scholarly journals Chronic high-dosage fish oil exacerbates gut–liver axis injury in alcoholic steatohepatitis in mice: the roles of endotoxin and IL-4 in Kupffer cell polarization imbalance

2017 ◽  
Vol 6 (5) ◽  
pp. 611-620
Author(s):  
Xiao-Jun Li ◽  
Yun-Mei Mu ◽  
Qiu-Fang Qin ◽  
Zi-Xuan Zeng ◽  
Yu-Sang Li ◽  
...  
Keyword(s):  
Fish Oil ◽  
Kupffer Cell ◽  
Cell Polarization ◽  
Interleukin 4 ◽  
Alcoholic Steatohepatitis ◽  
Endotoxin Translocation ◽  
High Fish

Chronic high fish oil exacerbated ALD via endotoxin translocation and interleukin-4 suppression, followed by Kupffer cell polarization imbalance.

scholarly journals Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

Immunity ◽  
2020 ◽  
Vol 53 (3) ◽  
pp. 627-640.e5 ◽  
Author(s):  
Sophie Tran ◽  
Ines Baba ◽  
Lucie Poupel ◽  
Sébastien Dussaud ◽  
Martine Moreau ◽  
...  
Keyword(s):  
Kupffer Cell ◽  
Self Renewal ◽  
Alcoholic Steatohepatitis ◽  
Liver Response

scholarly journals Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice

Hepatology ◽  
2011 ◽  
Vol 54 (4) ◽  
pp. 1217-1226 ◽  
Author(s):  
Alexandre Louvet ◽  
Fatima Teixeira-Clerc ◽  
Marie-Noële Chobert ◽  
Vanessa Deveaux ◽  
Catherine Pavoine ◽  
...  
Keyword(s):  
Liver Disease ◽  
Kupffer Cell ◽  
Alcoholic Liver Disease ◽  
Cell Polarization ◽  
Cb2 Receptors ◽  
Cannabinoid Cb2 Receptors

scholarly journals A High-Fish Oil Diet Can Significantly Reshape The Gut Microbiota In Mice

2021 ◽  
Author(s):  
Han Sun ◽  
Dan Chen ◽  
Yingyun Yang ◽  
Bei Tan ◽  
Changzhi Huang ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Fish Oil ◽  
Microbial Diversity ◽  
Essential Role ◽  
Dextran Sulphate ◽  
Beneficial Effects ◽  
Proinflammatory Effect ◽  
Fish Oil Diet ◽  
High Fish ◽  
Microbiota Diversity

Abstract Background: Gut microbiota plays an essential role for human health and recent evidence has revealed the beneficial effects of fish oil supplements on the gut microbiota. The present study was to investigate the influence of fish oil on diet-based gut microbiota changes and colitis in mice and whether pyroptosis plays a role in this process.Results: A high-fish oil diet alleviated colitis, resulted in less weight loss and improved pathological scores. Caspase-1, activated in the dextran sulphate sodium (DSS) group, was suppressed by a high-fish oil diet. AIN-93M significantly decreased the gut microbial diversity of mice, increasing the abundances of Bacteroides and Parabacteroides and decreasing the abundance of Odoribacter. In contrast, gut microbial diversity was maintained in mice fed a high-fish oil diet; the Firmicutes: Bacteroidetes ratio was increased, the abundance of Parabacteroides was increased, and that the abundance of Odoribacter was decreased.Conclusion: AIN-93M can decrease gut microbiota diversity, which may be associated with a potential proinflammatory effect. Fish oil has anti-inflammatory effects. It can also restore and maintain microbial diversity and suppress pyroptosis activation.

Suppression of Altered Hepatic Foci Development by a High Fish Oil Diet Compared With a High Corn Oil Diet in Rats

2000 ◽  
Vol 38 (1) ◽  
pp. 50-59 ◽  
Author(s):  
Chong-Kuei Lii ◽  
Chu-Chyn Ou ◽  
Kai-Li Liu ◽  
Jer-Yuh Liu ◽  
Wea-Lung Lin ◽  
...  
Keyword(s):  
Fish Oil ◽  
Corn Oil ◽  
Altered Hepatic Foci ◽  
Fish Oil Diet ◽  
High Fish

High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice

2012 ◽  
Vol 302 (9) ◽  
pp. E1097-E1112 ◽  
Author(s):  
Qin Hao ◽  
Haldis H. Lillefosse ◽  
Even Fjære ◽  
Lene Secher Myrmel ◽  
Lisa K. Midtbø ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Secretion ◽  
Fish Oil ◽  
Glycemic Index ◽  
Metabolic Effects ◽  
Promoting Effect ◽  
Diet Induced Obesity ◽  
Fat Diets ◽  
Fish Oil Diet ◽  
High Fish

Fish oil rich in n-3 polyunsaturated fatty acids is known to attenuate diet-induced obesity and adipose tissue inflammation in rodents. Here we aimed to investigate whether different carbohydrate sources modulated the antiobesity effects of fish oil. By feeding C57BL/6J mice isocaloric high-fat diets enriched with fish oil for 6 wk, we show that increasing amounts of sucrose in the diets dose-dependently increased energy efficiency and white adipose tissue (WAT) mass. Mice receiving fructose had about 50% less WAT mass than mice fed a high fish oil diet supplemented with either glucose or sucrose, indicating that the glucose moiety of sucrose was responsible for the obesity-promoting effect of sucrose. To investigate whether the obesogenic effect of sucrose and glucose was related to stimulation of insulin secretion, we combined fish oil with high and low glycemic index (GI) starches. Mice receiving the fish oil diet containing the low-GI starch had significantly less WAT than mice fed high-GI starch. Moreover, inhibition of insulin secretion by administration of nifedipine significantly reduced WAT mass in mice fed a high-fish oil diet in combination with sucrose. Our data show that the macronutrient composition of the diet modulates the effects of fish oil. Fish oil combined with sucrose, glucose, or high-GI starch promotes obesity, and the reported anti-inflammatory actions of fish oil are abrogated. In conclusion, our data indicate that glycemic control of insulin secretion modulates metabolic effects of fish oil by demonstrating that high-GI carbohydrates attenuate the antiobesity effects of fish oil.

Lactobacillus paracasei Induces M2-Dominant Kupffer Cell Polarization in a Mouse Model of Nonalcoholic Steatohepatitis

2015 ◽  
Vol 60 (11) ◽  
pp. 3340-3350 ◽  
Author(s):  
Won Sohn ◽  
Dae Won Jun ◽  
Kang Nyeong Lee ◽  
Hang Lak Lee ◽  
Oh Young Lee ◽  
...  
Keyword(s):  
Mouse Model ◽  
Kupffer Cell ◽  
Nonalcoholic Steatohepatitis ◽  
Cell Polarization ◽  
Lactobacillus Paracasei
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