1 was unchanged. PFR could induce a reduction in ECM synthesis and impaired cholesterol efflux in female offspring, and eventually led to poor quality of articular cartilage and OA.

scholarly journals Prenatal ethanol exposure induces an intrauterine programming of enhanced sensitivity of the hypothalamic–pituitary–adrenal axis in female offspring rats fed with post-weaning high-fat diet

2015 ◽  
Vol 4 (5) ◽  
pp. 1238-1249 ◽  
Author(s):  
Juan Lu ◽  
Yinxian Wen ◽  
Li Zhang ◽  
Chong Zhang ◽  
Weihua Zhong ◽  
...  
Keyword(s):  
Hpa Axis ◽  
High Fat Diet ◽  
Female Offspring ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
High Fat ◽  
Hypothalamic Pituitary Adrenal ◽  
Enhanced Sensitivity ◽  
Pituitary Adrenal Axis ◽  
Intrauterine Programming

“Intrauterine programming” involved in the intrauterine origin of prenatal ethanol exposure induced enhanced sensitivity of the HPA axis in female offspring rats fed with high-fat diet.

scholarly journals Maternal high fat diet induces impaired polyunsaturated fatty acid synthesis in adult female offspring in rats

2011 ◽  
Vol 70 (OCE4) ◽  
Author(s):  
S. P. Hoile ◽  
N. A. Irvine ◽  
C. Kelsall ◽  
C. Torrens ◽  
K. A. Lillycrop ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Adult Female ◽  
Fatty Acid Synthesis ◽  
High Fat Diet ◽  
Acid Synthesis ◽  
Female Offspring ◽  
High Fat

scholarly journals Maternal High-Fat Diet During Pre-Conception and Gestation Predisposes Adult Female Offspring to Metabolic Dysfunction in Mice

2022 ◽  
Vol 12 ◽  
Author(s):  
Brian Akhaphong ◽  
Brigid Gregg ◽  
Doga Kumusoglu ◽  
Seokwon Jo ◽  
Kanakadurga Singer ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Adult Female ◽  
High Fat Diet ◽  
Female Offspring ◽  
Cell Fraction ◽  
Adult Offspring ◽  
High Fat ◽  
Normal Chow

The risk of obesity in adulthood is subject to programming in the womb. Maternal obesity contributes to programming of obesity and metabolic disease risk in the adult offspring. With the increasing prevalence of obesity in women of reproductive age there is a need to understand the ramifications of maternal high-fat diet (HFD) during pregnancy on offspring’s metabolic heath trajectory. In the present study, we determined the long-term metabolic outcomes on adult male and female offspring of dams fed with HFD during pregnancy. C57BL/6J dams were fed either Ctrl or 60% Kcal HFD for 4 weeks before and throughout pregnancy, and we tested glucose homeostasis in the adult offspring. Both Ctrl and HFD-dams displayed increased weight during pregnancy, but HFD-dams gained more weight than Ctrl-dams. Litter size and offspring birthweight were not different between HFD-dams or Ctrl-dams. A significant reduction in random blood glucose was evident in newborns from HFD-dams compared to Ctrl-dams. Islet morphology and alpha-cell fraction were normal but a reduction in beta-cell fraction was observed in newborns from HFD-dams compared to Ctrl-dams. During adulthood, male offspring of HFD-dams displayed comparable glucose tolerance under normal chow. Male offspring re-challenged with HFD displayed glucose intolerance transiently. Adult female offspring of HFD-dams demonstrated normal glucose tolerance but displayed increased insulin resistance relative to controls under normal chow diet. Moreover, adult female offspring of HFD-dams displayed increased insulin secretion in response to high-glucose treatment, but beta-cell mass were comparable between groups. Together, these data show that maternal HFD at pre-conception and during gestation predisposes the female offspring to insulin resistance in adulthood.

scholarly journals Prenatal nicotine exposure-induced intrauterine programming alteration increases the susceptibility of high-fat diet-induced non-alcoholic simple fatty liver in female adult offspring rats

2015 ◽  
Vol 4 (1) ◽  
pp. 112-120 ◽  
Author(s):  
Dan Xu ◽  
Jing Bai ◽  
Li Zhang ◽  
Lang Shen ◽  
Linlong Wang ◽  
...  
Keyword(s):  
Fatty Liver ◽  
High Fat Diet ◽  
Female Offspring ◽  
Adult Offspring ◽  
Nicotine Exposure ◽  
High Fat ◽  
Female Adult ◽  
Prenatal Nicotine Exposure ◽  
Prenatal Nicotine ◽  
Intrauterine Programming

“Two intrauterine programming”, involved in the intrauterine origin of high-fat diet-induced NAFL in female offspring rats, induced by prenatal nicotine exposure.

Effects of Maternal Flaxseed Supplementation on Female Offspring of Diabetic Rats in Serum Concentration of Glucose, Insulin, and Thyroid Hormones

2019 ◽  
Vol 89 (1-2) ◽  
pp. 45-54
Author(s):  
Akemi Suzuki ◽  
André Manoel Correia-Santos ◽  
Gabriela Câmara Vicente ◽  
Luiz Guillermo Coca Velarde ◽  
Gilson Teles Boaventura
Keyword(s):  
Thyroid Hormones ◽  
High Fat Diet ◽  
Female Offspring ◽  
Flaxseed Oil ◽  
Diabetic Rats ◽  
High Fat ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Flaxseed Flour ◽  
Maternal Consumption

Abstract. Objective: This study aimed to evaluate the effect of maternal consumption of flaxseed flour and oil on serum concentrations of glucose, insulin, and thyroid hormones of the adult female offspring of diabetic rats. Methods: Wistar rats were induced to diabetes by a high-fat diet (60%) and streptozotocin (35 mg/kg). Rats were mated and once pregnancy was confirmed, were divided into the following groups: Control Group (CG): casein-based diet; High-fat Group (HG): high-fat diet (49%); High-fat Flaxseed Group (HFG): high-fat diet supplemented with 25% flaxseed flour; High-fat Flaxseed Oil group (HOG): high-fat diet, where soya oil was replaced with flaxseed oil. After weaning, female pups (n = 6) from each group were separated, received a commercial rat diet and were sacrificed after 180 days. Serum insulin concentrations were determined by ELISA, the levels of triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) were determined by chemiluminescence. Results: There was a significant reduction in body weight at weaning in HG (−31%), HFG (−33%) and HOG (44%) compared to CG (p = 0.002), which became similar by the end of 180 days. Blood glucose levels were reduced in HFG (−10%, p = 0.044) when compared to CG, and there was no significant difference between groups in relation to insulin, T3, T4, and TSH after 180 days. Conclusions: Maternal severe hyperglycemia during pregnancy and lactation resulted in a microsomal offspring. Maternal consumption of flaxseed reduces blood glucose levels in adult offspring without significant effects on insulin levels and thyroid hormones.

Effects of Maternal Hyperglycemia Associated with Snack Intake on Male and Female Offspring High-Fat Diet Preference on Infancy

Metabolism ◽  
2021 ◽  
Vol 116 ◽  
pp. 154635
Author(s):  
Gustavo Venâncio da Silva ◽  
Marina Galleazzo Martins ◽  
Giovana Pereira de Oliveira ◽  
Alessandra Gonçalves Cruz ◽  
Larissa Pereira Rodrigues ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Female Offspring ◽  
High Fat ◽  
Male And Female ◽  
Maternal Hyperglycemia ◽  
Diet Preference
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